circ (465,819) 4	/dbget-bin/www_bget?C00165	C00165 (Diacylglycerol)
circ (442,751) 4	/dbget-bin/www_bget?C01245	C01245 (D-myo-Inositol 1,4,5-trisphosphate)
circ (496,751) 4	/dbget-bin/www_bget?C00076	C00076 (Calcium cation)
circ (306,205) 4	/dbget-bin/www_bget?C00575	C00575 (3',5'-Cyclic AMP)
circ (552,300) 4	/dbget-bin/www_bget?C05981	C05981 (Phosphatidylinositol-3,4,5-trisphosphate)
rect (137,325) (183,342)	/dbget-bin/www_bget?hsa:10663+hsa:10803+hsa:1230+hsa:1232+hsa:1233+hsa:1234+hsa:1235+hsa:1236+hsa:1237+hsa:1524+hsa:2826+hsa:2829+hsa:2833+hsa:3577+hsa:3579+hsa:643+hsa:729230+hsa:7852+H00097+D03210+D06297+D06557+D06670+D08971+D09761	10663 (CXCR6), 10803 (CCR9), 1230 (CCR1), 1232 (CCR3), 1233 (CCR4), 1234 (CCR5), 1235 (CCR6), 1236 (CCR7), 1237 (CCR8), 1524 (CX3CR1), 2826 (CCR10), 2829 (XCR1), 2833 (CXCR3), 3577 (CXCR1), 3579 (CXCR2), 643 (CXCR5), 729230 (CCR2), 7852 (CXCR4), H00097 (Chemokine receptor defect, including the following disease:), D03210 (Ancriviroc (USAN/INN)), D06297 (Vicriviroc maleate (USAN)), D06557 (Aplaviroc hydrochloride (USAN)), D06670 (Maraviroc (JAN/INN)), D08971 (Plerixafor (INN/USAN)), D09761 (Mogamulizumab (genetical recombination) (JAN))
rect (70,325) (116,342)	/dbget-bin/www_bget?hsa:10344+hsa:10563+hsa:10850+hsa:2919+hsa:2920+hsa:2921+hsa:3576+hsa:3627+hsa:388372+hsa:414062+hsa:4283+hsa:5196+hsa:5197+hsa:5473+hsa:56477+hsa:58191+hsa:6346+hsa:6347+hsa:6348+hsa:6349+hsa:6351+hsa:6352+hsa:6354+hsa:6355+hsa:6356+hsa:6357+hsa:6358+hsa:6359+hsa:6360+hsa:6361+hsa:6362+hsa:6363+hsa:6364+hsa:6366+hsa:6367+hsa:6368+hsa:6369+hsa:6370+hsa:6372+hsa:6373+hsa:6374+hsa:6375+hsa:6376+hsa:6387+hsa:6846+hsa:9547+hsa:9560	10344 (CCL26), 10563 (CXCL13), 10850 (CCL27), 2919 (CXCL1), 2920 (CXCL2), 2921 (CXCL3), 3576 (IL8), 3627 (CXCL10), 388372 (CCL4L2), 414062 (CCL3L3), 4283 (CXCL9), 5196 (PF4), 5197 (PF4V1), 5473 (PPBP), 56477 (CCL28), 58191 (CXCL16), 6346 (CCL1), 6347 (CCL2), 6348 (CCL3), 6349 (CCL3L1), 6351 (CCL4), 6352 (CCL5), 6354 (CCL7), 6355 (CCL8), 6356 (CCL11), 6357 (CCL13), 6358 (CCL14), 6359 (CCL15), 6360 (CCL16), 6361 (CCL17), 6362 (CCL18), 6363 (CCL19), 6364 (CCL20), 6366 (CCL21), 6367 (CCL22), 6368 (CCL23), 6369 (CCL24), 6370 (CCL25), 6372 (CXCL6), 6373 (CXCL11), 6374 (CXCL5), 6375 (XCL1), 6376 (CX3CL1), 6387 (CXCL12), 6846 (XCL2), 9547 (CXCL14), 9560 (CCL4L1)
rect (282,120) (328,137)	/dbget-bin/www_bget?hsa:3717+hsa:3718+H00012+H00091+D09783	3717 (JAK2), 3718 (JAK3), H00012 (Polycythemia vera), H00091 (T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases:), D09783 (Tofacitinib citrate (JAN))
rect (451,665) (497,682)	/dbget-bin/www_bget?hsa:5747	5747 (PTK2)
rect (332,291) (378,308)	/dbget-bin/www_bget?hsa:2268+hsa:3055+hsa:4067+hsa:6714+D03252+D03658+D06414+D09728	2268 (FGR), 3055 (HCK), 4067 (LYN), 6714 (SRC), D03252 (Bosutinib (USAN)), D03658 (Dasatinib (INN)), D06414 (Dasatinib hydrate (JAN)), D09728 (Bosutinib hydrate (JAN))
rect (623,652) (669,669)	/dbget-bin/www_bget?hsa:5829	5829 (PXN)
rect (734,617) (780,634)	/dbget-bin/www_bget?hsa:387	387 (RHOA)
rect (421,291) (467,308)	/dbget-bin/www_bget?hsa:23533+hsa:5290+hsa:5291+hsa:5293+hsa:5294+hsa:5295+hsa:5296+hsa:8503+H00027	23533 (PIK3R5), 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5294 (PIK3CG), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3), H00027 (Ovarian cancer)
rect (340,743) (386,760)	/dbget-bin/www_bget?hsa:23236+hsa:5330+hsa:5331+hsa:5332	23236 (PLCB1), 5330 (PLCB2), 5331 (PLCB3), 5332 (PLCB4)
rect (421,196) (467,213)	/dbget-bin/www_bget?hsa:25759+hsa:399694+hsa:53358+hsa:6464	25759 (SHC2), 399694 (SHC4), 53358 (SHC3), 6464 (SHC1)
rect (253,291) (299,308)	/dbget-bin/www_bget?hsa:2770+hsa:2771+hsa:2773+H00033	2770 (GNAI1), 2771 (GNAI2), 2773 (GNAI3), H00033 (Adrenal carcinoma)
rect (253,359) (299,376)	/dbget-bin/www_bget?hsa:10681+hsa:2782+hsa:2783+hsa:2784+hsa:2785+hsa:2786+hsa:2787+hsa:2788+hsa:2790+hsa:2791+hsa:2792+hsa:2793+hsa:51764+hsa:54331+hsa:55970+hsa:59345+hsa:94235	10681 (GNB5), 2782 (GNB1), 2783 (GNB2), 2784 (GNB3), 2785 (GNG3), 2786 (GNG4), 2787 (GNG5), 2788 (GNG7), 2790 (GNG10), 2791 (GNG11), 2792 (GNGT1), 2793 (GNGT2), 51764 (GNG13), 54331 (GNG2), 55970 (GNG12), 59345 (GNB4), 94235 (GNG8)
rect (490,196) (536,213)	/dbget-bin/www_bget?hsa:2885	2885 (GRB2)
rect (553,676) (599,693)	/dbget-bin/www_bget?hsa:9564	9564 (BCAR1)
rect (582,441) (628,458)	/dbget-bin/www_bget?hsa:9844	9844 (ELMO1)
rect (623,677) (669,694)	/dbget-bin/www_bget?hsa:1398+hsa:1399	1398 (CRK), 1399 (CRKL)
rect (204,396) (250,413)	/dbget-bin/www_bget?hsa:131890+hsa:156+hsa:157+hsa:2868+hsa:2869+hsa:2870+hsa:6011	131890 (GRK7), 156 (ADRBK1), 157 (ADRBK2), 2868 (GRK4), 2869 (GRK5), 2870 (GRK6), 6011 (GRK1)
rect (188,422) (234,439)	/dbget-bin/www_bget?hsa:408+hsa:409	408 (ARRB1), 409 (ARRB2)
rect (806,617) (852,634)	/dbget-bin/www_bget?hsa:6093+hsa:9475+D01840+D03115+D07941	6093 (ROCK1), 9475 (ROCK2), D01840 (Fasudil hydrochloride (JAN)), D03115 (Fasudil hydrochloride hydrate (JAN)), D07941 (Fasudil (INN))
rect (572,551) (618,568)	/dbget-bin/www_bget?hsa:10451+hsa:7409+hsa:7410	10451 (VAV3), 7409 (VAV1), 7410 (VAV2)
rect (501,551) (547,568)	/dbget-bin/www_bget?hsa:3702	3702 (ITK)
rect (711,551) (757,568)	/dbget-bin/www_bget?hsa:998	998 (CDC42)
rect (268,240) (314,257)	/dbget-bin/www_bget?hsa:107+hsa:108+hsa:109+hsa:111+hsa:112+hsa:113+hsa:114+hsa:115+hsa:196883	107 (ADCY1), 108 (ADCY2), 109 (ADCY3), 111 (ADCY5), 112 (ADCY6), 113 (ADCY7), 114 (ADCY8), 115 (ADCY9), 196883 (ADCY4)
rect (553,743) (599,760)	/dbget-bin/www_bget?hsa:10235	10235 (RASGRP2)
rect (645,743) (691,760)	/dbget-bin/www_bget?hsa:5906+hsa:5908	5906 (RAP1A), 5908 (RAP1B)
rect (799,551) (845,568)	/dbget-bin/www_bget?hsa:7454+hsa:8976+H00100+H00107	7454 (WAS), 8976 (WASL), H00100 (Neutropenic disorders, including the following three diseases:), H00107 (Other well-defined immunodeficiency syndromes, including the following seven diseases:)
rect (553,810) (599,827)	/dbget-bin/www_bget?hsa:5579+hsa:5580+D01066+D08401	5579 (PRKCB), 5580 (PRKCD), D01066 (Polymixin B sulfate (JP16)), D08401 (Polymyxin B (INN))
rect (726,491) (772,508)	/dbget-bin/www_bget?hsa:56288	56288 (PARD3)
rect (726,508) (772,525)	/dbget-bin/www_bget?hsa:5590	5590 (PRKCZ)
rect (726,474) (772,491)	/dbget-bin/www_bget?hsa:26230+hsa:7074	26230 (TIAM2), 7074 (TIAM1)
rect (656,847) (702,864)	/dbget-bin/www_bget?hsa:653361+H00098	653361 (NCF1), H00098 (Chronic granulomatous disease, including the following four diseases:)
rect (327,160) (373,177)	/dbget-bin/www_bget?hsa:5566+hsa:5567+hsa:5568+hsa:5613	5566 (PRKACA), 5567 (PRKACB), 5568 (PRKACG), 5613 (PRKX)
rect (500,611) (546,628)	/dbget-bin/www_bget?hsa:2185	2185 (PTK2B)
rect (845,478) (891,495)	/dbget-bin/www_bget?hsa:5058	5058 (PAK1)
rect (541,120) (587,137)	/dbget-bin/www_bget?hsa:6772+hsa:6773+hsa:6774+hsa:6777+H00016+H00089+H00107	6772 (STAT1), 6773 (STAT2), 6774 (STAT3), 6777 (STAT5B), H00016 (Oral cancer), H00089 (IFN-gamma/IL-12 axis, including the following five diseases:), H00107 (Other well-defined immunodeficiency syndromes, including the following seven diseases:)
rect (835,196) (881,213)	/dbget-bin/www_bget?hsa:5594+hsa:5595	5594 (MAPK1), 5595 (MAPK3)
rect (624,291) (670,308)	/dbget-bin/www_bget?hsa:10000+hsa:207+hsa:208+H00027+H00420	10000 (AKT3), 207 (AKT1), 208 (AKT2), H00027 (Ovarian cancer), H00420 (Familial partial lipodystrophy (FPL), including the following four diseases:)
rect (628,196) (674,213)	/dbget-bin/www_bget?hsa:3265+hsa:3845+hsa:4893+H00003+H00010+H00014+H00016+H00018+H00019+H00020+H00022+H00025+H00026+H00027+H00030+H00032+H00033+H00038+H00040+H00041+H00046+H00047+H00048+H00108	3265 (HRAS), 3845 (KRAS), 4893 (NRAS), H00003 (Acute myeloid leukemia (AML)), H00010 (Multiple myeloma), H00014 (Non-small cell lung cancer), H00016 (Oral cancer), H00018 (Gastric cancer), H00019 (Pancreatic cancer), H00020 (Colorectal cancer), H00022 (Bladder cancer), H00025 (Penile cancer), H00026 (Endometrial Cancer), H00027 (Ovarian cancer), H00030 (Cervical cancer), H00032 (Thyroid cancer), H00033 (Adrenal carcinoma), H00038 (Malignant melanoma), H00040 (Squamous cell carcinoma), H00041 (Kaposi's sarcoma), H00046 (Cholangiocarcinoma), H00047 (Gallbladder cancer), H00048 (Hepatocellular carcinoma), H00108 (Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases:)
rect (766,196) (812,213)	/dbget-bin/www_bget?hsa:5604	5604 (MAP2K1)
rect (697,196) (743,213)	/dbget-bin/www_bget?hsa:5894+hsa:673+H00032+H00038+D06272+D08524	5894 (RAF1), 673 (BRAF), H00032 (Thyroid cancer), H00038 (Malignant melanoma), D06272 (Sorafenib tosilate (JAN)), D08524 (Sorafenib (USAN/INN))
rect (582,424) (628,441)	/dbget-bin/www_bget?hsa:1794	1794 (DOCK2)
rect (744,423) (790,440)	/dbget-bin/www_bget?hsa:5879+hsa:5880+H00099	5879 (RAC1), 5880 (RAC2), H00099 (Leukocyte adhesion deficiency (LAD), including the following four diseases:)
rect (675,238) (721,255)	/dbget-bin/www_bget?hsa:5590	5590 (PRKCZ)
rect (835,290) (881,307)	/dbget-bin/www_bget?hsa:4790+hsa:5970	4790 (NFKB1), 5970 (RELA)
rect (761,328) (807,345)	/dbget-bin/www_bget?hsa:1147+hsa:3551+hsa:8517+H00095	1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG), H00095 (Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases:)
rect (835,327) (881,344)	/dbget-bin/www_bget?hsa:4792+hsa:4793+H00007+H00095	4792 (NFKBIA), 4793 (NFKBIB), H00007 (Hodgkin lymphoma), H00095 (Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases:)
rect (582,377) (628,394)	/dbget-bin/www_bget?hsa:57580	57580 (PREX1)
rect (559,196) (605,213)	/dbget-bin/www_bget?hsa:6654+hsa:6655	6654 (SOS1), 6655 (SOS2)
rect (835,252) (881,269)	/dbget-bin/www_bget?hsa:2309	2309 (FOXO3)
rect (719,363) (765,380)	/dbget-bin/www_bget?hsa:2931+hsa:2932	2931 (GSK3A), 2932 (GSK3B)
rect (932,469) (1033,503)	/kegg-bin/show_pathway?hsadd04810	hsadd04810: Regulation of actin cytoskeleton
rect (32,275) (177,309)	/kegg-bin/show_pathway?hsadd04060	hsadd04060: Cytokine-cytokine receptor interaction
rect (1049,469) (1189,503)	/kegg-bin/show_pathway?hsadd04670	hsadd04670: Leukocyte transendothelial migration
rect (423,83) (532,117)	/kegg-bin/show_pathway?hsadd04630	hsadd04630: Jak-STAT signaling pathway
rect (809,377) (911,411)	/kegg-bin/show_pathway?hsadd04120	hsadd04120: Ubiquitin mediated proteolysis
rect (643,149) (744,183)	/kegg-bin/show_pathway?hsadd04010	hsadd04010: MAPK signaling pathway
rect (40,45) (320,70)	/dbget-bin/www_bget?hsa04062	hsadd04062: Chemokine signaling pathway