#Table S26. Mantle-specific or highly expressed genes. GeneID Known shell related protein IPR annotation Swissprot annotation GO terms Mantle expression Mantle/other Mantle Mantle edge Mantle pallial Digestive gland Female Gonad Gill Adductor muscle Hemolymph Labial palp CGI_10002880 Specific ° 7.8 2.2 13.4 0.0 0.0 0.0 0.0 0.0 0.0 CGI_10010022 Specific ° 9.5 7.2 11.8 0.0 0.0 0.0 0.0 0.0 0.0 CGI_10028555 Specific ° 10.9 11.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 CGI_10020144 Specific 555.43 6.5 4.6 8.3 0.1 0.0 0.0 0.0 0.0 0.0 CGI_10001497 "IPR008197: Whey acidic protein, 4-disulphide core" GO:0005576: extracellular region: Cellular Component; O:0030414: peptidase inhibitor activity: Molecular Function Specific 511.35 41.8 3.0 80.5 0.1 0.0 0.0 0.4 0.0 0.0 CGI_10001605 Specific 417.85 61.3 38.0 84.6 0.4 0.0 0.0 0.2 0.2 0.1 CGI_10022510 IPR002126: Cadherin; PR015919: Cadherin-like PCD23_HUMAN Protocadherin-23 OS=Homo sapiens GN=DCHS2 PE=2 SV=1 GO:0005509: calcium ion binding: Molecular Function; O:0007156: homophilic cell adhesion: Biological Process; O:0016020: membrane: Cellular Component Specific 378.90 6.3 2.8 9.8 0.1 0.0 0.0 0.0 0.0 0.0 CGI_10007833 "IPR004302: Chitin-binding, domain 3" GO:0019028: viral capsid: Cellular Component Specific 246.86 5.8 5.3 6.2 0.1 0.0 0.1 0.0 0.0 0.0 CGI_10007002 "IPR002223: Proteinase inhibitor I2, Kunitz metazoa; PR008197: Whey acidic protein, 4-disulphide core" TFPI1_RABIT Tissue factor pathway inhibitor OS=Oryctolagus cuniculus GN=TFPI PE=2 SV=2 GO:0004867: serine-type endopeptidase inhibitor activity: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0030414: peptidase inhibitor activity: Molecular Function Specific 205.63 19.5 12.4 26.6 0.4 0.0 0.1 0.0 0.0 0.0 CGI_10018987 Specific 173.44 149.7 70.7 228.8 3.0 0.0 0.2 1.8 0.0 0.3 CGI_10001496 Specific 169.46 10.5 3.3 17.6 0.2 0.0 0.0 0.2 0.0 0.0 CGI_10017380 Specific 166.62 17.5 15.4 19.6 0.6 0.0 0.0 0.0 0.0 0.0 CGI_10011110 "IPR001179: Peptidyl-prolyl cis-trans isomerase, FKBP-type" FKB1B_RABIT Peptidyl-prolyl cis-trans isomerase FKBP1B OS=Oryctolagus cuniculus GN=FKBP1B PE=3 SV=3 GO:0006457: protein folding: Biological Process Specific 163.77 37.4 24.3 50.5 0.9 0.4 0.0 0.0 0.0 0.0 CGI_10020950 Specific 148.98 70.8 19.3 122.3 0.0 0.6 0.7 1.0 0.0 0.6 CGI_10025222 Specific 140.41 82.4 58.2 106.6 3.3 0.0 0.0 0.2 0.0 0.0 CGI_10023338 "IPR003654: Paired-like homeodomain protein, OAR" GO:0003677: DNA binding: Molecular Function; O:0005634: nucleus: Cellular Component; O:0007275: multicellular organismal development: Biological Process Specific 138.26 18.9 10.9 26.9 0.4 0.3 0.0 0.1 0.0 0.0 CGI_10028037 Specific 137.07 194.4 132.1 256.7 6.5 0.8 0.0 1.2 0.0 0.0 CGI_10023200 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR019791: Haem peroxidase, animal, subgroup" PERC_DROME Chorion peroxidase OS=Drosophila melanogaster GN=pxt PE=2 SV=3 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process Specific 132.63 19.9 8.2 31.6 0.6 0.1 0.0 0.3 0.0 0.0 CGI_10017273 "IPR002350: Proteinase inhibitor I1, Kazal" AGRIN_HUMAN Agrin OS=Homo sapiens GN=AGRN PE=1 SV=4 GO:0005515: protein binding: Molecular Function Specific 132.10 71.3 41.5 101.2 1.5 0.0 1.0 0.8 0.0 0.0 CGI_10021075 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function Specific 130.66 78.0 50.0 105.9 2.9 0.3 0.0 0.4 0.0 0.0 CGI_10020876 Specific 130.34 49.1 28.2 70.0 1.3 0.9 0.0 0.0 0.0 0.0 CGI_10026565 "IPR000047: Helix-turn-helix motif, lambda-like repressor; PR001356: Homeobox; PR009057: Homeodomain-like; PR017995: Homeobox protein, antennapedia type; PR020479: Homeobox, eukaryotic" HXB7_BOVIN Homeobox protein Hox-B7 OS=Bos taurus GN=HOXB7 PE=2 SV=1 "GO:0003677: DNA binding: Molecular Function; O:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005634: nucleus: Cellular Component; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" Specific 130.33 64.3 39.4 89.2 0.5 0.2 0.8 1.1 0.0 0.3 CGI_10025983 Specific 128.41 17.3 9.3 25.3 0.5 0.4 0.0 0.0 0.0 0.0 CGI_10008376 IMSP-4_Crassostrea_gigas_HS245553[EST] Specific 127.90 167.6 84.6 250.5 6.4 0.3 0.1 1.1 0.0 0.0 CGI_10015798 IPR008160: Collagen triple helix repeat CO6A3_CHICK Collagen alpha-3(VI) chain OS=Gallus gallus GN=COL6A3 PE=2 SV=2 Specific 127.71 8.9 9.8 8.1 0.4 0.0 0.0 0.0 0.0 0.0 CGI_10018960 "IPR008197: Whey acidic protein, 4-disulphide core" GO:0005576: extracellular region: Cellular Component; O:0030414: peptidase inhibitor activity: Molecular Function Specific 120.60 7.0 5.2 8.9 0.2 0.0 0.0 0.2 0.0 0.0 CGI_10011913 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function Specific 117.94 178.3 135.3 221.3 7.8 0.1 0.1 1.1 0.0 0.0 CGI_10028285 "IPR006150: Cysteine-rich repeat; PR008037: Proteinase inhibitor I19, pacifastin; PR020862: Pacifastin, arthropoda" GO:0030414: peptidase inhibitor activity: Molecular Function Specific 117.70 137.7 113.9 161.6 5.8 0.2 0.1 0.9 0.0 0.0 CGI_10011915 Specific 117.63 111.9 96.0 127.9 5.1 0.0 0.0 0.6 0.0 0.0 CGI_10000667 Specific 114.43 19.8 14.4 25.2 0.9 0.0 0.2 0.0 0.0 0.0 CGI_10026466 IPR001612: Caveolin CAV1_DASNO Caveolin-1 OS=Dasypus novemcinctus GN=CAV1 PE=3 SV=1 Specific 114.10 11.2 11.0 11.4 0.6 0.0 0.0 0.0 0.0 0.0 CGI_10016430 Specific 113.63 65.9 51.0 80.9 3.2 0.0 0.0 0.3 0.0 0.0 CGI_10024867 "IPR001223: Glycoside hydrolase, family 18, catalytic domain; PR002172: LDLR class A repeat; PR011583: Chitinase II; PR017853: Glycoside hydrolase, catalytic core" CHIT1_HUMAN Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 "GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds: Molecular Function; O:0004568: chitinase activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005975: carbohydrate metabolic process: Biological Process; O:0006032: chitin catabolic process: Biological Process" Specific 113.13 5.8 4.3 7.4 0.1 0.1 0.1 0.0 0.0 0.0 CGI_10022167 Specific 112.08 14.0 10.4 17.6 0.4 0.3 0.1 0.0 0.0 0.0 CGI_10011244 Specific 104.00 58.4 49.2 67.7 1.8 0.3 1.0 0.4 0.0 0.0 CGI_10013316 Specific 101.95 37.9 23.0 52.8 1.7 0.0 0.0 0.5 0.0 0.0 CGI_10013165 Specific 101.65 5.8 8.6 3.0 0.3 0.0 0.0 0.0 0.0 0.0 CGI_10007939 "IPR013111: EGF, extracellular" Specific 101.56 10.5 7.0 14.0 0.5 0.0 0.1 0.0 0.0 0.0 CGI_10008833 Specific 101.22 120.6 85.0 156.3 5.1 0.0 0.2 1.4 0.4 0.1 CGI_10025039 "IPR001846: von Willebrand factor, type D domain" Specific 100.15 12.2 9.0 15.4 0.6 0.0 0.1 0.0 0.0 0.0 CGI_10003785 Specific 97.04 55.5 36.3 74.7 3.0 0.1 0.0 0.3 0.0 0.1 CGI_10000943 Specific 96.65 74.9 62.5 87.3 2.7 0.3 1.1 0.5 0.0 0.0 CGI_10007556 Specific 95.47 571.6 425.5 717.7 30.8 0.6 0.3 4.3 0.0 0.0 CGI_10005095 "IPR002223: Proteinase inhibitor I2, Kunitz metazoa; PR008037: Proteinase inhibitor I19, pacifastin" TKDP1_SHEEP Trophoblast Kunitz domain protein 1 OS=Ovis aries GN=TKDP1 PE=2 SV=1 GO:0004867: serine-type endopeptidase inhibitor activity: Molecular Function; O:0030414: peptidase inhibitor activity: Molecular Function Specific 94.50 12.9 8.1 17.7 0.5 0.4 0.0 0.0 0.0 0.0 CGI_10021307 IPR000863: Sulfotransferase domain CHST5_MOUSE Carbohydrate sulfotransferase 5 OS=Mus musculus GN=Chst5 PE=2 SV=1 GO:0008146: sulfotransferase activity: Molecular Function Specific 94.24 5.3 5.4 5.3 0.1 0.0 0.1 0.1 0.0 0.2 CGI_10011015 "IPR001820: Proteinase inhibitor I35, tissue inhibitor of metalloproteinase; PR008993: Tissue inhibitor of metalloproteinases-like, OB-fold" TIMP3_SCYTO Metalloproteinase inhibitor 3 OS=Scyliorhinus torazame GN=TIMP3 PE=2 SV=1 GO:0005578: proteinaceous extracellular matrix: Cellular Component; O:0008191: metalloendopeptidase inhibitor activity: Molecular Function Specific 90.91 37.6 29.2 46.0 1.3 0.0 0.5 0.2 0.4 0.0 CGI_10009507 "IPR001179: Peptidyl-prolyl cis-trans isomerase, FKBP-type; PR002048: Calcium-binding EF-hand; PR018249: EF-HAND 2" FKB14_MOUSE FK506-binding protein 14 OS=Mus musculus GN=Fkbp14 PE=2 SV=1 GO:0005509: calcium ion binding: Molecular Function; O:0006457: protein folding: Biological Process Specific 90.61 11.9 8.1 15.7 0.8 0.0 0.0 0.0 0.0 0.0 CGI_10015841 Specific 90.12 157.9 125.4 190.4 8.6 0.3 0.0 1.4 0.0 0.2 CGI_10009633 Specific 88.46 238.9 202.2 275.5 12.6 0.5 0.3 2.1 0.3 0.5 CGI_10018772 Specific 88.16 173.8 88.4 259.3 9.9 0.1 0.1 1.7 0.0 0.0 CGI_10017437 Specific 87.82 117.2 89.8 144.7 7.1 0.0 0.0 0.9 0.0 0.0 CGI_10007857 "IPR001540: Glycoside hydrolase, family 20; PR008965: Carbohydrate-binding; PR015883: Glycoside hydrolase, family 20, catalytic core; PR017853: Glycoside hydrolase, catalytic core" CHB_SERMA Chitobiase OS=Serratia marcescens GN=chb PE=1 SV=1 "GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds: Molecular Function; O:0004563: beta-N-acetylhexosaminidase activity: Molecular Function; O:0005975: carbohydrate metabolic process: Biological Process; O:0030246: carbohydrate binding: Molecular Function" Specific 86.79 94.0 51.2 136.8 4.8 0.5 0.1 1.0 0.0 0.0 CGI_10025307 Specific 84.89 278.5 218.6 338.4 8.9 0.9 6.3 3.0 0.2 0.3 CGI_10025226 Specific 84.39 41.8 27.2 56.3 2.2 0.6 0.0 0.1 0.0 0.0 CGI_10012612 Specific 84.35 40.9 22.9 58.9 2.4 0.4 0.0 0.2 0.0 0.0 CGI_10024445 Specific 84.16 54.3 43.2 65.3 3.9 0.0 0.0 0.0 0.0 0.0 CGI_10023959 IPR019019: H-type lectin domain GO:0005529: sugar binding: Molecular Function; O:0007155: cell adhesion: Biological Process Specific 84.15 489.5 561.1 417.9 23.1 0.0 8.5 3.3 0.0 0.0 CGI_10026598 IPR002557: Chitin binding domain CPG2_CAEEL Chondroitin proteoglycan-2 OS=Caenorhabditis elegans GN=cpg-2 PE=1 SV=3 GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 83.83 10.1 9.6 10.5 0.5 0.0 0.1 0.1 0.0 0.0 CGI_10005424 IMSP-6_Crassostrea_gigas_CU992451[EST] IPR001466: Beta-lactamase-related; PR012338: Beta-lactamase-type transpeptidase fold FMTA_STAAC Protein fmtA OS=Staphylococcus aureus (strain COL) GN=fmtA PE=2 SV=1 Specific 83.55 348.1 195.5 500.8 17.3 0.4 4.5 2.4 0.3 0.0 CGI_10028414 "IPR001007: von Willebrand factor, type C; PR006552: VWC out; PR008037: Proteinase inhibitor I19, pacifastin" KCP_XENLA Kielin/chordin-like protein OS=Xenopus laevis GN=kcp PE=2 SV=1 GO:0005515: protein binding: Molecular Function; O:0030414: peptidase inhibitor activity: Molecular Function Specific 83.52 27.8 20.0 35.6 0.8 0.0 0.5 0.2 0.5 0.1 CGI_10018365 IPR002909: Cell surface receptor IPT/TIG; PR014756: Immunoglobulin E-set PKHL1_HUMAN Fibrocystin-L OS=Homo sapiens GN=PKHD1L1 PE=2 SV=1 GO:0005515: protein binding: Molecular Function Specific 81.68 41.7 19.0 64.3 1.2 1.2 0.1 0.4 0.1 0.0 CGI_10022840 Specific 81.10 16.2 11.8 20.7 0.9 0.2 0.0 0.2 0.0 0.0 CGI_10007793 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function Specific 79.67 20.3 6.1 34.6 0.7 0.2 0.0 0.4 0.0 0.1 CGI_10016278 Specific 79.59 967.1 896.6 1037.6 64.7 0.6 0.4 7.2 0.0 0.0 CGI_10001807 IPR006210: Epidermal growth factor-like MEG11_HUMAN Multiple epidermal growth factor-like domains 11 OS=Homo sapiens GN=MEGF11 PE=2 SV=3 GO:0005515: protein binding: Molecular Function Specific 79.17 7.8 6.4 9.2 0.3 0.0 0.0 0.0 0.1 0.2 CGI_10009634 Specific 78.92 434.3 401.2 467.5 29.4 0.1 0.2 3.3 0.0 0.0 CGI_10013058 "IPR001356: Homeobox; PR009057: Homeodomain-like; PR020479: Homeobox, eukaryotic" EVX1_MOUSE Homeobox even-skipped homolog protein 1 OS=Mus musculus GN=Evx1 PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" Specific 78.60 13.8 8.2 19.4 1.1 0.0 0.0 0.0 0.0 0.0 CGI_10007530 TEMPT_APLCA Temptin OS=Aplysia californica PE=1 SV=1 Specific 78.20 69.6 56.0 83.2 3.6 0.0 0.8 0.8 0.2 0.0 CGI_10017379 Specific 78.00 8.7 7.3 10.1 0.7 0.0 0.0 0.0 0.0 0.0 CGI_10000153 Specific 76.89 54.6 47.5 61.6 4.0 0.0 0.0 0.2 0.0 0.0 CGI_10016723 Specific 76.76 25.3 20.8 29.8 1.3 0.2 0.3 0.3 0.0 0.0 CGI_10011916 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function Specific 76.66 218.5 175.6 261.4 12.9 0.9 2.0 1.2 0.0 0.0 CGI_10007832 IPR001356: Homeobox; PR009057: Homeodomain-like GSC_DROME Homeobox protein goosecoid OS=Drosophila melanogaster GN=Gsc PE=1 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" Specific 76.49 18.7 9.0 28.5 0.9 0.3 0.0 0.3 0.0 0.0 CGI_10005482 Specific 76.00 16.7 13.1 20.4 0.6 0.4 0.2 0.2 0.0 0.0 CGI_10014343 Specific 75.70 11.4 6.7 16.0 0.3 0.0 0.0 0.0 0.6 0.0 CGI_10016014 Specific 75.36 19.7 16.2 23.3 1.1 0.2 0.0 0.4 0.0 0.0 CGI_10004863 IPR014044: CAP domain MR30_CONMR Cysteine-rich secretory protein Mr30 OS=Conus marmoreus PE=1 SV=1 Specific 74.95 77.6 50.1 105.1 5.5 0.2 0.1 0.5 0.0 0.0 CGI_10004865 IPR001283: Allergen V5/Tpx-1-related; PR002413: Ves allergen; PR014044: CAP domain TX31_CONTE Substrate-specific endoprotease Tex31 OS=Conus textile GN=TEX31 PE=1 SV=1 GO:0005576: extracellular region: Cellular Component Specific 74.88 79.7 56.4 103.1 5.0 0.2 0.7 0.4 0.1 0.0 CGI_10007753 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function Specific 74.85 132.4 88.1 176.6 7.6 1.5 0.4 0.9 0.3 0.0 CGI_10026226 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function Specific 74.82 197.0 122.8 271.2 13.4 1.1 0.0 1.3 0.1 0.0 CGI_10012351 IPR000001: Kringle; PR003598: Immunoglobulin subtype 2; PR003599: Immunoglobulin subtype; PR007110: Immunoglobulin-like; PR013098: Immunoglobulin I-set; PR013806: Kringle-like fold PLMN_BOVIN Plasminogen OS=Bos taurus GN=PLG PE=1 SV=2 GO:0005515: protein binding: Molecular Function Specific 74.47 6.3 4.4 8.2 0.2 0.1 0.2 0.1 0.0 0.0 CGI_10007834 Specific 74.27 5.1 3.2 7.0 0.3 0.1 0.0 0.1 0.0 0.0 CGI_10018865 Specific 74.26 32.6 23.6 41.6 1.9 0.1 0.2 0.2 0.1 0.1 CGI_10010209 Specific 73.84 14.0 15.5 12.6 0.9 0.3 0.0 0.0 0.0 0.0 CGI_10006287 Specific 73.49 13.1 10.2 16.1 0.0 0.4 0.3 0.3 0.0 0.0 CGI_10003786 Specific 73.37 142.5 104.2 180.7 10.1 0.0 0.0 1.3 0.0 0.2 CGI_10025006 IPR001283: Allergen V5/Tpx-1-related; PR003582: Metridin-like ShK toxin; PR014044: CAP domain CRLD2_MOUSE Cysteine-rich secretory protein LCCL domain-containing 2 OS=Mus musculus GN=Crispld2 PE=1 SV=1 GO:0005576: extracellular region: Cellular Component Specific 73.28 12.6 3.3 21.8 1.0 0.0 0.0 0.0 0.0 0.0 CGI_10010239 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR019791: Haem peroxidase, animal, subgroup" PERC_DROME Chorion peroxidase OS=Drosophila melanogaster GN=pxt PE=2 SV=3 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process Specific 72.16 9.0 5.2 12.9 0.1 0.4 0.0 0.1 0.1 0.0 CGI_10024591 Specific 72.13 374.2 319.4 429.1 22.9 0.4 4.7 3.0 0.1 0.1 CGI_10025598 Specific 71.60 31.3 12.9 49.6 2.2 0.0 0.0 0.4 0.0 0.0 CGI_10025712 Specific 71.19 8.0 4.2 11.7 0.5 0.2 0.0 0.1 0.0 0.0 CGI_10014831 "IPR004841: Amino acid permease domain; PR015882: Acetylhexosaminidase, subunit a/b; PR015883: Glycoside hydrolase, family 20, catalytic core; PR017853: Glycoside hydrolase, catalytic core" S12A2_SQUAC Solute carrier family 12 member 2 OS=Squalus acanthias GN=SLC12A2 PE=1 SV=1 "GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds: Molecular Function; O:0004563: beta-N-acetylhexosaminidase activity: Molecular Function; O:0005975: carbohydrate metabolic process: Biological Process; O:0006810: transport: Biological Process; O:0016020: membrane: Cellular Component; O:0055085: transmembrane transport: Biological Process" Specific 70.74 49.2 39.6 58.7 1.8 0.1 0.5 0.4 0.3 1.1 CGI_10012348 IPR002557: Chitin binding domain; PR003598: Immunoglobulin subtype 2; PR003599: Immunoglobulin subtype; PR007110: Immunoglobulin-like; PR008985: Concanavalin A-like lectin/glucanase; PR013098: Immunoglobulin I-set; PR013151: Immunoglobulin HMCN1_HUMAN Hemicentin-1 OS=Homo sapiens GN=HMCN1 PE=1 SV=2 GO:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 70.51 80.3 50.4 110.1 3.7 0.4 1.4 1.2 0.0 0.1 CGI_10005425 IMSP-6_Crassostrea_gigas_CU992451[EST] IPR001466: Beta-lactamase-related; PR012338: Beta-lactamase-type transpeptidase fold Specific 70.33 537.6 341.3 733.9 30.0 0.6 10.0 4.7 0.2 0.4 CGI_10016036 Specific 69.99 657.5 589.6 725.4 44.9 0.6 6.0 4.2 0.4 0.3 CGI_10001564 Specific 69.85 14.4 8.8 20.0 0.9 0.3 0.0 0.1 0.0 0.0 CGI_10003117 IPR001828: Extracellular ligand-binding receptor ANPRC_HUMAN Atrial natriuretic peptide clearance receptor OS=Homo sapiens GN=NPR3 PE=1 SV=2 Specific 69.50 138.3 125.8 150.8 6.8 0.0 3.8 1.2 0.0 0.2 CGI_10001748 Specific 69.45 118.5 71.3 165.8 9.0 0.1 0.1 1.0 0.1 0.0 CGI_10018233 Specific 69.35 38.3 29.6 47.0 2.6 0.3 0.0 0.4 0.0 0.0 CGI_10012353 IPR002557: Chitin binding domain GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 69.14 233.2 220.2 246.3 11.7 0.4 6.4 1.6 0.1 0.0 CGI_10000964 Specific 67.91 10.3 11.0 9.6 0.0 0.0 0.2 0.2 0.3 0.2 CGI_10003000 EP_protein_precursor_Mytilus_edulis_AAQ63463.1 IPR001073: Complement C1q protein; PR008983: Tumour necrosis factor-like C1QL2_HUMAN Complement C1q-like protein 2 OS=Homo sapiens GN=C1QL2 PE=2 SV=1 GO:0005515: protein binding: Molecular Function Specific 67.55 35.7 22.6 48.8 1.8 0.1 0.8 0.3 0.0 0.1 CGI_10010240 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR019791: Haem peroxidase, animal, subgroup" PERC_DROME Chorion peroxidase OS=Drosophila melanogaster GN=pxt PE=2 SV=3 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process Specific 67.27 102.1 72.5 131.8 4.6 0.5 3.0 0.6 0.1 0.2 CGI_10006145 PFMG1_Pinctada_fucata_AAZ76255.1 IPR018249: EF-HAND 2 Specific 67.22 90.0 66.0 113.9 3.3 0.0 3.2 0.6 0.1 0.9 CGI_10026599 "IPR001223: Glycoside hydrolase, family 18, catalytic domain; PR011583: Chitinase II; PR017853: Glycoside hydrolase, catalytic core" CHIA_RAT Acidic mammalian chitinase OS=Rattus norvegicus GN=Chia PE=2 SV=1 "GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds: Molecular Function; O:0004568: chitinase activity: Molecular Function; O:0005975: carbohydrate metabolic process: Biological Process; O:0006032: chitin catabolic process: Biological Process" Specific 66.49 34.5 25.0 43.9 1.7 0.1 1.0 0.2 0.1 0.0 CGI_10028286 "IPR006150: Cysteine-rich repeat; PR008037: Proteinase inhibitor I19, pacifastin" GO:0030414: peptidase inhibitor activity: Molecular Function Specific 66.49 163.7 109.7 217.7 10.1 0.2 2.3 2.0 0.2 0.0 CGI_10025225 Specific 66.42 7.1 4.0 10.2 0.0 0.6 0.0 0.0 0.0 0.0 CGI_10026733 Specific 65.62 13.9 13.2 14.6 0.7 0.5 0.0 0.0 0.1 0.0 CGI_10024590 Specific 65.11 11.0 9.4 12.5 0.6 0.0 0.2 0.2 0.0 0.1 CGI_10027183 IPR000082: SEA Specific 65.08 14.2 10.0 18.4 0.8 0.1 0.3 0.1 0.0 0.0 CGI_10018174 Specific 64.98 11.2 8.6 13.7 0.7 0.0 0.2 0.2 0.0 0.0 CGI_10012349 Specific 64.95 15.5 9.7 21.2 1.4 0.0 0.0 0.0 0.0 0.0 CGI_10021747 Specific 64.49 102.2 80.8 123.7 8.8 0.0 0.0 0.5 0.0 0.2 CGI_10022263 Specific 64.02 119.1 79.4 158.7 5.4 2.5 0.8 1.3 0.7 0.5 CGI_10020692 Specific 63.72 74.9 54.9 94.9 6.3 0.0 0.3 0.5 0.0 0.0 CGI_10005220 IPR001073: Complement C1q protein; PR008983: Tumour necrosis factor-like GO:0005515: protein binding: Molecular Function Specific 63.37 67.8 48.4 87.3 3.9 0.6 1.0 0.3 0.2 0.5 CGI_10013011 Specific 62.69 52.9 68.6 37.1 1.4 0.6 2.9 0.3 0.0 0.0 CGI_10013710 IPR008979: Galactose-binding domain-like TIE1_BOVIN Tyrosine-protein kinase receptor Tie-1 OS=Bos taurus GN=TIE1 PE=2 SV=1 Specific 62.63 27.0 26.7 27.3 1.9 0.0 0.5 0.1 0.1 0.0 CGI_10026843 Specific 62.57 94.0 61.9 126.0 7.9 0.3 0.0 0.8 0.0 0.0 CGI_10004228 Specific 62.20 127.1 85.5 168.8 7.2 0.1 3.3 1.4 0.0 0.2 CGI_10023836 Specific 62.12 9.2 1.6 16.9 0.3 0.4 0.0 0.2 0.0 0.0 CGI_10008434 Specific 61.82 90.3 57.5 123.1 6.8 0.1 1.1 0.8 0.0 0.0 CGI_10017544 IMSP-2_Crassostrea_gigas_AM868448[EST]_AM864770[EST] "IPR000742: Epidermal growth factor-like, type 3; PR001507: Endoglin/CD105 antigen; PR006210: Epidermal growth factor-like" WIF1_RAT Wnt inhibitory factor 1 OS=Rattus norvegicus GN=Wif1 PE=2 SV=1 GO:0005515: protein binding: Molecular Function Specific 61.78 99.8 85.3 114.3 5.6 0.0 3.0 1.0 0.1 0.1 CGI_10026605 "IPR001223: Glycoside hydrolase, family 18, catalytic domain; PR002557: Chitin binding domain; PR011583: Chitinase II; PR017853: Glycoside hydrolase, catalytic core" CHIT1_HUMAN Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 "GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds: Molecular Function; O:0004568: chitinase activity: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0005975: carbohydrate metabolic process: Biological Process; O:0006030: chitin metabolic process: Biological Process; O:0006032: chitin catabolic process: Biological Process; O:0008061: chitin binding: Molecular Function" Specific 61.42 120.2 88.5 151.8 6.6 0.4 3.7 0.8 0.1 0.2 CGI_10027091 Specific 60.79 20.1 13.3 26.8 1.5 0.2 0.1 0.1 0.0 0.0 CGI_10018265 IPR002126: Cadherin; PR015919: Cadherin-like PCD23_HUMAN Protocadherin-23 OS=Homo sapiens GN=DCHS2 PE=2 SV=1 GO:0005509: calcium ion binding: Molecular Function; O:0007156: homophilic cell adhesion: Biological Process; O:0016020: membrane: Cellular Component Specific 60.28 11.0 5.5 16.4 0.9 0.0 0.0 0.2 0.0 0.0 CGI_10020608 Specific 60.21 7.1 7.2 7.0 0.7 0.0 0.0 0.0 0.0 0.0 CGI_10016016 "IPR000436: Sushi/SCR/CCP; PR002035: von Willebrand factor, type A; PR002557: Chitin binding domain; PR008985: Concanavalin A-like lectin/glucanase; PR016060: Complement control module" "SVEP1_HUMAN Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens GN=SVEP1 PE=1 SV=2" GO:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 60.03 34.5 27.3 41.7 1.7 0.5 1.0 0.2 0.1 0.0 CGI_10000668 IPR001828: Extracellular ligand-binding receptor GCY3E_DROME Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 Specific 58.88 23.8 15.7 32.0 1.8 0.0 0.3 0.3 0.0 0.0 CGI_10015567 "IPR002223: Proteinase inhibitor I2, Kunitz metazoa" IP52_ANESU Kunitz-type proteinase inhibitor 5 II OS=Anemonia sulcata PE=1 SV=2 GO:0004867: serine-type endopeptidase inhibitor activity: Molecular Function Specific 58.71 19.3 14.6 24.0 1.0 0.0 0.2 0.0 0.7 0.0 CGI_10020611 Specific 58.50 56.5 45.5 67.5 2.6 0.0 2.4 0.8 0.0 0.0 CGI_10018867 Specific 58.01 48.9 31.0 66.8 3.3 0.2 0.0 0.5 1.0 0.0 CGI_10012352 IPR002557: Chitin binding domain; PR003598: Immunoglobulin subtype 2; PR003599: Immunoglobulin subtype; PR007110: Immunoglobulin-like; PR008985: Concanavalin A-like lectin/glucanase; PR013098: Immunoglobulin I-set FSTL4_HUMAN Follistatin-related protein 4 OS=Homo sapiens GN=FSTL4 PE=2 SV=2 GO:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 57.87 210.8 169.4 252.1 11.1 2.0 7.2 1.6 0.1 0.0 CGI_10009505 IPR002048: Calcium-binding EF-hand; PR018249: EF-HAND 2 FKBP9_BOVIN FK506-binding protein 9 OS=Bos taurus GN=FKBP9 PE=2 SV=1 GO:0005509: calcium ion binding: Molecular Function Specific 57.63 9.6 4.9 14.3 0.6 0.0 0.1 0.0 0.2 0.1 CGI_10005573 "IPR008197: Whey acidic protein, 4-disulphide core; PR015874: 4-disulphide core" GO:0005576: extracellular region: Cellular Component; O:0030414: peptidase inhibitor activity: Molecular Function Specific 57.54 160.3 129.6 191.1 10.9 0.4 2.1 2.4 0.9 0.0 CGI_10014774 IPR000033: LDLR class B repeat; PR000436: Sushi/SCR/CCP; PR006210: Epidermal growth factor-like; PR016060: Complement control module LRP1B_HUMAN Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens GN=LRP1B PE=1 SV=2 GO:0005515: protein binding: Molecular Function; O:0016020: membrane: Cellular Component Specific 57.43 16.8 12.0 21.7 1.1 0.0 0.0 0.1 0.0 0.6 CGI_10004227 Specific 57.30 205.4 152.8 258.0 13.1 0.2 6.0 2.2 0.1 0.0 CGI_10018866 Specific 57.21 5.5 5.2 5.9 0.3 0.2 0.0 0.0 0.1 0.0 CGI_10020609 Specific 57.16 47.2 30.8 63.5 2.9 0.0 1.0 1.0 0.0 0.0 CGI_10000389 "IPR001134: Netrin domain; PR001820: Proteinase inhibitor I35, tissue inhibitor of metalloproteinase; PR008993: Tissue inhibitor of metalloproteinases-like, OB-fold" TIMP3_CHICK Metalloproteinase inhibitor 3 OS=Gallus gallus GN=TIMP3 PE=1 SV=2 GO:0005515: protein binding: Molecular Function; O:0005578: proteinaceous extracellular matrix: Cellular Component; O:0008191: metalloendopeptidase inhibitor activity: Molecular Function Specific 56.23 214.1 187.9 240.2 7.3 10.3 3.5 1.8 0.0 0.0 CGI_10008711 "IPR008972: Cupredoxin; PR011706: Multicopper oxidase, type 2" LAC15_ARATH Laccase-15 OS=Arabidopsis thaliana GN=TT10 PE=1 SV=1 GO:0005507: copper ion binding: Molecular Function; O:0016491: oxidoreductase activity: Molecular Function; O:0055114: oxidation-reduction process: Biological Process Specific 56.02 31.7 27.1 36.2 3.3 0.0 0.0 0.1 0.0 0.0 CGI_10010037 Specific 55.91 32.2 31.6 32.9 1.7 0.8 0.0 0.6 0.4 0.0 CGI_10018173 Specific 55.77 33.6 26.2 40.9 2.7 0.2 0.4 0.4 0.0 0.0 CGI_10004704 "IPR008197: Whey acidic protein, 4-disulphide core" IF2_CLOCE Translation initiation factor IF-2 OS=Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) GN=infB PE=3 SV=1 GO:0005576: extracellular region: Cellular Component; O:0030414: peptidase inhibitor activity: Molecular Function Specific 55.69 15.1 8.4 21.9 1.3 0.0 0.2 0.1 0.0 0.1 CGI_10019606 "IPR002350: Proteinase inhibitor I1, Kazal; PR011497: Protease inhibitor, Kazal-type" MCPI_MELCP Four-domain proteases inhibitor OS=Melithaea caledonica PE=1 SV=1 GO:0005515: protein binding: Molecular Function Specific 55.50 12.6 10.2 15.0 1.0 0.0 0.0 0.2 0.0 0.1 CGI_10011732 Specific 55.47 219.2 171.6 266.8 8.5 1.2 6.8 1.5 0.2 5.6 CGI_10028014 Pif177 "IPR002035: von Willebrand factor, type A; PR002557: Chitin binding domain" GO:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 55.30 194.7 155.6 233.8 12.8 0.5 6.3 1.5 0.0 0.1 CGI_10017086 Specific 55.30 37.9 24.0 51.8 2.6 0.0 1.2 0.3 0.0 0.0 CGI_10003362 "IPR002350: Proteinase inhibitor I1, Kazal; PR011497: Protease inhibitor, Kazal-type" GO:0005515: protein binding: Molecular Function Specific 55.10 14.3 12.9 15.7 0.8 0.2 0.5 0.1 0.0 0.0 CGI_10016999 "IPR001590: Peptidase M12B, ADAM/reprolysin" ATS16_MOUSE A disintegrin and metalloproteinase with thrombospondin motifs 16 OS=Mus musculus GN=Adamts16 PE=2 SV=2 GO:0004222: metalloendopeptidase activity: Molecular Function; O:0006508: proteolysis: Biological Process Specific 55.00 79.8 66.6 93.1 5.1 0.3 2.5 0.7 0.1 0.1 CGI_10016015 "IPR001590: Peptidase M12B, ADAM/reprolysin" ATS18_MOUSE A disintegrin and metalloproteinase with thrombospondin motifs 18 OS=Mus musculus GN=Adamts18 PE=2 SV=1 GO:0004222: metalloendopeptidase activity: Molecular Function; O:0006508: proteolysis: Biological Process Specific 54.74 20.8 15.9 25.7 2.0 0.1 0.1 0.1 0.0 0.0 CGI_10018541 "IPR000203: GPS domain; PR000832: GPCR, family 2, secretin-like; PR001304: C-type lectin; PR016187: C-type lectin fold; PR017981: GPCR, family 2-like" GP112_HUMAN Probable G-protein coupled receptor 112 OS=Homo sapiens GN=GPR112 PE=2 SV=2 GO:0004888: transmembrane receptor activity: Molecular Function; O:0004930: G-protein coupled receptor activity: Molecular Function; O:0005488: binding: Molecular Function; O:0007166: cell surface receptor linked signaling pathway: Biological Process; O:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0007218: neuropeptide signaling pathway: Biological Process; O:0016020: membrane: Cellular Component Specific 54.59 35.2 27.0 43.5 2.3 0.1 1.1 0.3 0.1 0.0 CGI_10023446 Specific 54.51 473.5 354.6 592.4 38.1 0.3 8.8 4.1 0.0 0.8 CGI_10017398 Specific 54.40 100.5 77.6 123.3 8.7 0.3 1.3 0.6 0.3 0.0 CGI_10017543 IMSP-2_Crassostrea_gigas_AM868448[EST]_AM864770[EST] "IPR000742: Epidermal growth factor-like, type 3; PR001507: Endoglin/CD105 antigen; PR006210: Epidermal growth factor-like" WIF1_RAT Wnt inhibitory factor 1 OS=Rattus norvegicus GN=Wif1 PE=2 SV=1 GO:0005515: protein binding: Molecular Function Specific 54.10 120.1 101.6 138.6 6.9 0.4 3.6 0.9 1.4 0.0 CGI_10022481 IPR014044: CAP domain PI16_MOUSE Peptidase inhibitor 16 OS=Mus musculus GN=Pi16 PE=2 SV=1 Specific 53.41 50.2 27.2 73.3 2.6 0.9 0.0 1.1 0.9 0.2 CGI_10003449 TEMPT_APLCA Temptin OS=Aplysia californica PE=1 SV=1 Specific 53.12 15.1 11.9 18.2 0.9 0.2 0.5 0.1 0.0 0.0 CGI_10006457 Specific 53.10 58.9 56.1 61.6 4.4 1.5 0.3 0.5 0.0 0.0 CGI_10005096 "IPR008197: Whey acidic protein, 4-disulphide core" GO:0005576: extracellular region: Cellular Component; O:0030414: peptidase inhibitor activity: Molecular Function Specific 52.72 88.4 62.9 113.9 6.6 0.3 2.3 0.6 0.2 0.0 CGI_10011540 Specific 52.35 24.5 10.9 38.1 2.8 0.0 0.0 0.0 0.0 0.0 CGI_10016778 Specific 51.72 101.9 76.3 127.4 9.4 0.0 0.4 1.5 0.0 0.6 CGI_10012419 Specific 51.55 128.4 105.2 151.5 5.2 1.3 5.2 1.1 0.2 1.9 CGI_10021746 Specific 51.33 42.6 32.5 52.7 4.3 0.0 0.0 0.5 0.0 0.2 CGI_10006160 Specific 51.31 148.5 111.0 186.0 13.9 1.9 0.2 1.4 0.0 0.0 CGI_10014320 Specific 51.17 354.4 256.7 452.2 21.3 1.2 6.5 5.7 6.7 0.1 CGI_10019232 TEMPT_APLCA Temptin OS=Aplysia californica PE=1 SV=1 Specific 50.68 61.0 52.0 70.0 2.9 0.3 1.2 0.7 0.3 1.8 CGI_10005773 Specific 50.58 63.8 50.7 77.0 4.2 0.0 2.1 0.9 0.0 0.4 CGI_10027473 "IPR011330: Glycoside hydrolase/deacetylase, beta/alpha-barrel" GO:0003824: catalytic activity: Molecular Function; O:0005975: carbohydrate metabolic process: Biological Process Specific 50.46 171.4 129.1 213.7 10.6 0.5 7.6 1.6 0.0 0.1 CGI_10023084 IPR002557: Chitin binding domain GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 49.96 84.5 60.6 108.4 5.0 0.8 2.8 0.6 0.1 0.9 CGI_10016923 "IPR008197: Whey acidic protein, 4-disulphide core" GO:0005576: extracellular region: Cellular Component; O:0030414: peptidase inhibitor activity: Molecular Function Specific 49.90 60.3 51.7 68.9 3.7 0.4 1.9 0.9 0.2 0.2 CGI_10015453 PFMG7_Pinctada_fucata_AAZ76261.1 IPR018249: EF-HAND 2 Specific 49.59 35.1 26.4 43.8 1.5 0.0 1.9 0.7 0.0 0.1 CGI_10027474 Specific 49.37 179.2 130.9 227.5 9.9 0.6 8.7 2.3 0.1 0.1 CGI_10014784 Specific 49.19 13.4 10.2 16.7 1.1 0.0 0.4 0.0 0.0 0.2 CGI_10021733 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR019791: Haem peroxidase, animal, subgroup" PXDN_XENTR Peroxidasin OS=Xenopus tropicalis GN=pxdn PE=2 SV=1 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process Specific 48.92 21.9 13.5 30.2 1.9 0.2 0.4 0.1 0.0 0.0 CGI_10004971 Specific 48.66 39.7 39.9 39.4 3.8 0.0 0.9 0.0 0.0 0.2 CGI_10023928 "IPR000172: Glucose-methanol-choline oxidoreductase, N-terminal; PR007867: Glucose-methanol-choline oxidoreductase, C-terminal" SDH_GLUOX L-sorbose 1-dehydrogenase OS=Gluconobacter oxydans PE=3 SV=1 "GO:0016614: oxidoreductase activity, acting on CH-OH group of donors: Molecular Function; O:0050660: FAD or FADH2 binding: Molecular Function" Specific 48.57 38.1 33.0 43.1 2.1 0.5 1.6 0.4 0.0 0.1 CGI_10007666 Specific 48.32 31.3 22.0 40.7 1.7 2.1 0.0 0.0 0.1 0.0 CGI_10012743 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function Specific 48.26 113.4 79.6 147.2 8.4 0.8 3.7 1.1 0.1 0.0 CGI_10003712 Specific 47.10 87.4 66.0 108.9 9.9 0.0 0.0 1.3 0.0 0.0 CGI_10010359 IPR008985: Concanavalin A-like lectin/glucanase Specific 46.99 353.5 280.4 426.7 25.0 1.4 11.2 3.2 0.7 3.7 CGI_10009071 IPR002110: Ankyrin repeat; PR020683: Ankyrin repeat-containing domain ANR12_HUMAN Ankyrin repeat domain-containing protein 12 OS=Homo sapiens GN=ANKRD12 PE=1 SV=3 GO:0005515: protein binding: Molecular Function Specific 46.87 9.9 8.5 11.4 0.4 0.3 0.3 0.3 0.0 0.0 CGI_10009826 Specific 46.76 69.4 47.6 91.3 5.0 0.7 0.8 1.1 0.5 0.9 CGI_10005483 Specific 46.40 24.1 14.8 33.3 1.4 0.5 0.3 0.2 0.2 0.5 CGI_10009988 "IPR000719: Protein kinase, catalytic domain; PR001054: Adenylyl cyclase class-3/4/guanylyl cyclase; PR001245: Serine-threonine/tyrosine-protein kinase; PR011009: Protein kinase-like domain; PR020635: Tyrosine-protein kinase, catalytic domain" ANPRA_HUMAN Atrial natriuretic peptide receptor A OS=Homo sapiens GN=NPR1 PE=2 SV=1 GO:0004672: protein kinase activity: Molecular Function; O:0005524: ATP binding: Molecular Function; O:0006468: protein phosphorylation: Biological Process; O:0009190: cyclic nucleotide biosynthetic process: Biological Process; O:0016849: phosphorus-oxygen lyase activity: Molecular Function; O:0023034: intracellular signaling pathway: Biological Process Specific 46.34 31.1 31.7 30.6 1.3 0.4 1.4 0.4 0.2 0.4 CGI_10008021 Specific 45.95 20.1 18.2 22.0 1.5 0.3 0.6 0.2 0.0 0.0 CGI_10018416 Specific 45.91 13.4 12.3 14.5 1.2 0.0 0.0 0.2 0.4 0.0 CGI_10013178 IPR000157: Toll-Interleukin receptor TOLL_DROME Protein toll OS=Drosophila melanogaster GN=Tl PE=1 SV=1 GO:0004888: transmembrane receptor activity: Molecular Function; O:0007165: signal transduction: Biological Process; O:0031224: intrinsic to membrane: Cellular Component; O:0045087: innate immune response: Biological Process Specific 45.86 7.5 5.5 9.5 0.5 0.3 0.1 0.1 0.0 0.0 CGI_10010526 TEMPT_APLCA Temptin OS=Aplysia californica PE=1 SV=1 Specific 45.69 75.2 58.4 91.9 5.8 0.0 0.4 0.4 3.0 0.2 CGI_10021520 IPR001734: Sodium/solute symporter SC5A8_HUMAN Sodium-coupled monocarboxylate transporter 1 OS=Homo sapiens GN=SLC5A8 PE=1 SV=1 GO:0005215: transporter activity: Molecular Function; O:0006810: transport: Biological Process; O:0016020: membrane: Cellular Component; O:0055085: transmembrane transport: Biological Process Specific 45.41 211.3 166.0 256.6 18.0 0.4 7.7 1.6 0.1 0.2 CGI_10007201 IPR000082: SEA Specific 45.00 32.0 28.0 35.9 2.4 0.2 1.4 0.2 0.0 0.0 CGI_10017085 Specific 44.95 13.5 11.6 15.4 1.1 0.0 0.6 0.0 0.0 0.0 CGI_10014498 "IPR002035: von Willebrand factor, type A; PR002557: Chitin binding domain; PR008985: Concanavalin A-like lectin/glucanase" COCA1_HUMAN Collagen alpha-1(XII) chain OS=Homo sapiens GN=COL12A1 PE=1 SV=2 GO:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 44.75 34.9 25.7 44.1 3.1 0.4 0.0 0.3 0.0 1.0 CGI_10017087 IPR002557: Chitin binding domain GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 44.69 70.7 53.1 88.2 5.7 0.7 2.5 0.5 0.0 0.1 CGI_10026711 IPR001356: Homeobox; PR009057: Homeodomain-like GSC_DROME Homeobox protein goosecoid OS=Drosophila melanogaster GN=Gsc PE=1 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" Specific 44.10 17.2 9.1 25.3 1.5 0.4 0.2 0.2 0.1 0.0 CGI_10018986 IPR006150: Cysteine-rich repeat Specific 43.85 211.4 171.5 251.3 17.0 2.7 5.3 1.3 1.3 1.4 CGI_10016884 HVCN1_CHICK Voltage-gated hydrogen channel 1 OS=Gallus gallus GN=HVCN1 PE=2 SV=1 Specific 43.69 32.9 30.3 35.5 2.0 1.5 0.4 0.4 0.2 0.0 CGI_10010131 Alkaline phosphatase "IPR001952: Alkaline phosphatase; PR017850: Alkaline-phosphatase-like, core domain" "PPBT_BOVIN Alkaline phosphatase, tissue-nonspecific isozyme OS=Bos taurus GN=ALPL PE=1 SV=2" GO:0003824: catalytic activity: Molecular Function; O:0008152: metabolic process: Biological Process; O:0016791: phosphatase activity: Molecular Function Specific 43.65 35.2 30.3 40.1 1.9 0.3 2.6 0.1 0.1 0.0 CGI_10027712 "IPR006210: Epidermal growth factor-like; PR006212: Furin-like repeat; PR009030: Growth factor, receptor" MEGF6_RAT Multiple epidermal growth factor-like domains 6 OS=Rattus norvegicus GN=Megf6 PE=1 SV=1 GO:0005515: protein binding: Molecular Function Specific 43.62 18.8 17.2 20.5 1.2 0.7 0.5 0.1 0.1 0.0 CGI_10021734 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR019791: Haem peroxidase, animal, subgroup" PXDN_HUMAN Peroxidasin homolog OS=Homo sapiens GN=PXDN PE=1 SV=2 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process Specific 43.38 12.1 6.1 18.2 0.9 0.2 0.2 0.2 0.1 0.1 CGI_10014988 Specific 43.02 14.6 7.6 21.5 1.1 0.4 0.0 0.2 0.0 0.4 CGI_10001297 "IPR000719: Protein kinase, catalytic domain; PR001054: Adenylyl cyclase class-3/4/guanylyl cyclase; PR001245: Serine-threonine/tyrosine-protein kinase; PR002290: Serine/threonine-protein kinase domain; PR011009: Protein kinase-like domain; PR011645: Haem NO binding associated; PR020635: Tyrosine-protein kinase, catalytic domain" ANPRB_HUMAN Atrial natriuretic peptide receptor B OS=Homo sapiens GN=NPR2 PE=1 SV=1 GO:0004383: guanylate cyclase activity: Molecular Function; O:0004672: protein kinase activity: Molecular Function; O:0004674: protein serine/threonine kinase activity: Molecular Function; O:0005524: ATP binding: Molecular Function; O:0006182: cGMP biosynthetic process: Biological Process; O:0006468: protein phosphorylation: Biological Process; O:0009190: cyclic nucleotide biosynthetic process: Biological Process; O:0016849: phosphorus-oxygen lyase activity: Molecular Function; O:0023034: intracellular signaling pathway: Biological Process Specific 42.96 32.0 25.7 38.3 2.1 0.8 1.0 0.2 0.1 0.2 CGI_10013454 "IPR000742: Epidermal growth factor-like, type 3; PR001881: EGF-like calcium-binding; PR002557: Chitin binding domain; PR003599: Immunoglobulin subtype; PR006209: EGF; PR006210: Epidermal growth factor-like; PR007110: Immunoglobulin-like; PR013091: EGF calcium-binding" FBP1_STRPU Fibropellin-1 OS=Strongylocentrotus purpuratus GN=EGF1 PE=1 SV=2 GO:0005509: calcium ion binding: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function Specific 42.88 9.9 8.8 11.1 0.6 0.3 0.2 0.1 0.1 0.1 CGI_10004970 Specific 42.82 44.5 49.3 39.6 2.2 1.3 2.2 0.3 0.2 0.1 CGI_10028272 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR019791: Haem peroxidase, animal, subgroup" PXDN_DROME Peroxidasin OS=Drosophila melanogaster GN=Pxn PE=1 SV=1 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process Specific 42.67 7.3 6.7 8.0 0.6 0.3 0.0 0.0 0.2 0.0 CGI_10014927 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR019791: Haem peroxidase, animal, subgroup" PXDN_HUMAN Peroxidasin homolog OS=Homo sapiens GN=PXDN PE=1 SV=2 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process Specific 42.46 6.9 7.8 5.9 0.5 0.4 0.0 0.1 0.0 0.1 CGI_10007514 IPR000566: Lipocalin/cytosolic fatty-acid binding protein; PR011038: Calycin-like GO:0005488: binding: Molecular Function Specific 42.09 42.9 23.5 62.4 5.6 0.0 0.0 0.4 0.1 0.0 CGI_10011733 Specific 40.95 13.7 8.4 19.0 1.3 0.2 0.2 0.1 0.0 0.2 CGI_10021076 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function Specific 40.43 13.4 7.5 19.4 1.5 0.3 0.0 0.1 0.1 0.0 CGI_10012944 Specific 40.26 13.9 8.4 19.4 1.2 0.3 0.1 0.4 0.1 0.0 CGI_10021305 "IPR000322: Glycoside hydrolase, family 31; PR017853: Glycoside hydrolase, catalytic core" K1161_HUMAN Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 "GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds: Molecular Function; O:0005975: carbohydrate metabolic process: Biological Process" Specific 39.88 14.1 13.7 14.5 1.1 0.4 0.5 0.1 0.0 0.0 CGI_10003868 Specific 35.97 6.4 3.1 9.7 0.5 0.6 0.0 0.0 0.0 0.0 CGI_10018232 Specific 33.91 35.9 20.4 51.4 2.2 3.1 0.1 0.7 0.2 0.0 CGI_10005572 Specific 28.15 19.9 17.2 22.7 1.0 2.8 0.3 0.2 0.0 0.0 CGI_10018720 Specific 26.00 5.6 5.0 6.2 0.2 1.1 0.0 0.0 0.0 0.0 CGI_10026240 "IPR000742: Epidermal growth factor-like, type 3; PR000859: CUB; PR000998: MAM domain; PR001506: Peptidase M12A, astacin; PR006026: Peptidase, metallopeptidase; PR006210: Epidermal growth factor-like; PR008985: Concanavalin A-like lectin/glucanase" BP10_PARLI Blastula protease 10 OS=Paracentrotus lividus GN=BP10 PE=2 SV=1 GO:0004222: metalloendopeptidase activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006508: proteolysis: Biological Process; O:0008237: metallopeptidase activity: Molecular Function; O:0008270: zinc ion binding: Molecular Function; O:0016020: membrane: Cellular Component high 141.11 6.6 3.6 9.6 0.3 0.0 0.0 0.0 0.0 0.0 CGI_10008022 high 132.65 5.1 5.8 4.4 0.2 0.0 0.0 0.0 0.0 0.0 CGI_10009443 IPR002172: LDLR class A repeat CAS4_EPHMU Short-chain collagen C4 (Fragment) OS=Ephydatia muelleri PE=2 SV=1 GO:0005515: protein binding: Molecular Function high 105.71 6.0 2.7 9.2 0.2 0.1 0.0 0.0 0.0 0.0 CGI_10004229 "IPR001134: Netrin domain; PR001820: Proteinase inhibitor I35, tissue inhibitor of metalloproteinase; PR008993: Tissue inhibitor of metalloproteinases-like, OB-fold" GO:0005515: protein binding: Molecular Function; O:0005578: proteinaceous extracellular matrix: Cellular Component; O:0008191: metalloendopeptidase inhibitor activity: Molecular Function high 85.00 6.0 6.4 5.5 0.1 0.1 0.0 0.1 0.1 0.0 CGI_10017545 IMSP-2_Crassostrea_gigas_AM868448[EST]_AM864770[EST] "IPR000742: Epidermal growth factor-like, type 3; PR001507: Endoglin/CD105 antigen; PR006210: Epidermal growth factor-like" TEN2_CHICK Teneurin-2 OS=Gallus gallus GN=ODZ2 PE=2 SV=1 GO:0005515: protein binding: Molecular Function high 76.03 31.0 25.3 36.8 1.9 0.0 0.2 0.3 0.0 0.0 CGI_10014179 "IPR001590: Peptidase M12B, ADAM/reprolysin" MIG17_CAEEL ADAM family mig-17 OS=Caenorhabditis elegans GN=mig-17 PE=1 SV=3 GO:0004222: metalloendopeptidase activity: Molecular Function; O:0006508: proteolysis: Biological Process high 46.04 29.6 19.8 39.4 2.5 0.4 0.4 0.6 0.0 0.1 CGI_10024229 high 43.95 116.1 88.5 143.7 9.5 1.0 4.0 1.3 0.0 0.1 CGI_10020517 high 42.91 94.3 69.5 119.0 8.5 1.7 2.0 0.9 0.1 0.0 CGI_10000706 high 42.72 21.3 20.5 22.1 1.4 0.1 1.3 0.2 0.0 0.0 CGI_10004105 high 42.54 577.1 510.0 644.2 43.5 0.2 33.0 3.2 0.4 1.1 CGI_10023506 "IPR005084: Carbohydrate binding domain, family 6" GO:0030246: carbohydrate binding: Molecular Function high 42.53 62.9 64.2 61.7 3.7 0.5 4.6 0.1 0.0 0.1 CGI_10007200 "IPR002557: Chitin binding domain; PR013162: CD80-like, immunoglobulin C2-set" GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function high 42.42 48.6 44.4 52.9 2.8 0.2 3.3 0.5 0.1 0.1 CGI_10008122 IPR008985: Concanavalin A-like lectin/glucanase high 42.20 40.3 31.1 49.5 2.4 0.3 1.3 1.6 0.0 0.1 CGI_10009569 PRAX_HUMAN Periaxin OS=Homo sapiens GN=PRX PE=1 SV=1 high 41.70 129.3 116.7 142.0 9.5 0.4 6.7 0.8 0.6 0.7 CGI_10018725 "IPR002223: Proteinase inhibitor I2, Kunitz metazoa" APLP2_RAT Amyloid-like protein 2 OS=Rattus norvegicus GN=Aplp2 PE=2 SV=2 GO:0004867: serine-type endopeptidase inhibitor activity: Molecular Function high 41.33 241.7 221.7 261.8 12.9 4.4 14.4 1.6 0.5 1.3 CGI_10005749 IMSP-3_Crassostrea_gigas_CU683718[EST] M130_STRPU Mesenchyme-specific cell surface glycoprotein OS=Strongylocentrotus purpuratus PE=2 SV=2 high 41.20 29.0 16.0 41.9 2.4 0.7 0.4 0.5 0.2 0.0 CGI_10014928 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase" PXDN_XENTR Peroxidasin OS=Xenopus tropicalis GN=pxdn PE=2 SV=1 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process high 40.93 15.4 15.9 14.8 1.2 0.4 0.1 0.2 0.1 0.3 CGI_10010178 high 40.91 66.1 54.3 78.0 5.2 0.3 3.7 0.4 0.1 0.1 CGI_10007555 high 40.76 15.2 11.4 18.9 2.1 0.0 0.0 0.1 0.0 0.0 CGI_10016964 IMSP-7_Crassostrea_gigas_CU683357[EST] "IPR003961: Fibronectin, type III; PR008957: Fibronectin type III domain" LAR_DROME Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 GO:0005515: protein binding: Molecular Function high 40.21 45.2 33.2 57.2 5.6 0.4 0.2 0.4 0.3 0.0 CGI_10007670 high 38.96 172.4 116.8 228.0 24.6 0.0 0.4 1.4 0.2 0.0 CGI_10021357 "IPR008993: Tissue inhibitor of metalloproteinases-like, OB-fold; PR018933: Netrin module, non-TIMP type" high 38.85 17.1 9.9 24.3 1.5 0.2 0.5 0.2 0.0 0.2 CGI_10005772 high 38.19 11.8 9.7 13.9 1.0 0.0 0.3 0.6 0.0 0.0 CGI_10014593 IPR002645: Sulphate transporter/antisigma-factor antagonist STAS; PR011547: Sulphate transporter S26A5_HUMAN Prestin OS=Homo sapiens GN=SLC26A5 PE=2 SV=1 GO:0005215: transporter activity: Molecular Function; O:0006810: transport: Biological Process; O:0016021: integral to membrane: Cellular Component; O:0055085: transmembrane transport: Biological Process high 38.08 239.1 199.7 278.6 18.9 1.3 14.9 1.4 0.0 1.1 CGI_10027472 "IPR002509: Polysaccharide deacetylase; PR011330: Glycoside hydrolase/deacetylase, beta/alpha-barrel" "GO:0003824: catalytic activity: Molecular Function; O:0005975: carbohydrate metabolic process: Biological Process; O:0016810: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds: Molecular Function" high 37.90 22.0 16.9 27.2 1.6 0.4 1.2 0.1 0.1 0.1 CGI_10024748 "IPR004302: Chitin-binding, domain 3" GO:0019028: viral capsid: Cellular Component high 37.48 19.2 18.9 19.6 2.1 0.2 0.6 0.2 0.0 0.0 CGI_10018584 high 36.98 6.8 6.6 7.0 0.2 0.0 0.0 0.9 0.0 0.0 CGI_10016965 IMSP-7_Crassostrea_gigas_CU683357[EST] "IPR003961: Fibronectin, type III; PR008957: Fibronectin type III domain" LAR_DROME Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 GO:0005515: protein binding: Molecular Function high 36.92 301.7 241.9 361.5 18.5 1.7 9.5 3.0 15.1 1.2 CGI_10002192 high 36.65 75.5 63.5 87.5 4.8 1.2 4.7 0.4 0.4 1.0 CGI_10004086 "IPR002035: von Willebrand factor, type A; PR002557: Chitin binding domain" GO:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function high 36.41 14.8 12.2 17.4 1.3 0.3 0.5 0.1 0.1 0.1 CGI_10018297 PFMG12_Pinctada_fucata_AAZ22321.1 "IPR002223: Proteinase inhibitor I2, Kunitz metazoa; PR008197: Whey acidic protein, 4-disulphide core; PR015874: 4-disulphide core" IVBI_AUSLA Putative Kunitz-type proteinase inhibitor OS=Austrelaps labialis PE=2 SV=1 GO:0004867: serine-type endopeptidase inhibitor activity: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0030414: peptidase inhibitor activity: Molecular Function high 35.70 63.2 52.4 74.0 4.5 2.2 2.8 0.6 0.4 0.2 CGI_10004218 high 35.69 9.1 0.8 17.5 1.3 0.0 0.2 0.0 0.0 0.0 CGI_10003966 "IPR000742: Epidermal growth factor-like, type 3; PR000998: MAM domain; PR006209: EGF; PR006210: Epidermal growth factor-like; PR008985: Concanavalin A-like lectin/glucanase" MDGA2_HUMAN MAM domain-containing glycosylphosphatidylinositol anchor protein 2 OS=Homo sapiens GN=MDGA2 PE=2 SV=2 GO:0005515: protein binding: Molecular Function; O:0016020: membrane: Cellular Component high 34.89 5.5 3.5 7.6 0.5 0.3 0.1 0.0 0.0 0.1 CGI_10007669 high 34.87 76.8 47.8 105.8 11.1 0.8 0.0 1.0 0.2 0.2 CGI_10016790 "IPR001820: Proteinase inhibitor I35, tissue inhibitor of metalloproteinase; PR008993: Tissue inhibitor of metalloproteinases-like, OB-fold" GO:0005578: proteinaceous extracellular matrix: Cellular Component; O:0008191: metalloendopeptidase inhibitor activity: Molecular Function high 34.42 35.5 39.0 32.0 3.3 0.0 2.4 0.5 0.0 0.0 CGI_10024233 HAAF_LIMPO Hemagglutinin/amebocyte aggregation factor OS=Limulus polyphemus PE=1 SV=1 high 34.37 227.4 172.7 282.1 13.5 8.1 4.8 7.2 0.5 5.6 CGI_10009442 IPR002172: LDLR class A repeat; PR006210: Epidermal growth factor-like GO:0005515: protein binding: Molecular Function high 33.87 6.0 3.7 8.4 0.6 0.2 0.1 0.0 0.2 0.0 CGI_10016585 IPR002048: Calcium-binding EF-hand; PR018248: EF-hand; PR018249: EF-HAND 2 CML11_ARATH Calmodulin-like protein 11 OS=Arabidopsis thaliana GN=CML11 PE=2 SV=1 GO:0005509: calcium ion binding: Molecular Function high 33.35 5.2 9.0 1.3 0.3 0.1 0.4 0.0 0.1 0.0 CGI_10003924 "IPR000742: Epidermal growth factor-like, type 3; PR000859: CUB; PR001881: EGF-like calcium-binding; PR003599: Immunoglobulin subtype; PR006210: Epidermal growth factor-like; PR007110: Immunoglobulin-like; PR013091: EGF calcium-binding" NOTCH_DROME Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 GO:0005509: calcium ion binding: Molecular Function; O:0005515: protein binding: Molecular Function high 33.31 5.4 7.3 3.6 0.5 0.1 0.4 0.0 0.0 0.0 CGI_10009920 high 32.96 7.5 5.7 9.3 1.1 0.0 0.0 0.0 0.3 0.0 CGI_10020516 high 32.85 62.5 49.7 75.3 5.6 3.3 1.5 0.1 0.8 0.2 CGI_10016147 IPR002110: Ankyrin repeat; PR020683: Ankyrin repeat-containing domain ANK2_MOUSE Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 GO:0005515: protein binding: Molecular Function high 32.70 8.8 6.6 10.9 0.8 0.4 0.3 0.0 0.0 0.1 CGI_10023958 IPR019019: H-type lectin domain GO:0005529: sugar binding: Molecular Function; O:0007155: cell adhesion: Biological Process high 32.31 121.6 163.8 79.4 8.5 0.4 10.9 0.9 0.4 1.5 CGI_10013417 "IPR001599: Alpha-2-macroglobulin; PR008930: Terpenoid cylases/protein prenyltransferase alpha-alpha toroid; PR009048: Alpha-macroglobulin, receptor-binding; PR011626: A-macroglobulin complement component; PR019565: Alpha-2-macroglobulin, thiol-ester bond-forming" PZP_HUMAN Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=3 GO:0004866: endopeptidase inhibitor activity: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0005615: extracellular space: Cellular Component high 32.29 9.7 5.8 13.7 0.7 0.2 0.1 0.1 0.5 0.2 CGI_10008737 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function high 32.26 15.1 15.4 14.8 1.3 0.7 0.3 0.3 0.1 0.2 CGI_10025189 "IPR001356: Homeobox; PR009057: Homeodomain-like; PR020479: Homeobox, eukaryotic" SLOU_DROME Homeobox protein slou OS=Drosophila melanogaster GN=slou PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 32.06 15.9 8.8 23.1 1.0 0.8 0.3 0.4 0.3 0.2 CGI_10015398 high 32.01 372.0 320.4 423.6 40.2 9.6 14.5 2.7 2.5 0.4 CGI_10020612 high 31.50 120.1 101.9 138.3 16.3 0.6 4.9 0.9 0.2 0.0 CGI_10018176 high 31.28 84.4 68.5 100.3 7.1 4.4 4.0 0.8 0.0 0.0 CGI_10005098 high 31.13 22.1 30.9 13.3 0.5 0.2 3.4 0.1 0.0 0.0 CGI_10015320 "IPR002018: Carboxylesterase, type B" PNBA_BACSU Para-nitrobenzyl esterase OS=Bacillus subtilis GN=pnbA PE=1 SV=2 high 30.94 39.7 30.6 48.7 3.3 1.6 1.4 1.3 0.2 0.0 CGI_10006884 high 30.85 54.0 43.7 64.3 5.2 0.4 1.9 0.1 2.1 0.9 CGI_10026985 IPR001190: Speract/scavenger receptor; PR017448: Speract/scavenger receptor-related DMBT1_HUMAN Deleted in malignant brain tumors 1 protein OS=Homo sapiens GN=DMBT1 PE=1 SV=2 GO:0005044: scavenger receptor activity: Molecular Function; O:0016020: membrane: Cellular Component high 30.83 43.5 34.8 52.3 2.4 2.0 2.0 0.7 1.2 0.1 CGI_10017835 high 30.46 5.3 4.3 6.3 0.4 0.2 0.1 0.0 0.0 0.4 CGI_10018175 high 30.28 108.1 85.4 130.8 9.2 5.5 5.4 1.4 0.0 0.0 CGI_10018988 high 30.13 12.9 12.1 13.8 1.2 0.2 0.2 0.2 0.2 0.5 CGI_10021843 "IPR001820: Proteinase inhibitor I35, tissue inhibitor of metalloproteinase; PR008993: Tissue inhibitor of metalloproteinases-like, OB-fold" TIMP4_RAT Metalloproteinase inhibitor 4 OS=Rattus norvegicus GN=Timp4 PE=2 SV=2 GO:0005578: proteinaceous extracellular matrix: Cellular Component; O:0008191: metalloendopeptidase inhibitor activity: Molecular Function high 29.59 20.0 19.9 20.2 2.5 0.5 0.7 0.1 0.4 0.0 CGI_10022918 RTBS_DROME Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 high 29.19 12.8 11.6 14.0 1.0 0.2 0.5 0.5 0.2 0.2 CGI_10024373 high 28.83 25.3 19.8 30.8 1.1 0.5 3.0 0.0 0.0 0.7 CGI_10015319 high 28.65 56.2 45.3 67.1 4.1 0.9 3.1 2.3 1.4 0.0 CGI_10020607 high 28.42 99.7 65.1 134.4 1.5 0.8 0.2 18.3 0.0 0.3 CGI_10006371 IPR001190: Speract/scavenger receptor; PR017448: Speract/scavenger receptor-related HIPL1_MOUSE HHIP-like protein 1 OS=Mus musculus GN=Hhipl1 PE=2 SV=1 GO:0005044: scavenger receptor activity: Molecular Function; O:0016020: membrane: Cellular Component high 28.40 9.8 6.2 13.5 1.9 0.2 0.0 0.1 0.0 0.0 CGI_10003454 high 27.95 46.9 41.1 52.6 3.1 0.1 2.0 0.4 4.4 0.0 CGI_10020756 "IPR002223: Proteinase inhibitor I2, Kunitz metazoa" CO6A3_HUMAN Collagen alpha-3(VI) chain OS=Homo sapiens GN=COL6A3 PE=1 SV=4 GO:0004867: serine-type endopeptidase inhibitor activity: Molecular Function high 27.66 6.0 4.1 7.9 0.7 0.6 0.0 0.0 0.0 0.0 CGI_10001043 high 27.33 32.9 26.1 39.7 3.3 2.0 1.3 0.3 0.4 0.0 CGI_10018711 IPR002557: Chitin binding domain GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function high 27.07 198.2 180.9 215.6 13.4 7.9 16.1 2.3 0.5 3.7 CGI_10026432 high 26.83 26.0 24.7 27.3 2.2 1.3 0.9 0.0 0.1 1.4 CGI_10023081 IPR004031: PMP-22/EMP/MP20/Claudin GO:0016020: membrane: Cellular Component high 26.73 8.8 6.9 10.8 0.8 0.4 0.3 0.1 0.0 0.5 CGI_10010833 high 26.60 60.7 44.4 77.0 3.7 2.9 1.7 1.4 2.6 1.5 CGI_10009318 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis elegans GN=tyr-3 PE=2 SV=5 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function high 26.57 33.9 25.7 42.1 5.5 0.3 1.1 0.4 0.0 0.5 CGI_10016233 high 26.48 5.1 4.6 5.6 0.4 0.1 0.0 0.5 0.1 0.1 CGI_10024866 IPR019169: Transmembrane protein 26 TMM26_HUMAN Transmembrane protein 26 OS=Homo sapiens GN=TMEM26 PE=1 SV=1 high 26.40 8.8 8.9 8.6 0.2 0.8 0.6 0.1 0.0 0.4 CGI_10007529 IPR001356: Homeobox; PR009057: Homeodomain-like UNC4_DANRE Homeobox protein unc-4 homolog OS=Danio rerio GN=uncx PE=2 SV=2 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 25.91 24.4 12.5 36.3 2.6 0.5 2.2 0.2 0.0 0.2 CGI_10008399 "IPR000742: Epidermal growth factor-like, type 3" GO:0005515: protein binding: Molecular Function high 24.98 11.7 7.0 16.4 2.8 0.0 0.0 0.0 0.0 0.0 CGI_10006505 high 24.86 59.0 42.5 75.5 5.8 2.5 1.6 1.3 1.1 1.9 CGI_10005637 high 24.75 125.3 169.1 81.5 20.2 0.7 7.4 1.9 0.3 0.0 CGI_10016853 high 24.67 25.8 17.4 34.2 1.7 0.0 2.6 1.6 0.0 0.4 CGI_10010834 high 24.60 22.9 23.0 22.7 2.0 0.0 1.7 0.0 0.0 1.9 CGI_10018723 PCLO_HUMAN Protein piccolo OS=Homo sapiens GN=PCLO PE=1 SV=3 high 24.32 10.3 13.6 7.1 1.0 1.4 0.0 0.2 0.0 0.0 CGI_10019465 high 24.04 388.8 368.5 409.0 22.7 1.2 10.4 3.0 57.7 2.1 CGI_10014364 high 23.95 50.4 43.0 57.9 9.4 0.7 1.8 0.4 0.3 0.1 CGI_10020875 high 23.91 7.9 5.6 10.1 0.8 1.2 0.0 0.0 0.0 0.0 CGI_10023178 IPR002110: Ankyrin repeat; PR020683: Ankyrin repeat-containing domain RAI14_RAT Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 GO:0005515: protein binding: Molecular Function high 23.79 51.0 41.7 60.2 5.1 1.2 1.6 1.3 1.7 2.0 CGI_10010023 IPR006150: Cysteine-rich repeat high 23.77 109.2 99.1 119.4 10.2 0.2 6.5 0.7 9.9 0.1 CGI_10010398 "IPR000047: Helix-turn-helix motif, lambda-like repressor; PR001356: Homeobox; PR009057: Homeodomain-like" LBX1_XENLA Transcription factor LBX1 OS=Xenopus laevis GN=lbx1 PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005634: nucleus: Cellular Component; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 23.38 42.2 28.8 55.6 0.9 0.2 9.0 0.6 0.2 0.1 CGI_10004938 high 22.94 5.4 3.8 7.0 0.2 0.4 0.0 0.2 0.0 0.7 CGI_10020904 IPR019169: Transmembrane protein 26 TMM26_HUMAN Transmembrane protein 26 OS=Homo sapiens GN=TMEM26 PE=1 SV=1 high 22.90 7.4 5.6 9.2 0.7 0.3 0.4 0.2 0.1 0.2 CGI_10008428 high 22.87 101.4 121.0 81.7 18.3 0.4 6.4 1.2 0.3 0.0 CGI_10017983 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR1_CAEEL Putative tyrosinase-like protein tyr-1 OS=Caenorhabditis elegans GN=tyr-1 PE=1 SV=2 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function high 22.75 8.8 4.9 12.7 0.8 0.2 0.0 0.1 1.1 0.1 CGI_10023851 "IPR002130: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; PR015891: Cyclophilin-like" PPIB_CHICK Peptidyl-prolyl cis-trans isomerase B OS=Gallus gallus GN=PPIB PE=2 SV=1 GO:0003755: peptidyl-prolyl cis-trans isomerase activity: Molecular Function; O:0006457: protein folding: Biological Process high 22.72 154.4 99.7 209.1 10.3 3.5 5.5 4.5 15.6 1.3 CGI_10014865 "IPR007527: Zinc finger, SWIM-type; PR013694: Vault protein inter-alpha-trypsin" GO:0008270: zinc ion binding: Molecular Function high 22.09 40.9 30.9 50.9 4.2 0.4 2.7 0.7 1.4 1.8 CGI_10014987 IPR002861: Reeler domain FRRS1_DANRE Putative ferric-chelate reductase 1 OS=Danio rerio GN=frrs1 PE=2 SV=1 high 21.99 7.0 5.6 8.3 0.6 0.8 0.1 0.1 0.2 0.1 CGI_10026219 high 21.94 137.4 107.6 167.3 14.3 7.5 4.1 1.3 4.4 6.0 CGI_10022682 high 21.68 88.5 51.7 125.3 8.4 3.6 2.1 0.6 0.6 9.3 CGI_10001565 high 21.50 5.3 4.3 6.4 0.8 0.3 0.0 0.0 0.4 0.0 CGI_10027573 high 20.75 25.4 19.7 31.0 1.5 4.3 0.2 0.3 0.8 0.3 CGI_10000913 "IPR000832: GPCR, family 2, secretin-like; PR017981: GPCR, family 2-like" LPHN3_HUMAN Latrophilin-3 OS=Homo sapiens GN=LPHN3 PE=1 SV=2 GO:0004888: transmembrane receptor activity: Molecular Function; O:0004930: G-protein coupled receptor activity: Molecular Function; O:0007166: cell surface receptor linked signaling pathway: Biological Process; O:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016020: membrane: Cellular Component high 20.62 9.5 7.5 11.5 1.0 1.5 0.2 0.1 0.0 0.0 CGI_10021073 "IPR000742: Epidermal growth factor-like, type 3; PR002049: EGF-like, laminin; PR002889: Carbohydrate-binding WSC; PR006210: Epidermal growth factor-like; PR008985: Concanavalin A-like lectin/glucanase; PR009030: Growth factor, receptor; PR013111: EGF, extracellular" MEGF6_HUMAN Multiple epidermal growth factor-like domains 6 OS=Homo sapiens GN=MEGF6 PE=2 SV=4 GO:0005515: protein binding: Molecular Function high 20.24 20.7 16.9 24.5 4.7 0.5 0.6 0.2 0.1 0.1 CGI_10016779 "IPR001841: Zinc finger, RING-type; PR018957: Zinc finger, C3HC4 RING-type" RN215_MOUSE RING finger protein 215 OS=Mus musculus GN=Rnf215 PE=2 SV=1 GO:0005515: protein binding: Molecular Function; O:0008270: zinc ion binding: Molecular Function high 20.09 96.2 54.9 137.5 10.2 4.6 2.9 3.2 3.4 4.5 CGI_10011317 high 20.00 6.8 5.3 8.2 0.8 0.4 0.2 0.0 0.2 0.6 CGI_10026671 "IPR000572: Oxidoreductase, molybdopterin-binding domain; PR001199: Cytochrome b5; PR002035: von Willebrand factor, type A; PR005066: Moybdenum cofactor oxidoreductase, dimerisation; PR006029: Neurotransmitter-gated ion-channel transmembrane domain; PR006201: Neurotransmitter-gated ion-channel; PR006202: Neurotransmitter-gated ion-channel ligand-binding; PR008335: Eukaryotic molybdopterin oxidoreductase; PR014756: Immunoglobulin E-set" "SUOX_DROME Probable sulfite oxidase, mitochondrial OS=Drosophila melanogaster GN=CG7280 PE=2 SV=1" GO:0005230: extracellular ligand-gated ion channel activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006810: transport: Biological Process; O:0006811: ion transport: Biological Process; O:0009055: electron carrier activity: Molecular Function; O:0016020: membrane: Cellular Component; O:0016021: integral to membrane: Cellular Component; O:0016491: oxidoreductase activity: Molecular Function; O:0020037: heme binding: Molecular Function; O:0030151: molybdenum ion binding: Molecular Function; O:0046872: metal ion binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process high 19.72 274.9 230.5 319.4 30.6 7.6 22.1 9.2 4.5 9.7 CGI_10023289 high 19.72 5.0 3.5 6.5 0.8 0.2 0.2 0.0 0.0 0.2 CGI_10020998 IPR002126: Cadherin; PR015919: Cadherin-like STAN_DROME Protocadherin-like wing polarity protein stan OS=Drosophila melanogaster GN=stan PE=1 SV=4 GO:0005509: calcium ion binding: Molecular Function; O:0007156: homophilic cell adhesion: Biological Process; O:0016020: membrane: Cellular Component high 19.52 6.6 4.5 8.8 1.0 0.9 0.0 0.1 0.0 0.1 CGI_10004749 "IPR002035: von Willebrand factor, type A; PR004010: Cache; PR013608: VWA N-terminal" CAHD1_HUMAN VWFA and cache domain-containing protein 1 OS=Homo sapiens GN=CACHD1 PE=1 SV=2 GO:0005515: protein binding: Molecular Function; O:0016020: membrane: Cellular Component high 19.36 5.2 4.2 6.2 0.6 0.3 0.2 0.1 0.1 0.3 CGI_10021072 "IPR000742: Epidermal growth factor-like, type 3; PR002889: Carbohydrate-binding WSC; PR006209: EGF; PR006210: Epidermal growth factor-like; PR012314: Peptidase M12B, GON-ADAMTSs; PR013994: Carbohydrate-binding WSC, subgroup" KREM1_MOUSE Kremen protein 1 OS=Mus musculus GN=Kremen1 PE=2 SV=1 GO:0004222: metalloendopeptidase activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005578: proteinaceous extracellular matrix: Cellular Component; O:0008270: zinc ion binding: Molecular Function high 18.97 18.7 14.5 23.0 4.2 0.4 1.2 0.1 0.0 0.0 CGI_10010445 "IPR002509: Polysaccharide deacetylase; PR011330: Glycoside hydrolase/deacetylase, beta/alpha-barrel" "GO:0003824: catalytic activity: Molecular Function; O:0005975: carbohydrate metabolic process: Biological Process; O:0016810: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds: Molecular Function" high 18.72 38.8 29.0 48.5 5.9 2.8 1.8 1.0 0.1 0.8 CGI_10025306 "IPR000719: Protein kinase, catalytic domain; PR001245: Serine-threonine/tyrosine-protein kinase; PR002290: Serine/threonine-protein kinase domain; PR003961: Fibronectin, type III; PR008957: Fibronectin type III domain; PR011009: Protein kinase-like domain; PR020635: Tyrosine-protein kinase, catalytic domain" FLT3_HUMAN FL cytokine receptor OS=Homo sapiens GN=FLT3 PE=1 SV=2 GO:0004672: protein kinase activity: Molecular Function; O:0004674: protein serine/threonine kinase activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005524: ATP binding: Molecular Function; O:0006468: protein phosphorylation: Biological Process high 18.72 9.2 8.7 9.8 0.9 0.3 0.7 0.1 0.2 0.7 CGI_10009319 Tyrosinase_Pinctada_fucata_AAZ66340.1 IPR002227: Tyrosinase; PR008922: Di-copper centre-containing TYR1_CAEEL Putative tyrosinase-like protein tyr-1 OS=Caenorhabditis elegans GN=tyr-1 PE=1 SV=2 GO:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function high 18.64 5.4 3.5 7.3 1.4 0.4 0.0 0.0 0.0 0.0 CGI_10027224 high 18.48 6.5 6.5 6.5 1.2 0.3 0.4 0.0 0.0 0.3 CGI_10008030 high 18.44 31.5 31.3 31.6 9.3 0.0 0.9 0.0 0.0 0.0 CGI_10006808 sarcoplasmic_calcium-binding_protein_Mizuhopecten_yessoensis_BAA89420.1 IPR002048: Calcium-binding EF-hand; PR018249: EF-HAND 2 SCP_PATYE Sarcoplasmic calcium-binding protein OS=Patinopecten yessoensis PE=1 SV=1 GO:0005509: calcium ion binding: Molecular Function high 18.35 7.4 3.5 11.2 0.3 0.8 0.0 1.2 0.0 0.2 CGI_10011057 "IPR002035: von Willebrand factor, type A; PR002557: Chitin binding domain" MATN2_MOUSE Matrilin-2 OS=Mus musculus GN=Matn2 PE=2 SV=1 GO:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function high 18.22 10.1 5.6 14.6 1.8 0.7 0.0 0.2 0.6 0.1 CGI_10005345 "IPR000033: LDLR class B repeat; PR001881: EGF-like calcium-binding; PR002172: LDLR class A repeat; PR006210: Epidermal growth factor-like; PR009030: Growth factor, receptor" LRP2_RAT Low-density lipoprotein receptor-related protein 2 OS=Rattus norvegicus GN=Lrp2 PE=1 SV=1 GO:0005509: calcium ion binding: Molecular Function; O:0005515: protein binding: Molecular Function; O:0016020: membrane: Cellular Component high 17.95 11.0 8.6 13.3 1.2 1.5 0.6 0.1 0.1 0.2 CGI_10020435 high 17.95 19.1 17.3 20.9 3.7 0.7 0.5 0.3 0.6 0.6 CGI_10004992 Carbonic_anhydrase_precursor_Tridacna_gigas_AAX16122.1 "IPR001148: Carbonic anhydrase, alpha-class, catalytic domain" CAHZ_DANRE Carbonic anhydrase OS=Danio rerio GN=cahz PE=1 SV=2 high 17.92 34.1 24.5 43.8 3.0 1.3 4.0 0.7 1.8 0.6 CGI_10009438 chitin synthase "IPR001609: Myosin head, motor domain; PR004835: Fungal chitin synthase" MYO3B_HUMAN Myosin-IIIB OS=Homo sapiens GN=MYO3B PE=2 SV=3 "GO:0003774: motor activity: Molecular Function; O:0005524: ATP binding: Molecular Function; O:0016459: myosin complex: Cellular Component; O:0016758: transferase activity, transferring hexosyl groups: Molecular Function" high 17.85 30.3 26.2 34.4 3.6 0.7 2.5 0.6 0.5 2.4 CGI_10019810 "IPR000315: Zinc finger, B-box" TRIM2_HUMAN Tripartite motif-containing protein 2 OS=Homo sapiens GN=TRIM2 PE=1 SV=1 GO:0005622: intracellular: Cellular Component; O:0008270: zinc ion binding: Molecular Function high 17.84 15.9 13.2 18.6 1.3 2.6 0.5 0.2 0.8 0.0 CGI_10011803 "IPR001179: Peptidyl-prolyl cis-trans isomerase, FKBP-type; PR018249: EF-HAND 2" FKBP7_MOUSE FK506-binding protein 7 OS=Mus musculus GN=Fkbp7 PE=1 SV=1 GO:0006457: protein folding: Biological Process high 17.60 7.8 4.7 10.9 0.4 1.3 0.1 0.0 0.8 0.1 CGI_10008927 "IPR000276: 7TM GPCR, rhodopsin-like; PR017452: GPCR, rhodopsin-like superfamily" GP174_MOUSE Probable G-protein coupled receptor 174 OS=Mus musculus GN=Gpr174 PE=2 SV=1 GO:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 17.49 13.6 15.1 12.0 1.1 2.6 0.7 0.0 0.2 0.0 CGI_10028652 high 17.16 270.3 198.8 341.7 33.5 6.7 27.3 3.1 1.6 22.2 CGI_10018952 high 16.99 201.1 197.2 204.9 15.2 6.3 13.6 1.4 30.7 3.8 CGI_10007887 high 16.91 158.6 100.7 216.4 12.3 3.5 0.0 1.4 0.3 38.8 CGI_10017798 IPR007110: Immunoglobulin-like GO:0005515: protein binding: Molecular Function high 16.60 19.2 13.2 25.1 1.8 4.2 0.3 0.1 0.1 0.4 CGI_10011162 HMU_HALWD Halomucin OS=Haloquadratum walsbyi (strain DSM 16790) GN=hmu PE=4 SV=1 high 16.57 6.9 5.4 8.5 1.0 0.0 0.4 0.3 0.4 0.5 CGI_10005481 high 16.41 16.0 7.3 24.7 1.5 3.7 0.7 0.0 0.0 0.0 CGI_10027370 high 16.19 5.9 4.7 7.2 0.6 0.3 0.4 0.1 0.2 0.5 CGI_10020140 high 16.04 14.4 28.0 0.8 0.5 0.1 4.2 0.2 0.4 0.0 CGI_10022232 "IPR001211: Phospholipase A2, eukaryotic; PR016090: Phospholipase A2" PA28_VIPPA Phospholipase A2 homolog VP8 OS=Vipera palaestinae PE=2 SV=1 GO:0004623: phospholipase A2 activity: Molecular Function; O:0005509: calcium ion binding: Molecular Function; O:0016042: lipid catabolic process: Biological Process high 15.72 46.5 45.7 47.4 4.3 1.3 3.8 0.3 7.0 1.0 CGI_10021028 "IPR014782: Peptidase M1, membrane alanine aminopeptidase, N-terminal" AMPN_PIG Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=3 GO:0008237: metallopeptidase activity: Molecular Function; O:0008270: zinc ion binding: Molecular Function high 15.69 27.9 35.2 20.6 3.6 1.4 4.4 0.2 0.1 0.9 CGI_10004231 "IPR001134: Netrin domain; PR001820: Proteinase inhibitor I35, tissue inhibitor of metalloproteinase; PR008993: Tissue inhibitor of metalloproteinases-like, OB-fold" GO:0005515: protein binding: Molecular Function; O:0005578: proteinaceous extracellular matrix: Cellular Component; O:0008191: metalloendopeptidase inhibitor activity: Molecular Function high 15.68 429.3 387.3 471.4 30.7 25.2 18.7 69.7 5.0 14.9 CGI_10023290 IPR002861: Reeler domain DFP3_ANTMY Putative defense protein 3 OS=Antheraea mylitta PE=2 SV=1 high 15.61 9.3 6.5 12.1 2.1 0.3 0.4 0.3 0.0 0.6 CGI_10008370 high 15.60 6.7 5.2 8.2 0.0 1.4 0.9 0.3 0.0 0.0 CGI_10021151 high 15.46 8.8 5.6 12.1 0.6 1.4 0.7 0.6 0.0 0.1 CGI_10021408 high 14.63 37.3 28.3 46.3 4.1 2.8 5.8 0.7 0.0 2.0 CGI_10022850 high 14.51 5.3 4.3 6.4 1.2 0.2 0.3 0.1 0.0 0.6 CGI_10004864 IPR001283: Allergen V5/Tpx-1-related; PR014044: CAP domain MR30_CONMR Cysteine-rich secretory protein Mr30 OS=Conus marmoreus PE=1 SV=1 GO:0005576: extracellular region: Cellular Component high 14.40 25.5 20.7 30.3 3.5 2.7 0.8 0.5 0.0 3.1 CGI_10009201 "IPR011105: Cell wall hydrolase, SleB" SLEB_OCEIH Spore cortex-lytic enzyme OS=Oceanobacillus iheyensis GN=sleB PE=3 SV=1 GO:0005618: cell wall: Cellular Component; O:0009847: spore germination: Biological Process; O:0016787: hydrolase activity: Molecular Function high 14.01 5.5 5.7 5.3 0.9 0.8 0.3 0.2 0.1 0.2 CGI_10005484 IPR001298: Filamin/ABP280 repeat; PR001715: Calponin homology domain; PR014756: Immunoglobulin E-set; PR017868: Filamin/ABP280 repeat-like FLNC_MOUSE Filamin-C OS=Mus musculus GN=Flnc PE=1 SV=3 GO:0005515: protein binding: Molecular Function high 13.85 25.9 23.0 28.8 3.9 1.7 2.0 0.3 0.0 3.3 CGI_10024083 "IPR000047: Helix-turn-helix motif, lambda-like repressor; PR001356: Homeobox; PR009057: Homeodomain-like; PR020479: Homeobox, eukaryotic" HXA1_XENLA Homeobox protein Hox-A1 (Fragment) OS=Xenopus laevis GN=hoxa1 PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005634: nucleus: Cellular Component; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 13.73 8.4 5.2 11.5 2.2 1.3 0.0 0.2 0.0 0.0 CGI_10025650 "IPR000276: 7TM GPCR, rhodopsin-like; PR017452: GPCR, rhodopsin-like superfamily" SSR4_RAT Somatostatin receptor type 4 OS=Rattus norvegicus GN=Sstr4 PE=2 SV=1 GO:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 13.67 5.0 4.4 5.5 0.7 0.0 0.7 0.1 0.1 0.5 CGI_10021743 high 13.56 11.2 21.5 0.9 0.4 1.3 3.3 0.0 0.0 0.0 CGI_10025038 "IPR011105: Cell wall hydrolase, SleB" SLEB_BACSU Spore cortex-lytic enzyme OS=Bacillus subtilis GN=sleB PE=1 SV=1 GO:0005618: cell wall: Cellular Component; O:0009847: spore germination: Biological Process; O:0016787: hydrolase activity: Molecular Function high 13.46 33.4 33.9 33.0 3.3 3.9 1.4 0.0 0.0 6.4 CGI_10007693 "IPR000832: GPCR, family 2, secretin-like; PR001879: GPCR, family 2, extracellular hormone receptor domain" GO:0004930: G-protein coupled receptor activity: Molecular Function; O:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016020: membrane: Cellular Component high 13.37 6.8 4.5 9.1 1.2 0.7 0.0 0.0 0.2 1.0 CGI_10027254 "IPR003020: Bicarbonate transporter, eukaryotic; PR003024: Sodium bicarbonate cotransporter; PR011531: Bicarbonate transporter, C-terminal; PR013769: Bicarbonate transporter, cytoplasmic; PR016152: Phosphotransferase/anion transporter" S4A8_HUMAN Electroneutral sodium bicarbonate exchanger 1 OS=Homo sapiens GN=SLC4A8 PE=1 SV=1 GO:0005215: transporter activity: Molecular Function; O:0005452: inorganic anion exchanger activity: Molecular Function; O:0006810: transport: Biological Process; O:0006820: anion transport: Biological Process; O:0008509: anion transmembrane transporter activity: Molecular Function; O:0016020: membrane: Cellular Component; O:0016021: integral to membrane: Cellular Component high 13.36 169.4 114.4 224.4 12.4 48.1 6.6 1.1 1.6 6.3 CGI_10003100 K1199_MOUSE Protein KIAA1199 homolog OS=Mus musculus PE=2 SV=3 high 13.30 11.3 8.2 14.4 1.3 0.6 1.5 0.6 0.1 1.0 CGI_10003766 IPR000488: Death; PR001368: TNFR/CD27/30/40/95 cysteine-rich region; PR011029: DEATH-like TNR16_MOUSE Tumor necrosis factor receptor superfamily member 16 OS=Mus musculus GN=Ngfr PE=1 SV=1 GO:0004872: receptor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0007165: signal transduction: Biological Process high 13.25 14.7 8.9 20.6 2.5 0.7 1.3 0.4 0.2 1.5 CGI_10002524 "IPR000323: Copper type II, ascorbate-dependent monooxygenase, N-terminal; PR008977: PHM/PNGase F-fold domain" DOPO_HORSE Dopamine beta-hydroxylase OS=Equus caballus GN=DBH PE=2 SV=1 GO:0003824: catalytic activity: Molecular Function; O:0004497: monooxygenase activity: Molecular Function; O:0005507: copper ion binding: Molecular Function; O:0009987: cellular process: Biological Process high 13.05 6.8 6.9 6.7 0.3 0.5 0.1 0.2 2.1 0.0 CGI_10010153 PFMG9_Pinctada_fucata_AAZ22318.1 "IPR002350: Proteinase inhibitor I1, Kazal; PR011497: Protease inhibitor, Kazal-type" DPGN_DIPMA Serine protease inhibitor dipetalogastin (Fragment) OS=Dipetalogaster maximus PE=1 SV=2 GO:0005515: protein binding: Molecular Function high 13.00 15.3 8.3 22.2 0.5 1.2 5.1 0.3 0.0 0.0 CGI_10008033 high 12.81 12.0 12.2 11.9 5.2 0.0 0.4 0.0 0.0 0.0 CGI_10011763 "IPR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR019791: Haem peroxidase, animal, subgroup" PXDN_XENTR Peroxidasin OS=Xenopus tropicalis GN=pxdn PE=2 SV=1 GO:0004601: peroxidase activity: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process high 12.71 6.4 8.7 4.2 1.1 0.3 0.4 0.1 0.9 0.3 CGI_10024086 "IPR001356: Homeobox; PR009057: Homeodomain-like; PR020479: Homeobox, eukaryotic" HXA2_BOVIN Homeobox protein Hox-A2 OS=Bos taurus GN=HOXA2 PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 12.57 9.0 9.7 8.3 1.6 0.3 2.3 0.1 0.0 0.1 CGI_10018362 IPR002909: Cell surface receptor IPT/TIG; PR008972: Cupredoxin; PR011050: Pectin lyase fold/virulence factor; PR014756: Immunoglobulin E-set; PR019316: G8 domain PKHL1_MOUSE Fibrocystin-L OS=Mus musculus GN=Pkhd1l1 PE=2 SV=1 GO:0005515: protein binding: Molecular Function high 12.51 11.5 5.9 17.1 1.3 2.3 0.4 0.4 0.8 0.4 CGI_10007682 "IPR009048: Alpha-macroglobulin, receptor-binding" GO:0005576: extracellular region: Cellular Component high 12.50 25.1 22.5 27.8 9.7 0.6 1.5 0.2 0.0 0.0 CGI_10003320 "IPR011497: Protease inhibitor, Kazal-type" high 12.38 47.8 43.9 51.8 4.6 5.0 4.0 1.4 2.8 5.4 CGI_10006749 IPR002657: Bile acid:sodium symporter NTCP2_RAT Ileal sodium/bile acid cotransporter OS=Rattus norvegicus GN=Slc10a2 PE=2 SV=1 GO:0006814: sodium ion transport: Biological Process; O:0008508: bile acid:sodium symporter activity: Molecular Function; O:0016020: membrane: Cellular Component high 12.32 9.4 9.2 9.6 1.7 1.8 0.8 0.0 0.0 0.2 CGI_10018746 IPR002937: Amine oxidase high 12.28 23.2 13.2 33.3 4.1 5.5 0.4 0.4 0.8 0.1 CGI_10026457 "IPR000269: Copper amine oxidase; PR015798: Copper amine oxidase, C-terminal; PR016182: Copper amine oxidase, N-terminal" AOC3_RAT Membrane primary amine oxidase OS=Rattus norvegicus GN=Aoc3 PE=1 SV=4 GO:0005507: copper ion binding: Molecular Function; O:0008131: primary amine oxidase activity: Molecular Function; O:0009308: amine metabolic process: Biological Process; O:0048038: quinone binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process high 12.05 25.6 18.2 32.9 2.9 4.8 0.3 0.3 3.8 0.7 CGI_10016204 IPR003378: Fringe-like C1GLT_HUMAN Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Homo sapiens GN=C1GALT1 PE=1 SV=1 "GO:0016020: membrane: Cellular Component; O:0016757: transferase activity, transferring glycosyl groups: Molecular Function" high 11.96 17.5 22.6 12.5 3.1 4.3 0.8 0.3 0.3 0.0 CGI_10021029 high 11.86 24.5 29.4 19.6 3.6 0.9 6.8 0.0 0.0 1.2 CGI_10024018 high 11.75 5.0 4.2 5.8 1.7 0.3 0.2 0.3 0.0 0.0 CGI_10002657 high 11.72 24.4 27.5 21.3 1.4 0.3 8.9 0.3 0.1 1.5 CGI_10008601 "IPR001926: Pyridoxal phosphate-dependent enzyme, beta subunit" SDSL_HUMAN Serine dehydratase-like OS=Homo sapiens GN=SDSL PE=1 SV=1 GO:0003824: catalytic activity: Molecular Function; O:0008152: metabolic process: Biological Process; O:0030170: pyridoxal phosphate binding: Molecular Function high 11.64 44.1 27.0 61.3 2.9 2.6 3.9 7.8 0.0 5.6 CGI_10011684 IPR001734: Sodium/solute symporter SC5AB_RABIT Sodium/myo-inositol cotransporter 2 OS=Oryctolagus cuniculus GN=SLC5A11 PE=1 SV=2 GO:0005215: transporter activity: Molecular Function; O:0006810: transport: Biological Process; O:0016020: membrane: Cellular Component; O:0055085: transmembrane transport: Biological Process high 11.62 5.4 2.1 8.6 0.6 1.2 0.5 0.1 0.1 0.2 CGI_10026230 Tyrosinase_Pinctada_fucata_AAZ66340.1 "IPR001650: Helicase, C-terminal; PR002227: Tyrosinase; PR008922: Di-copper centre-containing" TYR1_CAEEL Putative tyrosinase-like protein tyr-1 OS=Caenorhabditis elegans GN=tyr-1 PE=1 SV=2 GO:0003676: nucleic acid binding: Molecular Function; O:0004386: helicase activity: Molecular Function; O:0005524: ATP binding: Molecular Function; O:0008152: metabolic process: Biological Process; O:0016491: oxidoreductase activity: Molecular Function high 11.60 9.7 8.3 11.1 1.4 2.6 0.2 0.3 0.3 0.2 CGI_10027166 high 11.52 15.2 11.6 18.8 2.1 1.4 1.9 0.2 0.0 2.3 CGI_10015955 high 11.33 5.2 4.0 6.5 0.0 0.0 1.8 0.0 0.0 1.0 CGI_10003101 high 11.28 11.8 9.1 14.5 0.7 1.5 1.6 0.6 0.0 1.8 CGI_10017136 "IPR003859: Galactosyltransferase, metazoa" "BRE4_CAEEL Beta-1,4-N-acetylgalactosaminyltransferase bre-4 OS=Caenorhabditis elegans GN=bre-4 PE=1 SV=1" "GO:0005975: carbohydrate metabolic process: Biological Process; O:0016757: transferase activity, transferring glycosyl groups: Molecular Function" high 11.04 19.3 17.7 20.9 1.5 0.0 1.2 0.1 0.4 7.4 CGI_10005968 "IPR000327: POU-specific; PR001356: Homeobox; PR009057: Homeodomain-like; PR010982: Lambda repressor-like, DNA-binding; PR013847: POU" "PO3F4_RAT POU domain, class 3, transcription factor 4 OS=Rattus norvegicus GN=Pou3f4 PE=2 SV=1" "GO:0003677: DNA binding: Molecular Function; O:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 10.99 69.5 54.1 85.0 5.3 8.2 11.8 2.3 5.0 5.4 CGI_10020694 IPR001304: C-type lectin; PR016187: C-type lectin fold MMGL_RAT Macrophage asialoglycoprotein-binding protein OS=Rattus norvegicus GN=Mgl1 PE=1 SV=1 GO:0005488: binding: Molecular Function high 10.87 176.0 117.9 234.1 90.2 1.6 2.8 1.6 1.0 0.0 CGI_10018677 high 10.85 11.0 6.7 15.4 0.0 0.0 4.0 0.0 0.0 2.1 CGI_10025757 "IPR000421: Coagulation factor 5/8 type, C-terminal; PR001254: Peptidase S1/S6, chymotrypsin/Hap; PR001314: Peptidase S1A, chymotrypsin-type; PR008979: Galactose-binding domain-like; PR009003: Peptidase cysteine/serine, trypsin-like" KLKB1_BOVIN Plasma kallikrein OS=Bos taurus GN=KLKB1 PE=2 SV=1 GO:0003824: catalytic activity: Molecular Function; O:0004252: serine-type endopeptidase activity: Molecular Function; O:0006508: proteolysis: Biological Process; O:0007155: cell adhesion: Biological Process high 10.32 77.8 54.3 101.4 13.2 22.8 4.7 2.2 1.1 1.4 CGI_10023979 "IPR001356: Homeobox; PR009057: Homeodomain-like; PR020479: Homeobox, eukaryotic" HOX71_XENLA Homeobox protein XHOX-7.1 (Fragment) OS=Xenopus laevis PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 10.27 94.7 69.1 120.4 3.4 0.8 10.4 39.6 1.1 0.1 CGI_10024084 high 10.25 12.2 7.7 16.7 4.4 2.4 0.0 0.1 0.3 0.0 CGI_10014971 G_protein_a_subunit_s_class_Pinctada_fucata_Q6TP31 "IPR000367: G-protein alpha subunit, group S; PR001019: Guanine nucleotide binding protein (G-protein), alpha subunit; PR011025: G protein alpha subunit, helical insertion" GNAS_ANOGA Guanine nucleotide-binding protein G(s) subunit alpha OS=Anopheles gambiae GN=G-s-alpha-60A PE=2 SV=1 GO:0004871: signal transducer activity: Molecular Function; O:0005525: GTP binding: Molecular Function; O:0007165: signal transduction: Biological Process; O:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0019001: guanyl nucleotide binding: Molecular Function high 10.19 31.5 30.2 32.9 8.5 7.8 1.6 0.3 0.3 0.1 CGI_10023542 "IPR011105: Cell wall hydrolase, SleB" SLEB_BACSU Spore cortex-lytic enzyme OS=Bacillus subtilis GN=sleB PE=1 SV=1 GO:0005618: cell wall: Cellular Component; O:0009847: spore germination: Biological Process; O:0016787: hydrolase activity: Molecular Function high 10.10 34.9 36.5 33.3 4.4 6.7 2.5 0.0 0.0 7.2 CGI_10008548 IPR001991: Sodium:dicarboxylate symporter EAAT_ONCVO Excitatory amino acid transporter OS=Onchocerca volvulus GN=GLT-1 PE=2 SV=1 GO:0006835: dicarboxylic acid transport: Biological Process; O:0016020: membrane: Cellular Component; O:0017153: sodium:dicarboxylate symporter activity: Molecular Function high 10.06 23.1 12.1 34.1 4.0 5.6 1.5 0.8 1.0 1.0 CGI_10007129 "IPR001781: Zinc finger, LIM-type; PR002931: Transglutaminase-like" KY_MOUSE Kyphoscoliosis peptidase OS=Mus musculus GN=Ky PE=1 SV=1 GO:0008270: zinc ion binding: Molecular Function high 9.99 21.0 14.8 27.2 2.3 2.1 0.9 3.5 0.2 3.5 CGI_10007162 "IPR000276: 7TM GPCR, rhodopsin-like; PR017452: GPCR, rhodopsin-like superfamily" YR13_CAEEL Probable G-protein coupled receptor T27D1.3 OS=Caenorhabditis elegans GN=T27D1.3 PE=2 SV=3 GO:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 9.84 13.6 10.5 16.8 1.4 1.4 5.0 0.2 0.0 0.4 CGI_10016115 "IPR007087: Zinc finger, C2H2-type; PR015880: Zinc finger, C2H2-like" ZIC4_XENLA Zinc finger protein ZIC 4 OS=Xenopus laevis GN=zic4 PE=2 SV=1 GO:0005622: intracellular: Cellular Component; O:0008270: zinc ion binding: Molecular Function high 9.65 38.4 24.8 52.0 8.6 0.4 1.1 0.2 0.4 13.2 CGI_10023321 IPR000326: Phosphatidic acid phosphatase type 2/haloperoxidase SGPP2_HUMAN Sphingosine-1-phosphate phosphatase 2 OS=Homo sapiens GN=SGPP2 PE=2 SV=1 GO:0003824: catalytic activity: Molecular Function; O:0016020: membrane: Cellular Component high 9.65 30.5 26.8 34.2 3.5 1.8 5.6 0.2 2.3 5.6 CGI_10028495 "IPR001148: Carbonic anhydrase, alpha-class, catalytic domain" CAH6_SHEEP Carbonic anhydrase 6 OS=Ovis aries GN=CA6 PE=1 SV=1 high 9.48 17.9 14.5 21.4 3.8 1.8 4.3 0.4 0.6 0.5 CGI_10004734 IPR006015: Universal stress protein A; PR006016: UspA Y1388_SYNY3 Uncharacterized protein sll1388 OS=Synechocystis sp. (strain PCC 6803) GN=sll1388 PE=3 SV=1 GO:0006950: response to stress: Biological Process high 9.43 9.8 8.7 10.9 1.6 0.3 4.2 0.1 0.0 0.0 CGI_10023163 "IPR000742: Epidermal growth factor-like, type 3; PR006210: Epidermal growth factor-like" GO:0005515: protein binding: Molecular Function high 9.36 17.3 13.5 21.0 2.5 0.8 0.5 4.7 0.1 2.5 CGI_10012534 "IPR000276: 7TM GPCR, rhodopsin-like; PR001817: Vasopressin receptor; PR017452: GPCR, rhodopsin-like superfamily" ANR_EISFO Annetocin receptor OS=Eisenia foetida GN=anr PE=2 SV=1 GO:0005000: vasopressin receptor activity: Molecular Function; O:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 9.36 19.6 24.6 14.6 3.5 2.0 2.4 0.8 0.3 3.5 CGI_10023400 "IPR000323: Copper type II, ascorbate-dependent monooxygenase, N-terminal; PR008977: PHM/PNGase F-fold domain" TEMPT_APLCA Temptin OS=Aplysia californica PE=1 SV=1 GO:0003824: catalytic activity: Molecular Function; O:0004497: monooxygenase activity: Molecular Function; O:0005507: copper ion binding: Molecular Function; O:0009987: cellular process: Biological Process high 9.32 15.8 13.7 18.0 0.8 0.3 1.0 0.3 7.6 0.2 CGI_10024091 "IPR001356: Homeobox; PR009057: Homeodomain-like; PR017995: Homeobox protein, antennapedia type; PR020479: Homeobox, eukaryotic" HXB4A_DANRE Homeobox protein Hox-B4a OS=Danio rerio GN=hoxb4a PE=2 SV=3 "GO:0003677: DNA binding: Molecular Function; O:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005634: nucleus: Cellular Component; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 9.23 32.0 38.4 25.5 7.0 6.3 5.7 1.1 0.5 0.2 CGI_10026463 "IPR001024: Lipoxygenase, LH2; PR008976: Lipase/lipooxygenase, PLAT/LH2" LOXH1_HUMAN Lipoxygenase homology domain-containing protein 1 OS=Homo sapiens GN=LOXHD1 PE=1 SV=2 GO:0005515: protein binding: Molecular Function high 9.22 11.4 9.2 13.5 0.2 0.0 7.2 0.0 0.0 0.0 CGI_10008760 high 9.17 21.3 21.2 21.5 2.1 6.1 0.6 0.0 0.2 5.0 CGI_10004909 IPR000436: Sushi/SCR/CCP; PR016060: Complement control module high 9.14 18.0 17.0 18.9 2.6 1.1 6.7 0.4 0.8 0.2 CGI_10008594 IPR000175: Sodium:neurotransmitter symporter S6A13_BOVIN Sodium- and chloride-dependent GABA transporter 2 OS=Bos taurus GN=SLC6A13 PE=2 SV=1 GO:0005328: neurotransmitter:sodium symporter activity: Molecular Function; O:0005887: integral to plasma membrane: Cellular Component; O:0006836: neurotransmitter transport: Biological Process; O:0016020: membrane: Cellular Component high 9.13 6.6 2.0 11.3 0.9 0.3 0.3 0.1 1.5 1.2 CGI_10005311 IPR001507: Endoglin/CD105 antigen high 9.12 34.2 28.8 39.7 2.5 1.6 4.5 0.2 0.0 13.7 CGI_10002429 high 9.11 20.5 22.8 18.2 3.7 6.7 1.9 0.2 0.1 0.9 CGI_10003466 high 8.89 8.0 5.9 10.1 0.9 0.7 1.3 1.0 0.0 1.4 CGI_10018472 high 8.80 56.8 40.5 73.2 13.5 20.4 2.0 0.8 0.5 1.6 CGI_10017891 "IPR000276: 7TM GPCR, rhodopsin-like; PR000611: Neuropeptide Y receptor; PR017452: GPCR, rhodopsin-like superfamily" GPR83_MOUSE Probable G-protein coupled receptor 83 OS=Mus musculus GN=Gpr83 PE=2 SV=2 GO:0004983: neuropeptide Y receptor activity: Molecular Function; O:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 8.76 6.5 6.7 6.3 0.3 1.3 2.3 0.1 0.0 0.5 CGI_10010329 IPR011046: WD40 repeat-like-containing domain; PR017986: WD40-repeat-containing domain GO:0005515: protein binding: Molecular Function high 8.72 8.6 6.1 11.2 1.3 1.1 0.9 0.1 2.1 0.5 CGI_10013239 ZAN_MOUSE Zonadhesin OS=Mus musculus GN=Zan PE=2 SV=1 high 8.70 18.4 14.9 21.9 4.6 1.9 3.4 0.5 1.3 1.1 CGI_10026948 "IPR000276: 7TM GPCR, rhodopsin-like; PR000611: Neuropeptide Y receptor; PR017452: GPCR, rhodopsin-like superfamily" OX1R_RAT Orexin receptor type 1 OS=Rattus norvegicus GN=Hcrtr1 PE=2 SV=1 GO:0004983: neuropeptide Y receptor activity: Molecular Function; O:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 8.51 6.9 6.1 7.6 0.9 1.3 1.4 0.1 0.0 1.2 CGI_10019858 high 8.39 13.3 10.9 15.8 1.3 2.8 0.9 0.1 0.0 4.5 CGI_10024087 Homeobox_protein_4_Gibbula_varia_ACX84672.1 "IPR001356: Homeobox; PR009057: Homeodomain-like; PR020479: Homeobox, eukaryotic" HOX3_BRAFL Homeobox protein HOX3 OS=Branchiostoma floridae PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0043565: sequence-specific DNA binding: Molecular Function" high 8.28 17.5 24.7 10.3 2.3 0.9 8.9 0.1 0.0 0.5 CGI_10023999 IPR001828: Extracellular ligand-binding receptor ANPRA_HUMAN Atrial natriuretic peptide receptor A OS=Homo sapiens GN=NPR1 PE=2 SV=1 high 8.25 19.8 21.3 18.4 2.1 1.8 7.6 0.2 0.2 2.6 CGI_10021716 high 8.23 44.0 42.2 45.9 4.3 5.3 6.1 10.0 0.0 6.4 CGI_10005120 "IPR001258: NHL repeat; PR013017: NHL repeat, subgroup" TRIM2_HUMAN Tripartite motif-containing protein 2 OS=Homo sapiens GN=TRIM2 PE=1 SV=1 GO:0005515: protein binding: Molecular Function high 8.18 14.4 11.5 17.3 1.3 0.9 0.5 4.1 3.3 0.4 CGI_10008400 "IPR000742: Epidermal growth factor-like, type 3" GO:0005515: protein binding: Molecular Function high 7.98 5.9 2.6 9.2 1.5 1.5 0.3 0.2 0.8 0.1 CGI_10005344 "IPR000033: LDLR class B repeat; PR000742: Epidermal growth factor-like, type 3; PR001881: EGF-like calcium-binding; PR002172: LDLR class A repeat; PR006210: Epidermal growth factor-like; PR009030: Growth factor, receptor" LRP1_HUMAN Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens GN=LRP1 PE=1 SV=1 GO:0005509: calcium ion binding: Molecular Function; O:0005515: protein binding: Molecular Function; O:0016020: membrane: Cellular Component high 7.95 29.3 24.7 33.8 4.3 7.2 3.0 0.9 5.1 1.6 CGI_10027669 high 7.80 6.4 5.1 7.7 0.9 0.0 0.8 0.0 1.1 2.2 CGI_10007173 "IPR000436: Sushi/SCR/CCP; PR000742: Epidermal growth factor-like, type 3; PR000884: Thrombospondin, type 1 repeat; PR001881: EGF-like calcium-binding; PR003410: Hyalin; PR006209: EGF; PR006210: Epidermal growth factor-like; PR009030: Growth factor, receptor; PR011641: Tyrosine-protein kinase ephrin type A/B receptor-like; PR016060: Complement control module" "SVEP1_HUMAN Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens GN=SVEP1 PE=1 SV=2" GO:0005509: calcium ion binding: Molecular Function; O:0005515: protein binding: Molecular Function high 7.69 13.9 15.3 12.4 0.6 0.2 3.5 0.6 0.3 5.7 CGI_10013409 "IPR017452: GPCR, rhodopsin-like superfamily; PR019427: 7TM GPCR, serpentine receptor class w, Srw" high 7.66 7.7 7.4 8.0 0.8 3.4 0.2 0.7 0.0 1.0 CGI_10012136 "IPR001258: NHL repeat; PR013017: NHL repeat, subgroup" TRIM2_HUMAN Tripartite motif-containing protein 2 OS=Homo sapiens GN=TRIM2 PE=1 SV=1 GO:0005515: protein binding: Molecular Function high 7.59 11.0 8.9 13.1 1.3 1.6 0.6 2.7 2.2 0.3 CGI_10008602 "IPR001926: Pyridoxal phosphate-dependent enzyme, beta subunit" SDSL_MOUSE Serine dehydratase-like OS=Mus musculus GN=Sdsl PE=2 SV=1 GO:0003824: catalytic activity: Molecular Function; O:0008152: metabolic process: Biological Process; O:0030170: pyridoxal phosphate binding: Molecular Function high 7.57 19.4 15.0 23.8 1.8 3.7 3.3 3.3 0.7 2.7 CGI_10020232 "IPR002035: von Willebrand factor, type A" CO6A6_MOUSE Collagen alpha-6(VI) chain OS=Mus musculus GN=Col6a6 PE=1 SV=2 GO:0005515: protein binding: Molecular Function high 7.50 33.2 30.0 36.3 2.3 2.2 14.7 2.2 0.4 4.7 CGI_10025998 IPR006029: Neurotransmitter-gated ion-channel transmembrane domain; PR006201: Neurotransmitter-gated ion-channel; PR006202: Neurotransmitter-gated ion-channel ligand-binding ACHA3_CHICK Neuronal acetylcholine receptor subunit alpha-3 OS=Gallus gallus GN=CHRNA3 PE=2 SV=2 GO:0005230: extracellular ligand-gated ion channel activity: Molecular Function; O:0006810: transport: Biological Process; O:0006811: ion transport: Biological Process; O:0016020: membrane: Cellular Component; O:0016021: integral to membrane: Cellular Component high 7.50 12.2 8.4 16.0 1.7 3.2 2.7 0.3 0.4 1.6 CGI_10021541 high 7.50 9.2 8.1 10.2 0.5 1.5 0.8 0.2 4.3 0.1 CGI_10018675 "IPR000742: Epidermal growth factor-like, type 3; PR000884: Thrombospondin, type 1 repeat; PR001846: von Willebrand factor, type D domain; PR001881: EGF-like calcium-binding; PR003886: Nidogen, extracellular domain; PR006210: Epidermal growth factor-like; PR009030: Growth factor, receptor; PR013091: EGF calcium-binding; PR015919: Cadherin-like" FBN3_HUMAN Fibrillin-3 OS=Homo sapiens GN=FBN3 PE=2 SV=2 GO:0005509: calcium ion binding: Molecular Function; O:0005515: protein binding: Molecular Function; O:0007160: cell-matrix adhesion: Biological Process; O:0016020: membrane: Cellular Component high 7.48 10.5 6.5 14.5 0.8 0.4 4.5 0.1 0.3 2.3 CGI_10011058 high 7.47 5.7 6.9 4.6 0.7 2.8 0.7 0.2 0.2 0.1 CGI_10023500 "IPR000276: 7TM GPCR, rhodopsin-like; PR017452: GPCR, rhodopsin-like superfamily" GPR54_ORENI G-protein coupled receptor 54 OS=Oreochromis niloticus GN=gpr54 PE=2 SV=1 GO:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 7.39 8.2 5.0 11.5 0.6 0.6 1.2 0.1 0.0 4.1 CGI_10016017 IPR002557: Chitin binding domain; PR002575: Aminoglycoside phosphotransferase; PR006869: Domain of unknown function DUF547; PR008985: Concanavalin A-like lectin/glucanase; PR011009: Protein kinase-like domain GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function high 7.38 47.4 44.9 49.9 11.1 4.7 5.3 2.7 10.4 4.3 CGI_10011787 high 7.28 17.8 14.6 21.1 8.1 2.1 0.8 3.2 0.0 0.5 CGI_10005421 "IPR000157: Toll-Interleukin receptor; PR000483: Cysteine-rich flanking region, C-terminal domain; PR001611: Leucine-rich repeat; PR003591: Leucine-rich repeat, typical subtype; PR004075: Interleukin-1 receptor, type I/Toll precursor; PR008197: Whey acidic protein, 4-disulphide core" TOLL_DROME Protein toll OS=Drosophila melanogaster GN=Tl PE=1 SV=1 GO:0004888: transmembrane receptor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0005576: extracellular region: Cellular Component; O:0007165: signal transduction: Biological Process; O:0030414: peptidase inhibitor activity: Molecular Function; O:0031224: intrinsic to membrane: Cellular Component; O:0045087: innate immune response: Biological Process high 7.26 20.2 16.5 23.9 1.0 0.8 6.9 0.3 0.0 7.8 CGI_10019993 IPR002557: Chitin binding domain GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function high 7.25 13.7 12.7 14.8 8.5 1.2 0.9 0.5 0.1 0.3 CGI_10022283 "IPR000315: Zinc finger, B-box; PR001841: Zinc finger, RING-type; PR018957: Zinc finger, C3HC4 RING-type" TRI45_HUMAN Tripartite motif-containing protein 45 OS=Homo sapiens GN=TRIM45 PE=1 SV=2 GO:0005515: protein binding: Molecular Function; O:0005622: intracellular: Cellular Component; O:0008270: zinc ion binding: Molecular Function high 7.20 8.6 5.0 12.1 1.5 0.7 1.1 0.8 1.5 1.6 CGI_10006117 high 7.15 302.5 321.9 283.1 49.6 27.4 76.6 48.4 14.9 37.1 CGI_10005733 high 7.15 13.5 11.0 15.9 1.2 1.0 0.4 0.1 8.4 0.3 CGI_10027820 high 7.10 13.9 10.8 17.0 2.2 1.3 3.5 0.2 2.4 2.3 CGI_10001123 "IPR001680: WD40 repeat; PR002007: Haem peroxidase, animal; PR010255: Haem peroxidase; PR011046: WD40 repeat-like-containing domain; PR017986: WD40-repeat-containing domain; PR019781: WD40 repeat, subgroup; PR019782: WD40 repeat 2; PR019791: Haem peroxidase, animal, subgroup" PERC_DROME Chorion peroxidase OS=Drosophila melanogaster GN=pxt PE=2 SV=3 GO:0004601: peroxidase activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006979: response to oxidative stress: Biological Process; O:0020037: heme binding: Molecular Function; O:0055114: oxidation-reduction process: Biological Process high 6.95 16.1 10.5 21.7 3.2 2.4 1.8 2.1 1.9 2.5 CGI_10007411 high 6.88 36.0 29.4 42.7 4.4 19.8 1.9 1.4 2.6 1.4 CGI_10019992 IPR002557: Chitin binding domain GO:0005576: extracellular region: Cellular Component; O:0006030: chitin metabolic process: Biological Process; O:0008061: chitin binding: Molecular Function high 6.87 45.0 41.6 48.5 31.2 3.6 2.6 1.3 0.1 0.6 CGI_10013492 "IPR000742: Epidermal growth factor-like, type 3" TCB2_CAEBR Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 GO:0005515: protein binding: Molecular Function high 6.85 10.0 6.4 13.5 0.5 1.0 0.7 5.1 0.3 1.2 CGI_10017650 IPR001092: Helix-loop-helix DNA-binding domain; PR011598: Helix-loop-helix DNA-binding ASCL1_XENLA Achaete-scute homolog 1 OS=Xenopus laevis GN=ascl1 PE=2 SV=1 GO:0005634: nucleus: Cellular Component; O:0030528: transcription regulator activity: Molecular Function; O:0045449: regulation of transcription: Biological Process high 6.83 13.4 15.5 11.3 0.2 1.8 3.2 0.2 0.2 6.3 CGI_10007177 IPR011641: Tyrosine-protein kinase ephrin type A/B receptor-like "SVEP1_HUMAN Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens GN=SVEP1 PE=1 SV=2" high 6.81 5.3 7.1 3.6 0.0 0.6 0.7 0.5 0.0 3.0 CGI_10027588 high 6.74 132.0 100.4 163.5 27.0 21.5 10.1 1.8 0.4 56.6 CGI_10024484 high 6.72 25.0 23.9 26.1 4.1 7.9 9.5 0.5 0.2 0.2 CGI_10010344 HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase OS=Homo sapiens GN=HGSNAT PE=1 SV=2 high 6.65 20.0 18.5 21.5 6.9 5.2 4.7 0.3 0.1 0.8 CGI_10002476 high 6.63 13.1 15.7 10.5 5.8 1.8 0.4 1.5 0.8 1.7 CGI_10002661 IPR003402: Protein of unknown function Met10 TRMT5_HUMAN tRNA (guanine-N(1)-)-methyltransferase OS=Homo sapiens GN=TRMT5 PE=1 SV=2 high 6.63 22.3 18.8 25.7 3.8 6.5 2.6 1.9 3.9 1.6 CGI_10013332 IPR002110: Ankyrin repeat; PR020683: Ankyrin repeat-containing domain ANR50_HUMAN Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 GO:0005515: protein binding: Molecular Function high 6.57 38.9 33.5 44.3 11.0 22.0 0.0 2.3 0.3 0.0 CGI_10025575 IPR006202: Neurotransmitter-gated ion-channel ligand-binding ACH10_CHICK Neuronal acetylcholine receptor subunit alpha-10 OS=Gallus gallus GN=CHRNA10 PE=3 SV=1 GO:0005230: extracellular ligand-gated ion channel activity: Molecular Function; O:0006810: transport: Biological Process; O:0016020: membrane: Cellular Component high 6.52 30.6 25.9 35.3 6.8 4.8 3.3 8.8 0.1 4.4 CGI_10027587 high 6.51 23.4 17.9 29.0 4.5 2.7 2.0 0.2 0.0 12.2 CGI_10000168 high 6.51 148.8 115.2 182.5 31.8 24.7 10.8 1.9 0.4 67.5 CGI_10025197 "IPR000276: 7TM GPCR, rhodopsin-like; PR000611: Neuropeptide Y receptor; PR017452: GPCR, rhodopsin-like superfamily" NPFF2_MOUSE Neuropeptide FF receptor 2 OS=Mus musculus GN=Npffr2 PE=2 SV=2 GO:0004983: neuropeptide Y receptor activity: Molecular Function; O:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 6.44 28.9 31.5 26.4 7.1 3.2 9.0 1.0 2.3 4.5 CGI_10013419 CaM_aragonite_Pinctada_fucata_AAQ20043.1 "IPR002048: Calcium-binding EF-hand; PR018249: EF-HAND 2; PR019577: SPARC/Testican, calcium-binding domain" CALL_CAEEL Calmodulin-like protein OS=Caenorhabditis elegans GN=cal-1 PE=2 SV=1 GO:0005509: calcium ion binding: Molecular Function; O:0005578: proteinaceous extracellular matrix: Cellular Component; O:0007165: signal transduction: Biological Process high 6.39 370.3 334.9 405.7 45.1 38.3 172.8 14.0 62.9 14.3 CGI_10008035 "IPR002466: Adenosine deaminase/editase; PR013521: Potassium channel, inwardly rectifying, Kir, conserved region 2; PR014756: Immunoglobulin E-set" IRK12_MOUSE ATP-sensitive inward rectifier potassium channel 12 OS=Mus musculus GN=Kcnj12 PE=2 SV=1 GO:0003723: RNA binding: Molecular Function; O:0004000: adenosine deaminase activity: Molecular Function; O:0006396: RNA processing: Biological Process high 6.34 5.9 4.3 7.5 1.1 2.7 0.1 0.2 1.4 0.2 CGI_10024092 high 6.23 23.3 28.3 18.2 2.7 5.4 10.7 0.3 3.4 0.0 CGI_10012215 IPR000182: GCN5-related N-acetyltransferase (GNAT) domain; PR016181: Acyl-CoA N-acyltransferase GO:0008080: N-acetyltransferase activity: Molecular Function; O:0008152: metabolic process: Biological Process high 6.20 64.5 64.1 64.9 16.3 37.2 3.9 0.5 1.9 2.7 CGI_10028171 "IPR001356: Homeobox; PR001781: Zinc finger, LIM-type; PR009057: Homeodomain-like" LHX3_DANRE LIM/homeobox protein Lhx3 OS=Danio rerio GN=lhx3 PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0008270: zinc ion binding: Molecular Function; O:0043565: sequence-specific DNA binding: Molecular Function" high 6.11 5.7 5.0 6.3 0.6 0.5 3.1 0.3 0.0 1.1 CGI_10020955 IPR004031: PMP-22/EMP/MP20/Claudin EMP2_HUMAN Epithelial membrane protein 2 OS=Homo sapiens GN=EMP2 PE=2 SV=1 GO:0016020: membrane: Cellular Component high 6.11 5.2 3.2 7.2 0.3 0.3 1.0 0.1 0.0 3.4 CGI_10023620 "IPR000276: 7TM GPCR, rhodopsin-like; PR017452: GPCR, rhodopsin-like superfamily" NMUR2_RAT Neuromedin-U receptor 2 OS=Rattus norvegicus GN=Nmur2 PE=1 SV=2 GO:0007186: G-protein coupled receptor protein signaling pathway: Biological Process; O:0016021: integral to membrane: Cellular Component high 6.09 6.2 4.5 7.9 1.3 1.1 1.1 1.1 0.6 1.0 CGI_10025817 "IPR001148: Carbonic anhydrase, alpha-class, catalytic domain" CAH1_CHIHA Carbonic anhydrase 1 OS=Chionodraco hamatus GN=ca1 PE=1 SV=1 high 6.04 17.6 12.5 22.7 2.2 1.9 11.9 0.5 0.5 0.5 CGI_10020740 high 6.02 32.5 34.8 30.3 4.8 1.9 16.6 1.0 1.4 6.8 CGI_10028355 "IPR001356: Homeobox; PR001781: Zinc finger, LIM-type; PR009057: Homeodomain-like" ISL1_RAT Insulin gene enhancer protein ISL-1 OS=Rattus norvegicus GN=Isl1 PE=2 SV=1 "GO:0003700: sequence-specific DNA binding transcription factor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0006355: regulation of transcription, DNA-dependent: Biological Process; O:0008270: zinc ion binding: Molecular Function; O:0043565: sequence-specific DNA binding: Molecular Function" high 6.02 23.1 15.2 31.1 5.8 0.6 6.7 0.3 0.8 8.9 CGI_10019861 "IPR005084: Carbohydrate binding domain, family 6; PR008979: Galactose-binding domain-like" GO:0030246: carbohydrate binding: Molecular Function high 5.91 12.6 8.7 16.6 5.8 5.0 1.5 0.3 0.0 0.3 CGI_10002256 "IPR001752: Kinesin, motor domain" KIF1B_HUMAN Kinesin-like protein KIF1B OS=Homo sapiens GN=KIF1B PE=1 SV=5 GO:0003777: microtubule motor activity: Molecular Function; O:0005524: ATP binding: Molecular Function; O:0007018: microtubule-based movement: Biological Process high 5.83 5.3 5.7 4.8 0.2 0.3 2.7 0.1 0.0 2.2 CGI_10003134 "IPR000157: Toll-Interleukin receptor; PR000742: Epidermal growth factor-like, type 3; PR004075: Interleukin-1 receptor, type I/Toll precursor; PR006210: Epidermal growth factor-like" TOLL_DROME Protein toll OS=Drosophila melanogaster GN=Tl PE=1 SV=1 GO:0004888: transmembrane receptor activity: Molecular Function; O:0005515: protein binding: Molecular Function; O:0007165: signal transduction: Biological Process; O:0031224: intrinsic to membrane: Cellular Component; O:0045087: innate immune response: Biological Process high 5.83 13.6 12.2 15.1 1.5 0.3 0.9 0.6 9.9 0.9 CGI_10019610 high 5.83 11.8 7.4 16.1 1.3 0.9 4.9 0.3 0.0 4.7 CGI_10011206 high 5.82 6.5 6.1 7.0 0.9 0.6 4.5 0.1 0.1 0.6 CGI_10012599 high 5.75 6.0 5.1 6.9 1.3 3.0 0.0 0.2 1.7 0.1 CGI_10026728 IPR000863: Sulfotransferase domain CHST1_HUMAN Carbohydrate sulfotransferase 1 OS=Homo sapiens GN=CHST1 PE=1 SV=1 GO:0008146: sulfotransferase activity: Molecular Function high 5.70 7.9 7.0 8.8 1.9 1.1 0.7 2.5 1.4 0.8 CGI_10022482 IPR001283: Allergen V5/Tpx-1-related; PR014044: CAP domain PI16_MOUSE Peptidase inhibitor 16 OS=Mus musculus GN=Pi16 PE=2 SV=1 GO:0005576: extracellular region: Cellular Component high 5.66 12.0 10.6 13.4 4.2 1.8 1.0 0.1 0.2 5.4 CGI_10015495 IPR000033: LDLR class B repeat; PR000436: Sushi/SCR/CCP; PR006210: Epidermal growth factor-like LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 OS=Homo sapiens GN=LRP6 PE=1 SV=1 GO:0005515: protein binding: Molecular Function; O:0016020: membrane: Cellular Component high 5.65 5.3 4.9 5.7 0.7 0.7 0.8 1.6 0.7 1.0 CGI_10008479 IPR003689: Zinc/iron permease S39AC_MOUSE Zinc transporter ZIP12 OS=Mus musculus GN=Slc39a12 PE=2 SV=1 GO:0016020: membrane: Cellular Component; O:0030001: metal ion transport: Biological Process; O:0046873: metal ion transmembrane transporter activity: Molecular Function; O:0055085: transmembrane transport: Biological Process high 5.64 25.1 19.6 30.5 2.8 22.8 0.5 0.6 0.0 0.1 CGI_10009270 PFMG4_Pinctada_fucata_AAZ76258.1 IPR001073: Complement C1q protein; PR008983: Tumour necrosis factor-like MMRN2_HUMAN Multimerin-2 OS=Homo sapiens GN=MMRN2 PE=1 SV=1 GO:0005515: protein binding: Molecular Function high 5.59 33.3 28.4 38.3 9.2 0.5 4.8 5.0 1.8 14.5 CGI_10006039 "IPR003137: Protease-associated domain, PA; PR007365: Transferrin receptor-like, dimerisation; PR007484: Peptidase M28" NALD2_HUMAN N-acetylated-alpha-linked acidic dipeptidase 2 OS=Homo sapiens GN=NAALAD2 PE=1 SV=1 GO:0006508: proteolysis: Biological Process; O:0008233: peptidase activity: Molecular Function high 5.50 8.6 6.8 10.3 0.8 0.7 0.4 7.3 0.2 0.0 CGI_10019061 IPR006202: Neurotransmitter-gated ion-channel ligand-binding ACHA5_RAT Neuronal acetylcholine receptor subunit alpha-5 OS=Rattus norvegicus GN=Chrna5 PE=2 SV=1 GO:0005230: extracellular ligand-gated ion channel activity: Molecular Function; O:0006810: transport: Biological Process; O:0016020: membrane: Cellular Component high 5.48 21.0 31.8 10.3 1.7 3.5 10.1 0.5 0.2 7.1 CGI_10001623 high 5.48 37.5 24.1 50.8 30.5 0.4 1.9 0.2 5.2 2.8 CGI_10013060 "IPR012314: Peptidase M12B, GON-ADAMTSs" GO:0004222: metalloendopeptidase activity: Molecular Function; O:0005578: proteinaceous extracellular matrix: Cellular Component; O:0008270: zinc ion binding: Molecular Function high 5.48 35.9 30.9 40.8 4.6 24.8 8.0 1.1 0.3 0.4 CGI_10027334 IPR000643: Iodothyronine deiodinase IOD3_RANCA Type III iodothyronine deiodinase OS=Rana catesbeiana GN=dio3 PE=2 SV=2 GO:0004800: thyroxine 5'-deiodinase activity: Molecular Function; O:0055114: oxidation-reduction process: Biological Process high 5.43 6.2 7.1 5.4 0.9 2.1 0.3 0.0 0.4 3.1 CGI_10027310 high 5.37 25.5 26.5 24.5 7.1 0.6 6.4 0.4 1.1 12.9 CGI_10015951 IPR002048: Calcium-binding EF-hand; PR018248: EF-hand; PR018249: EF-HAND 2 CAYP1_RABIT Calcyphosin OS=Oryctolagus cuniculus GN=CAPS PE=1 SV=1 GO:0005509: calcium ion binding: Molecular Function high 5.37 8.8 9.2 8.4 0.7 0.8 2.4 0.0 0.0 6.0 CGI_10021549 high 5.37 11.6 10.3 13.0 1.6 1.4 3.0 0.5 5.7 0.9 CGI_10028415 SAMH1_DANRE SAM domain and HD domain-containing protein 1 OS=Danio rerio GN=samhd1 PE=2 SV=2 high 5.35 23.7 19.7 27.8 4.4 3.6 9.8 1.5 1.4 6.0 CGI_10001543 IPR001092: Helix-loop-helix DNA-binding domain; PR011598: Helix-loop-helix DNA-binding OLIG3_HUMAN Oligodendrocyte transcription factor 3 OS=Homo sapiens GN=OLIG3 PE=2 SV=2 GO:0005634: nucleus: Cellular Component; O:0030528: transcription regulator activity: Molecular Function; O:0045449: regulation of transcription: Biological Process high 5.30 6.8 6.3 7.3 0.9 1.4 1.5 0.8 0.7 2.5 CGI_10003759 high 5.29 20.9 22.2 19.6 0.5 1.7 14.3 0.2 0.0 7.0 CGI_10014785 CD033_MOUSE UPF0462 protein C4orf33 homolog OS=Mus musculus GN=D3Ertd751e PE=2 SV=1 high 5.21 33.5 27.3 39.7 37.4 0.4 0.4 0.4 0.0 0.1 CGI_10016570 high 5.10 7.3 9.4 5.1 0.5 0.0 6.1 0.5 0.0 1.4 CGI_10014131 Alkaline phosphatase "IPR001952: Alkaline phosphatase; PR017850: Alkaline-phosphatase-like, core domain" "PPBT_BOVIN Alkaline phosphatase, tissue-nonspecific isozyme OS=Bos taurus GN=ALPL PE=1 SV=2" GO:0003824: catalytic activity: Molecular Function; O:0008152: metabolic process: Biological Process; O:0016791: phosphatase activity: Molecular Function high 5.08 23.8 23.0 24.6 6.7 8.1 4.7 0.5 2.3 5.9 CGI_10013387 high 5.05 20.1 14.7 25.6 6.7 0.4 16.4 0.1 0.1 0.2 CGI_10002706 "IPR003961: Fibronectin, type III; PR008957: Fibronectin type III domain" GO:0005515: protein binding: Molecular Function high 5.01 21.3 19.0 23.7 4.6 6.5 4.8 5.4 0.4 3.9