circ (604,427) 4 /dbget-bin/www_bget?C05981 C05981 (Phosphatidylinositol-3,4,5-trisphosphate) circ (645,210) 4 /dbget-bin/www_bget?C04637 C04637 (1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate) rect (169,248) (215,265) /dbget-bin/www_bget?hsa:3688+hsa:3690+hsa:3691+hsa:3693+hsa:3694+hsa:3695+hsa:3696+H00083+H00226 3688 (ITGB1), 3690 (ITGB3), 3691 (ITGB4), 3693 (ITGB5), 3694 (ITGB6), 3695 (ITGB7), 3696 (ITGB8), H00083 (Allograft rejection), H00226 (Glanzmann thrombasthenia) rect (169,231) (215,248) /dbget-bin/www_bget?hsa:22801+hsa:3655+hsa:3672+hsa:3673+hsa:3674+hsa:3675+hsa:3676+hsa:3678+hsa:3679+hsa:3680+hsa:3685+hsa:8515+hsa:8516+H00226+D01029+D02778+D06888+D08607 22801 (ITGA11), 3655 (ITGA6), 3672 (ITGA1), 3673 (ITGA2), 3674 (ITGA2B), 3675 (ITGA3), 3676 (ITGA4), 3678 (ITGA5), 3679 (ITGA7), 3680 (ITGA9), 3685 (ITGAV), 8515 (ITGA10), 8516 (ITGA8), H00226 (Glanzmann thrombasthenia), D01029 (Tirofiban hydrochloride (USAN)), D02778 (Abciximab (genetical recombination) (JAN)), D06888 (Eptifibatide (INN)), D08607 (Tirofiban (INN)) rect (423,230) (469,247) /dbget-bin/www_bget?hsa:2316+hsa:2317+hsa:2318 2316 (FLNA), 2317 (FLNB), 2318 (FLNC) rect (724,357) (770,374) /dbget-bin/www_bget?hsa:998 998 (CDC42) rect (794,191) (840,208) /dbget-bin/www_bget?hsa:4638+hsa:85366+hsa:91807 4638 (MYLK), 85366 (MYLK2), 91807 (MYLK3) rect (862,138) (908,155) /dbget-bin/www_bget?hsa:103910+hsa:10398+hsa:10627+hsa:29895+hsa:4633+hsa:4636+hsa:58498+hsa:93408+H00292 103910 (MYL12B), 10398 (MYL9), 10627 (MYL12A), 29895 (MYLPF), 4633 (MYL2), 4636 (MYL5), 58498 (MYL7), 93408 (MYL10), H00292 (Hypertrophic cardiomyopathy (HCM)) rect (867,90) (913,107) /dbget-bin/www_bget?hsa:1729 1729 (DIAPH1) rect (733,165) (779,182) /dbget-bin/www_bget?hsa:4659+hsa:5499+hsa:5500+hsa:5501 4659 (PPP1R12A), 5499 (PPP1CA), 5500 (PPP1CB), 5501 (PPP1CC) rect (676,138) (722,155) /dbget-bin/www_bget?hsa:6093+hsa:9475+D01840+D03115+D07941 6093 (ROCK1), 9475 (ROCK2), D01840 (Fasudil hydrochloride (JAN)), D03115 (Fasudil hydrochloride hydrate (JAN)), D07941 (Fasudil (INN)) rect (694,319) (740,336) /dbget-bin/www_bget?hsa:10000+hsa:207+hsa:208+H00027+H00420 10000 (AKT3), 207 (AKT1), 208 (AKT2), H00027 (Ovarian cancer), H00420 (Familial partial lipodystrophy (FPL), including the following four diseases:) rect (609,277) (655,294) /dbget-bin/www_bget?hsa:5170 5170 (PDPK1) rect (524,257) (570,274) /dbget-bin/www_bget?hsa:29780+hsa:55742+hsa:64098 29780 (PARVB), 55742 (PARVA), 64098 (PARVG) rect (524,319) (570,336) /dbget-bin/www_bget?hsa:3611 3611 (ILK) rect (524,232) (570,249) /dbget-bin/www_bget?hsa:7414 7414 (VCL) rect (524,207) (570,224) /dbget-bin/www_bget?hsa:7408 7408 (VASP) rect (423,369) (469,386) /dbget-bin/www_bget?hsa:5728+H00013+H00024+H00026+H00029+H00031+H00038+H00042+H00048 5728 (PTEN), H00013 (Small cell lung cancer), H00024 (Prostate cancer), H00026 (Endometrial Cancer), H00029 (Vulvar cancer), H00031 (Breast cancer), H00038 (Malignant melanoma), H00042 (Glioma), H00048 (Hepatocellular carcinoma) rect (423,418) (469,435) /dbget-bin/www_bget?hsa:23533+hsa:5290+hsa:5291+hsa:5293+hsa:5294+hsa:5295+hsa:5296+hsa:8503+H00027 23533 (PIK3R5), 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5294 (PIK3CG), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3), H00027 (Ovarian cancer) rect (423,259) (469,276) /dbget-bin/www_bget?hsa:7094+hsa:83660 7094 (TLN1), 83660 (TLN2) rect (524,183) (570,200) /dbget-bin/www_bget?hsa:7791 7791 (ZYX) rect (601,166) (647,183) /dbget-bin/www_bget?hsa:23396 23396 (PIP5K1C) rect (423,204) (469,221) /dbget-bin/www_bget?hsa:81+hsa:87+hsa:88+hsa:89 81 (ACTN4), 87 (ACTN1), 88 (ACTN2), 89 (ACTN3) rect (306,418) (352,435) /dbget-bin/www_bget?hsa:5747 5747 (PTK2) rect (359,319) (405,336) /dbget-bin/www_bget?hsa:824 824 (CAPN2) rect (423,287) (469,304) /dbget-bin/www_bget?hsa:5829 5829 (PXN) rect (304,90) (350,107) /dbget-bin/www_bget?hsa:2909+hsa:394 2909 (GRLF1), 394 (ARHGAP5) rect (217,345) (263,362) /dbget-bin/www_bget?hsa:5578+hsa:5579+hsa:5582+H00063+D01066+D02970+D08401 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG), H00063 (Spinocerebellar ataxia (SCA)), D01066 (Polymixin B sulfate (JP16)), D02970 (Aprinocarsen sodium (USAN)), D08401 (Polymyxin B (INN)) rect (274,295) (320,312) /dbget-bin/www_bget?hsa:6714+D03252+D03658+D06414+D09728 6714 (SRC), D03252 (Bosutinib (USAN)), D03658 (Dasatinib (INN)), D06414 (Dasatinib hydrate (JAN)), D09728 (Bosutinib hydrate (JAN)) rect (223,463) (269,480) /dbget-bin/www_bget?hsa:2534 2534 (FYN) rect (549,138) (595,155) /dbget-bin/www_bget?hsa:387 387 (RHOA) rect (355,138) (401,155) /dbget-bin/www_bget?hsa:5923 5923 (RASGRF1) rect (76,239) (122,256) /dbget-bin/www_bget?hsa:10319+hsa:1101+hsa:1277+hsa:1278+hsa:1280+hsa:1281+hsa:1282+hsa:1284+hsa:1286+hsa:1287+hsa:1288+hsa:1289+hsa:1290+hsa:1291+hsa:1292+hsa:1293+hsa:1301+hsa:1302+hsa:1311+hsa:131873+hsa:22798+hsa:2335+hsa:284217+hsa:3371+hsa:3381+hsa:3908+hsa:3909+hsa:3910+hsa:3911+hsa:3912+hsa:3913+hsa:3914+hsa:3915+hsa:3918+hsa:50509+hsa:5649+hsa:63923+hsa:6696+hsa:7057+hsa:7058+hsa:7059+hsa:7060+hsa:7143+hsa:7148+hsa:7448+hsa:7450+H00219 10319 (LAMC3), 1101 (CHAD), 1277 (COL1A1), 1278 (COL1A2), 1280 (COL2A1), 1281 (COL3A1), 1282 (COL4A1), 1284 (COL4A2), 1286 (COL4A4), 1287 (COL4A5), 1288 (COL4A6), 1289 (COL5A1), 1290 (COL5A2), 1291 (COL6A1), 1292 (COL6A2), 1293 (COL6A3), 1301 (COL11A1), 1302 (COL11A2), 1311 (COMP), 131873 (COL6A6), 22798 (LAMB4), 2335 (FN1), 284217 (LAMA1), 3371 (TNC), 3381 (IBSP), 3908 (LAMA2), 3909 (LAMA3), 3910 (LAMA4), 3911 (LAMA5), 3912 (LAMB1), 3913 (LAMB2), 3914 (LAMB3), 3915 (LAMC1), 3918 (LAMC2), 50509 (COL5A3), 5649 (RELN), 63923 (TNN), 6696 (SPP1), 7057 (THBS1), 7058 (THBS2), 7059 (THBS3), 7060 (THBS4), 7143 (TNR), 7148 (TNXB), 7448 (VTN), 7450 (VWF), H00219 (Hemophilia) rect (169,394) (215,411) /dbget-bin/www_bget?hsa:857+hsa:858+hsa:859+H00419 857 (CAV1), 858 (CAV2), 859 (CAV3), H00419 (Congenital generalized lipodystrophy (CGL)) rect (1120,618) (1166,635) /dbget-bin/www_bget?hsa:329+hsa:330+hsa:331+H00107 329 (BIRC2), 330 (BIRC3), 331 (XIAP), H00107 (Other well-defined immunodeficiency syndromes, including the following seven diseases:) rect (869,660) (915,677) /dbget-bin/www_bget?hsa:572 572 (BAD) rect (931,660) (977,677) /dbget-bin/www_bget?hsa:596+H00005+H00013+H00018+H00028+H00030+H00041+H00054 596 (BCL2), H00005 (Chronic lymphocytic leukemia (CLL)), H00013 (Small cell lung cancer), H00018 (Gastric cancer), H00028 (Choriocarcinoma), H00030 (Cervical cancer), H00041 (Kaposi's sarcoma), H00054 (Nasopharyngeal cancer) rect (976,618) (1022,635) /dbget-bin/www_bget?hsa:2002 2002 (ELK1) rect (901,618) (947,635) /dbget-bin/www_bget?hsa:5594+hsa:5595 5594 (MAPK1), 5595 (MAPK3) rect (1120,429) (1166,446) /dbget-bin/www_bget?hsa:595+hsa:894+hsa:896+H00006+H00010+H00016+H00017+H00023+H00031+H00055 595 (CCND1), 894 (CCND2), 896 (CCND3), H00006 (Hairy-cell leukemia), H00010 (Multiple myeloma), H00016 (Oral cancer), H00017 (Esophageal cancer), H00023 (Testicular cancer), H00031 (Breast cancer), H00055 (Laryngeal cancer) rect (826,618) (872,635) /dbget-bin/www_bget?hsa:5604 5604 (MAP2K1) rect (792,569) (838,586) /dbget-bin/www_bget?hsa:673+H00032+H00038+D06272+D08524 673 (BRAF), H00032 (Thyroid cancer), H00038 (Malignant melanoma), D06272 (Sorafenib tosilate (JAN)), D08524 (Sorafenib (USAN/INN)) rect (619,618) (665,635) /dbget-bin/www_bget?hsa:5894 5894 (RAF1) rect (538,618) (584,635) /dbget-bin/www_bget?hsa:3265+H00022+H00025+H00030+H00032+H00040+H00048 3265 (HRAS), H00022 (Bladder cancer), H00025 (Penile cancer), H00030 (Cervical cancer), H00032 (Thyroid cancer), H00040 (Squamous cell carcinoma), H00048 (Hepatocellular carcinoma) rect (456,618) (502,635) /dbget-bin/www_bget?hsa:6654+hsa:6655 6654 (SOS1), 6655 (SOS2) rect (375,618) (421,635) /dbget-bin/www_bget?hsa:2885 2885 (GRB2) rect (169,618) (215,635) /dbget-bin/www_bget?hsa:1956+hsa:2064+hsa:2321+hsa:2324+hsa:3480+hsa:3791+hsa:4233+hsa:5156+hsa:5159+H00015+H00016+H00017+H00018+H00019+H00021+H00022+H00026+H00027+H00028+H00030+H00031+H00042+H00046+H00050+H00055+D01441+D01977+D03065+D03218+D03257+D03297+D03350+D03455+D03658+D04023+D04024+D04870+D05029+D05350+D05380+D05399+D05446+D05819+D06005+D06272+D06285+D06402+D06407+D06413+D06414+D06678+D07907+D08066+D08108+D08524+D08552+D08883+D08947+D08950+D08953+D09724+D09733 1956 (EGFR), 2064 (ERBB2), 2321 (FLT1), 2324 (FLT4), 3480 (IGF1R), 3791 (KDR), 4233 (MET), 5156 (PDGFRA), 5159 (PDGFRB), H00015 (Malignant pleural mesothelioma), H00016 (Oral cancer), H00017 (Esophageal cancer), H00018 (Gastric cancer), H00019 (Pancreatic cancer), H00021 (Renal cell carcinoma), H00022 (Bladder cancer), H00026 (Endometrial Cancer), H00027 (Ovarian cancer), H00028 (Choriocarcinoma), H00030 (Cervical cancer), H00031 (Breast cancer), H00042 (Glioma), H00046 (Cholangiocarcinoma), H00050 (Synovial sarcoma), H00055 (Laryngeal cancer), D01441 (Imatinib mesilate (JAN)), D01977 (Gefitinib (JAN/USAN/INN)), D03065 (Becaplermin (USAN/INN)), D03218 (Axitinib (JAN/USAN)), D03257 (Trastuzumab (genetical recombination) (JAN)), D03297 (Mecasermin (genetical recombination) (JAN)), D03350 (Canertinib dihydrochloride (USAN)), D03455 (Cetuximab (genetical recombination) (JAN)), D03658 (Dasatinib (INN)), D04023 (Erlotinib hydrochloride (JAN/USAN)), D04024 (Lapatinib tosilate hydrate (JAN)), D04870 (Mecasermin rinfabate (USAN/INN)), D05029 (Midostaurin (USAN/INN)), D05350 (Panitumumab (genetical recombination) (JAN)), D05380 (Pazopanib hydrochloride (JAN/USAN)), D05399 (Pelitinib (USAN/INN)), D05446 (Pertuzumab (genetical recombination) (JAN)), D05819 (Semaxanib (USAN/INN)), D06005 (Tandutinib (USAN/INN)), D06272 (Sorafenib tosilate (JAN)), D06285 (Vatalanib (USAN/INN)), D06402 (Sunitinib malate (JAN/USAN)), D06407 (Vandetanib (JAN/USAN/INN)), D06413 (Nilotinib hydrochloride hydrate (JAN)), D06414 (Dasatinib hydrate (JAN)), D06678 (Motesanib), D07907 (Erlotinib (INN)), D08066 (Imatinib (INN)), D08108 (Lapatinib (INN)), D08524 (Sorafenib (USAN/INN)), D08552 (Sunitinib (INN)), D08883 (Cediranib maleate (JAN/USAN)), D08947 (Motesanib diphosphate (USAN)), D08950 (Neratinib (INN/USAN)), D08953 (Nilotinib (INN/USAN)), D09724 (Afatinib (USAN/INN)), D09733 (Afatinib maleate (JAN)) rect (76,618) (122,635) /dbget-bin/www_bget?hsa:1950+hsa:2277+hsa:3082+hsa:3479+hsa:5154+hsa:5155+hsa:5228+hsa:56034+hsa:7422+hsa:7423+hsa:7424+hsa:80310+H00015+H00018+H00042+D06409 1950 (EGF), 2277 (FIGF), 3082 (HGF), 3479 (IGF1), 5154 (PDGFA), 5155 (PDGFB), 5228 (PGF), 56034 (PDGFC), 7422 (VEGFA), 7423 (VEGFB), 7424 (VEGFC), 80310 (PDGFD), H00015 (Malignant pleural mesothelioma), H00018 (Gastric cancer), H00042 (Glioma), D06409 (Bevacizumab (genetical recombination) (JAN)) rect (293,618) (339,635) /dbget-bin/www_bget?hsa:25759+hsa:399694+hsa:53358+hsa:6464 25759 (SHC2), 399694 (SHC4), 53358 (SHC3), 6464 (SHC1) rect (423,525) (469,542) /dbget-bin/www_bget?hsa:9564 9564 (BCAR1) rect (558,525) (604,542) /dbget-bin/www_bget?hsa:1398+hsa:1399 1398 (CRK), 1399 (CRKL) rect (647,525) (693,542) /dbget-bin/www_bget?hsa:2889 2889 (RAPGEF1) rect (766,525) (812,542) /dbget-bin/www_bget?hsa:5906+hsa:5908 5906 (RAP1A), 5908 (RAP1B) rect (675,484) (721,501) /dbget-bin/www_bget?hsa:1793 1793 (DOCK1) rect (888,525) (934,542) /dbget-bin/www_bget?hsa:5599+hsa:5601+hsa:5602 5599 (MAPK8), 5601 (MAPK9), 5602 (MAPK10) rect (976,525) (1022,542) /dbget-bin/www_bget?hsa:3725 3725 (JUN) rect (824,418) (870,435) /dbget-bin/www_bget?hsa:10298+hsa:5058+hsa:5062+hsa:5063+hsa:56924+hsa:57144 10298 (PAK4), 5058 (PAK1), 5062 (PAK2), 5063 (PAK3), 56924 (PAK6), 57144 (PAK7) rect (736,418) (782,435) /dbget-bin/www_bget?hsa:5879+hsa:5880+hsa:5881+H00099 5879 (RAC1), 5880 (RAC2), 5881 (RAC3), H00099 (Leukocyte adhesion deficiency (LAD), including the following four diseases:) rect (658,418) (704,435) /dbget-bin/www_bget?hsa:10451+hsa:7409+hsa:7410 10451 (VAV3), 7409 (VAV1), 7410 (VAV2) rect (976,319) (1022,336) /dbget-bin/www_bget?hsa:1499+H00018+H00020+H00026+H00032+H00048 1499 (CTNNB1), H00018 (Gastric cancer), H00020 (Colorectal cancer), H00026 (Endometrial Cancer), H00032 (Thyroid cancer), H00048 (Hepatocellular carcinoma) rect (875,318) (921,335) /dbget-bin/www_bget?hsa:2932 2932 (GSK3B) rect (908,241) (954,258) /dbget-bin/www_bget?hsa:60+hsa:71+H00101 60 (ACTB), 71 (ACTG1), H00101 (Other phagocyte defects, including the following eight diseases:) rect (51,290) (162,324) /kegg-bin/show_pathway?hsadd04512 hsadd04512: ECM-receptor interaction rect (51,547) (162,592) /kegg-bin/show_pathway?hsadd04060 hsadd04060: Cytokine-cytokine receptor interaction rect (560,453) (671,487) /kegg-bin/show_pathway?hsadd04070 hsadd04070: Phosphatidylinositol signaling system rect (878,563) (989,597) /kegg-bin/show_pathway?hsadd04010 hsadd04010: MAPK signaling pathway rect (40,45) (198,70) /dbget-bin/www_bget?hsa04510 hsadd04510: Focal adhesion rect (945,160) (1056,194) /kegg-bin/show_pathway?hsadd04810 hsadd04810: Regulation of actin cytoskeleton rect (909,415) (1002,440) /kegg-bin/show_pathway?hsadd04210 hsadd04210: Apoptosis rect (927,345) (1020,379) /kegg-bin/show_pathway?hsadd04310 hsadd04310: Wnt signaling pathway rect (1096,466) (1189,491) /kegg-bin/show_pathway?hsadd04110 hsadd04110: Cell cycle