circ (757,410) 4 /dbget-bin/www_bget?C05981 C05981 (Phosphatidylinositol-3,4,5-trisphosphate) circ (804,684) 4 /dbget-bin/www_bget?C00165 C00165 (Diacylglycerol) circ (851,649) 4 /dbget-bin/www_bget?C00076 C00076 (Calcium cation) circ (805,649) 4 /dbget-bin/www_bget?C01245 C01245 (D-myo-Inositol 1,4,5-trisphosphate) rect (964,640) (1010,657) /dbget-bin/www_bget?hsa:10725+hsa:4772+hsa:4773+hsa:4775+hsa:4776 10725 (NFAT5), 4772 (NFATC1), 4773 (NFATC2), 4775 (NFATC3), 4776 (NFATC4) rect (889,640) (935,657) /dbget-bin/www_bget?hsa:11261+hsa:5530+hsa:5532+hsa:5533+hsa:5534+hsa:5535+hsa:63928 11261 (CHP), 5530 (PPP3CA), 5532 (PPP3CB), 5533 (PPP3CC), 5534 (PPP3R1), 5535 (PPP3R2), 63928 (CHP2) rect (615,722) (661,739) /dbget-bin/www_bget?hsa:2534 2534 (FYN) rect (1154,802) (1200,819) /dbget-bin/www_bget?hsa:8743 8743 (TNFSF10) rect (264,748) (310,765) /dbget-bin/www_bget?hsa:3459+hsa:3460+H00089+H00342+D00747+D03357+D08805 3459 (IFNGR1), 3460 (IFNGR2), H00089 (IFN-gamma/IL-12 axis, including the following five diseases:), H00342 (Tuberculosis), D00747 (Interferon gamma-1b (USAN/INN)), D03357 (Interferon gamma-1a (genetical recombination) (JAN)), D08805 (Interferon gamma-n1 (JAN)) rect (716,641) (762,658) /dbget-bin/www_bget?hsa:5335+hsa:5336 5335 (PLCG1), 5336 (PLCG2) rect (642,640) (688,657) /dbget-bin/www_bget?hsa:27040 27040 (LAT) rect (264,937) (310,954) /dbget-bin/www_bget?hsa:5551+H00109 5551 (PRF1), H00109 (Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases:) rect (264,289) (310,306) /dbget-bin/www_bget?hsa:3133 3133 (HLA-E) rect (1159,664) (1205,681) /dbget-bin/www_bget?hsa:3458+H00083+H00084 3458 (IFNG), H00083 (Allograft rejection), H00084 (Graft-versus-host disease) rect (1159,640) (1205,657) /dbget-bin/www_bget?hsa:1437 1437 (CSF2) rect (1159,616) (1205,633) /dbget-bin/www_bget?hsa:7124+H00079+H00080+H00083+H00084+D02597+D02598+D03441+D04358+D04687+D09813 7124 (TNF), H00079 (Asthma), H00080 (Systemic lupus erythematosus), H00083 (Allograft rejection), H00084 (Graft-versus-host disease), D02597 (Adalimumab (genetical recombination) (JAN)), D02598 (Infliximab (genetical recombination) (JAN)), D03441 (Certolizumab pegol (genetical recombination) (JAN)), D04358 (Golimumab (genetical recombination) (JAN)), D04687 (Lenalidomide (USAN/INN)), D09813 (Lenalidomide hydrate (JAN)) rect (874,675) (920,692) /dbget-bin/www_bget?hsa:5578+hsa:5579+hsa:5582+H00063+D01066+D02970+D08401 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG), H00063 (Spinocerebellar ataxia (SCA)), D01066 (Polymixin B sulfate (JP16)), D02970 (Aprinocarsen sodium (USAN)), D08401 (Polymyxin B (INN)) rect (645,374) (691,391) /dbget-bin/www_bget?hsa:6452 6452 (SH3BP2) rect (698,442) (744,459) /dbget-bin/www_bget?hsa:5335+hsa:5336 5335 (PLCG1), 5336 (PLCG2) rect (640,457) (686,474) /dbget-bin/www_bget?hsa:27040 27040 (LAT) rect (657,241) (703,258) /dbget-bin/www_bget?hsa:2185 2185 (PTK2B) rect (640,436) (686,453) /dbget-bin/www_bget?hsa:3937 3937 (LCP2) rect (552,497) (598,514) /dbget-bin/www_bget?hsa:6850 6850 (SYK) rect (552,475) (598,492) /dbget-bin/www_bget?hsa:7535+H00093 7535 (ZAP70), H00093 (Combined immunodeficiencies (CIDs), including the following nine diseases:) rect (562,401) (608,418) /dbget-bin/www_bget?hsa:3932+H00093 3932 (LCK), H00093 (Combined immunodeficiencies (CIDs), including the following nine diseases:) rect (585,672) (631,689) /dbget-bin/www_bget?hsa:117157 117157 (SH2D1B) rect (551,531) (597,548) /dbget-bin/www_bget?hsa:2534 2534 (FYN) rect (530,695) (576,712) /dbget-bin/www_bget?hsa:4068+H00107 4068 (SH2D1A), H00107 (Other well-defined immunodeficiency syndromes, including the following seven diseases:) rect (479,629) (525,646) /dbget-bin/www_bget?hsa:10870 10870 (HCST) rect (477,562) (523,579) /dbget-bin/www_bget?hsa:919 919 (CD247) rect (477,539) (523,556) /dbget-bin/www_bget?hsa:2207+D05251 2207 (FCER1G), D05251 (Omalizumab (genetical recombination) (JAN)) rect (477,421) (523,438) /dbget-bin/www_bget?hsa:7305 7305 (TYROBP) rect (501,229) (547,246) /dbget-bin/www_bget?hsa:5781 5781 (PTPN11) rect (501,204) (547,221) /dbget-bin/www_bget?hsa:5777 5777 (PTPN6) rect (339,802) (385,819) /dbget-bin/www_bget?hsa:3439+hsa:3440+hsa:3441+hsa:3442+hsa:3443+hsa:3444+hsa:3445+hsa:3446+hsa:3447+hsa:3448+hsa:3449+hsa:3451+hsa:3452+hsa:3456+hsa:3458+H00083+H00084 3439 (IFNA1), 3440 (IFNA2), 3441 (IFNA4), 3442 (IFNA5), 3443 (IFNA6), 3444 (IFNA7), 3445 (IFNA8), 3446 (IFNA10), 3447 (IFNA13), 3448 (IFNA14), 3449 (IFNA16), 3451 (IFNA17), 3452 (IFNA21), 3456 (IFNB1), 3458 (IFNG), H00083 (Allograft rejection), H00084 (Graft-versus-host disease) rect (46,939) (92,956) /dbget-bin/www_bget?hsa:637 637 (BID) rect (46,894) (92,911) /dbget-bin/www_bget?hsa:836 836 (CASP3) rect (149,916) (195,933) /dbget-bin/www_bget?hsa:3002 3002 (GZMB) rect (264,897) (310,914) /dbget-bin/www_bget?hsa:5551+H00109 5551 (PRF1), H00109 (Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases:) rect (264,855) (310,872) /dbget-bin/www_bget?hsa:355+H00005+H00007+H00009+H00017 355 (FAS), H00005 (Chronic lymphocytic leukemia (CLL)), H00007 (Hodgkin lymphoma), H00009 (Adult T-cell leukemia), H00017 (Esophageal cancer) rect (264,829) (310,846) /dbget-bin/www_bget?hsa:8793+hsa:8794+hsa:8795+hsa:8797 8793 (TNFRSF10D), 8794 (TNFRSF10C), 8795 (TNFRSF10B), 8797 (TNFRSF10A) rect (264,694) (310,711) /dbget-bin/www_bget?hsa:962 962 (CD48) rect (264,651) (310,668) /dbget-bin/www_bget?hsa:79465+hsa:80328+hsa:80329 79465 (ULBP3), 80328 (ULBP2), 80329 (ULBP1) rect (264,628) (310,645) /dbget-bin/www_bget?hsa:4277 4277 (MICB) rect (264,606) (310,623) /dbget-bin/www_bget?hsa:100507436 100507436 (MICA) rect (264,329) (310,346) /dbget-bin/www_bget?hsa:3383+hsa:3384+H00083+D02811 3383 (ICAM1), 3384 (ICAM2), H00083 (Allograft rejection), D02811 (Alicaforsen sodium (USAN)) rect (264,264) (310,281) /dbget-bin/www_bget?hsa:3107 3107 (HLA-C) rect (264,216) (310,233) /dbget-bin/www_bget?hsa:3106 3106 (HLA-B) rect (264,190) (310,207) /dbget-bin/www_bget?hsa:3135 3135 (HLA-G) rect (264,165) (310,182) /dbget-bin/www_bget?hsa:3105 3105 (HLA-A) rect (757,485) (803,502) /dbget-bin/www_bget?hsa:23533+hsa:5290+hsa:5291+hsa:5293+hsa:5294+hsa:5295+hsa:5296+hsa:8503+H00027 23533 (PIK3R5), 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5294 (PIK3CG), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3), H00027 (Ovarian cancer) rect (264,140) (310,157) /dbget-bin/www_bget?hsa:3106 3106 (HLA-B) rect (1000,608) (1046,625) /dbget-bin/www_bget?hsa:5594+hsa:5595 5594 (MAPK1), 5595 (MAPK3) rect (916,531) (962,548) /dbget-bin/www_bget?hsa:5604+hsa:5605 5604 (MAP2K1), 5605 (MAP2K2) rect (918,577) (964,594) /dbget-bin/www_bget?hsa:369+hsa:5894+hsa:673+H00032+H00038+D06272+D08524 369 (ARAF), 5894 (RAF1), 673 (BRAF), H00032 (Thyroid cancer), H00038 (Malignant melanoma), D06272 (Sorafenib tosilate (JAN)), D08524 (Sorafenib (USAN/INN)) rect (848,577) (894,594) /dbget-bin/www_bget?hsa:3265+hsa:3845+hsa:4893+H00003+H00010+H00014+H00016+H00018+H00019+H00020+H00022+H00025+H00026+H00027+H00030+H00032+H00033+H00038+H00040+H00041+H00046+H00047+H00048+H00108 3265 (HRAS), 3845 (KRAS), 4893 (NRAS), H00003 (Acute myeloid leukemia (AML)), H00010 (Multiple myeloma), H00014 (Non-small cell lung cancer), H00016 (Oral cancer), H00018 (Gastric cancer), H00019 (Pancreatic cancer), H00020 (Colorectal cancer), H00022 (Bladder cancer), H00025 (Penile cancer), H00026 (Endometrial Cancer), H00027 (Ovarian cancer), H00030 (Cervical cancer), H00032 (Thyroid cancer), H00033 (Adrenal carcinoma), H00038 (Malignant melanoma), H00040 (Squamous cell carcinoma), H00041 (Kaposi's sarcoma), H00046 (Cholangiocarcinoma), H00047 (Gallbladder cancer), H00048 (Hepatocellular carcinoma), H00108 (Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases:) rect (779,577) (825,594) /dbget-bin/www_bget?hsa:6654+hsa:6655 6654 (SOS1), 6655 (SOS2) rect (707,577) (753,594) /dbget-bin/www_bget?hsa:2885 2885 (GRB2) rect (635,577) (681,594) /dbget-bin/www_bget?hsa:25759+hsa:399694+hsa:53358+hsa:6464 25759 (SHC2), 399694 (SHC4), 53358 (SHC3), 6464 (SHC1) rect (825,483) (871,500) /dbget-bin/www_bget?hsa:5058 5058 (PAK1) rect (774,331) (820,348) /dbget-bin/www_bget?hsa:5879+hsa:5880+hsa:5881+H00099 5879 (RAC1), 5880 (RAC2), 5881 (RAC3), H00099 (Leukocyte adhesion deficiency (LAD), including the following four diseases:) rect (701,330) (747,347) /dbget-bin/www_bget?hsa:10451+hsa:7409+hsa:7410 10451 (VAV3), 7409 (VAV1), 7410 (VAV2) rect (478,901) (524,918) /dbget-bin/www_bget?hsa:356+H00108 356 (FASLG), H00108 (Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases:) rect (531,917) (577,934) /dbget-bin/www_bget?hsa:3002 3002 (GZMB) rect (478,937) (524,954) /dbget-bin/www_bget?hsa:5551+H00109 5551 (PRF1), H00109 (Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases:) rect (406,430) (452,447) /dbget-bin/www_bget?hsa:3824 3824 (KLRD1) rect (406,855) (452,872) /dbget-bin/www_bget?hsa:356+H00108 356 (FASLG), H00108 (Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases:) rect (406,829) (452,846) /dbget-bin/www_bget?hsa:8743 8743 (TNFSF10) rect (406,802) (452,819) /dbget-bin/www_bget?hsa:3454+hsa:3455+hsa:3459+hsa:3460+H00089+H00342+D00745+D00746+D00747+D02744+D02745+D02747+D02748+D03304+D03305+D03357+D04552+D04554+D08805+D08844 3454 (IFNAR1), 3455 (IFNAR2), 3459 (IFNGR1), 3460 (IFNGR2), H00089 (IFN-gamma/IL-12 axis, including the following five diseases:), H00342 (Tuberculosis), D00745 (Interferon alfa-2a (genetical recombination) (JAN)), D00746 (Interferon beta-1b (genetical recombination) (JAN)), D00747 (Interferon gamma-1b (USAN/INN)), D02744 (Interferon alfacon-1 (genetical recombination) (JAN)), D02745 (Interferon alfa-2b (genetical recombination) (JAN)), D02747 (Peginterferon alfa-2a (genetical recombination) (JAN)), D02748 (Peginterferon alfa-2b (generical recombination) (JAN)), D03304 (Interferon beta (JAN)), D03305 (Interferon alfa (BALL-1) (JAN)), D03357 (Interferon gamma-1a (genetical recombination) (JAN)), D04552 (Interferon alfa-n1 (USAN)), D04554 (Interferon beta-1a (genetical recombination) (JAN)), D08805 (Interferon gamma-n1 (JAN)), D08844 (Albinterferon alfa-2b (USAN)) rect (406,694) (452,711) /dbget-bin/www_bget?hsa:51744 51744 (CD244) rect (406,628) (452,645) /dbget-bin/www_bget?hsa:22914 22914 (KLRK1) rect (406,578) (452,595) /dbget-bin/www_bget?hsa:259197 259197 (NCR3) rect (406,519) (452,536) /dbget-bin/www_bget?hsa:9437 9437 (NCR1) rect (406,550) (452,567) /dbget-bin/www_bget?hsa:2214+hsa:2215+H00080+H00090 2214 (FCGR3A), 2215 (FCGR3B), H00080 (Systemic lupus erythematosus), H00090 (NK cell defects, including the following disease:) rect (406,464) (452,481) /dbget-bin/www_bget?hsa:9436 9436 (NCR2) rect (406,413) (452,430) /dbget-bin/www_bget?hsa:3822+hsa:3823 3822 (KLRC2), 3823 (KLRC3) rect (406,378) (452,395) /dbget-bin/www_bget?hsa:3806+hsa:3808+hsa:3809+hsa:3810 3806 (KIR2DS1), 3808 (KIR2DS3), 3809 (KIR2DS4), 3810 (KIR2DS5) rect (406,337) (452,354) /dbget-bin/www_bget?hsa:3689+H00099 3689 (ITGB2), H00099 (Leukocyte adhesion deficiency (LAD), including the following four diseases:) rect (406,320) (452,337) /dbget-bin/www_bget?hsa:3683+D03959 3683 (ITGAL), D03959 (Efalizumab (USAN/INN)) rect (406,262) (452,279) /dbget-bin/www_bget?hsa:3824 3824 (KLRD1) rect (406,245) (452,262) /dbget-bin/www_bget?hsa:3821 3821 (KLRC1) rect (406,211) (452,228) /dbget-bin/www_bget?hsa:3802+hsa:3803+hsa:3804+hsa:3805+hsa:57292 3802 (KIR2DL1), 3803 (KIR2DL2), 3804 (KIR2DL3), 3805 (KIR2DL4), 57292 (KIR2DL5A) rect (406,169) (452,186) /dbget-bin/www_bget?hsa:3812 3812 (KIR3DL2) rect (406,139) (452,156) /dbget-bin/www_bget?hsa:3811 3811 (KIR3DL1) rect (1034,263) (1080,280) /dbget-bin/www_bget?hsa:3383+hsa:3384+H00083+D02811 3383 (ICAM1), 3384 (ICAM2), H00083 (Allograft rejection), D02811 (Alicaforsen sodium (USAN)) rect (1034,502) (1080,519) /dbget-bin/www_bget?hsa:135250+hsa:154064+hsa:353091 135250 (RAET1E), 154064 (RAET1L), 353091 (RAET1G) rect (1177,211) (1223,228) /dbget-bin/www_bget?hsa:3824 3824 (KLRD1) rect (1177,254) (1223,271) /dbget-bin/www_bget?hsa:3683+D03959 3683 (ITGAL), D03959 (Efalizumab (USAN/INN)) rect (1177,271) (1223,288) /dbget-bin/www_bget?hsa:3689+H00099 3689 (ITGB2), H00099 (Leukocyte adhesion deficiency (LAD), including the following four diseases:) rect (1177,344) (1223,361) /dbget-bin/www_bget?hsa:3824 3824 (KLRD1) rect (1177,405) (1223,422) /dbget-bin/www_bget?hsa:2214+hsa:2215+H00080+H00090 2214 (FCGR3A), 2215 (FCGR3B), H00080 (Systemic lupus erythematosus), H00090 (NK cell defects, including the following disease:) rect (1177,431) (1223,448) /dbget-bin/www_bget?hsa:9437 9437 (NCR1) rect (1177,502) (1223,519) /dbget-bin/www_bget?hsa:22914 22914 (KLRK1) rect (40,45) (419,70) /dbget-bin/www_bget?hsa04650 hsadd04650: Natural killer cell mediated cytotoxicity rect (765,529) (878,563) /kegg-bin/show_pathway?hsadd04010 hsadd04010: MAPK signaling pathway rect (914,705) (1014,739) /kegg-bin/show_pathway?hsadd04020 hsadd04020: Calcium signaling pathway rect (647,795) (756,829) /kegg-bin/show_pathway?hsadd04630 hsadd04630: Jak-STAT signaling pathway rect (479,767) (588,802) /kegg-bin/show_pathway?hsadd04060 hsadd04060: Cytokine-cytokine receptor interaction rect (41,508) (150,533) /kegg-bin/show_pathway?hsadd04210 hsadd04210: Apoptosis