circ (589,830) 4 /dbget-bin/www_bget?C06314 C06314 (Lipoxin A4) circ (530,702) 4 /dbget-bin/www_bget?C05981 C05981 (Phosphatidylinositol-3,4,5-trisphosphate) circ (75,460) 4 /dbget-bin/www_bget?C00076 C00076 (Calcium cation) rect (379,323) (425,340) /dbget-bin/www_bget?hsa:4615 4615 (MYD88) rect (456,323) (502,340) /dbget-bin/www_bget?hsa:3654+hsa:51135+H00096 3654 (IRAK1), 51135 (IRAK4), H00096 (Defects of toll-like receptor signaling, including the following disease:) rect (533,323) (579,340) /dbget-bin/www_bget?hsa:7189 7189 (TRAF6) rect (610,323) (656,340) /dbget-bin/www_bget?hsa:6885 6885 (MAP3K7) rect (610,340) (656,357) /dbget-bin/www_bget?hsa:10454+hsa:23118 10454 (TAB1), 23118 (TAB2) rect (816,323) (862,340) /dbget-bin/www_bget?hsa:1147+hsa:3551+hsa:8517+H00095 1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG), H00095 (Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases:) rect (906,323) (952,340) /dbget-bin/www_bget?hsa:4792+hsa:4793+H00007+H00095 4792 (NFKBIA), 4793 (NFKBIB), H00007 (Hodgkin lymphoma), H00095 (Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases:) rect (906,363) (952,380) /dbget-bin/www_bget?hsa:4790+hsa:5970 4790 (NFKB1), 5970 (RELA) rect (779,214) (825,231) /dbget-bin/www_bget?hsa:5594+hsa:5595 5594 (MAPK1), 5595 (MAPK3) rect (779,246) (825,263) /dbget-bin/www_bget?hsa:5599+hsa:5601+hsa:5602 5599 (MAPK8), 5601 (MAPK9), 5602 (MAPK10) rect (779,278) (825,295) /dbget-bin/www_bget?hsa:1432+hsa:5600+hsa:5603+hsa:6300+D03736 1432 (MAPK14), 5600 (MAPK11), 5603 (MAPK13), 6300 (MAPK12), D03736 (Doramapimod (USAN/INN)) rect (699,278) (745,295) /dbget-bin/www_bget?hsa:5606+hsa:5608 5606 (MAP2K3), 5608 (MAP2K6) rect (375,758) (421,775) /dbget-bin/www_bget?hsa:2770+hsa:2771+hsa:2773+hsa:2775+H00033 2770 (GNAI1), 2771 (GNAI2), 2773 (GNAI3), 2775 (GNAO1), H00033 (Adrenal carcinoma) rect (1144,353) (1190,370) /dbget-bin/www_bget?hsa:3592+hsa:3593+H00089 3592 (IL12A), 3593 (IL12B), H00089 (IFN-gamma/IL-12 axis, including the following five diseases:) rect (1144,373) (1190,390) /dbget-bin/www_bget?hsa:7124+H00079+H00080+H00083+H00084+D02597+D02598+D03441+D04358+D04687+D09813 7124 (TNF), H00079 (Asthma), H00080 (Systemic lupus erythematosus), H00083 (Allograft rejection), H00084 (Graft-versus-host disease), D02597 (Adalimumab (genetical recombination) (JAN)), D02598 (Infliximab (genetical recombination) (JAN)), D03441 (Certolizumab pegol (genetical recombination) (JAN)), D04358 (Golimumab (genetical recombination) (JAN)), D04687 (Lenalidomide (USAN/INN)), D09813 (Lenalidomide hydrate (JAN)) rect (1144,451) (1190,468) /dbget-bin/www_bget?hsa:596+hsa:598+H00005+H00013+H00018+H00028+H00030+H00041+H00054 596 (BCL2), 598 (BCL2L1), H00005 (Chronic lymphocytic leukemia (CLL)), H00013 (Small cell lung cancer), H00018 (Gastric cancer), H00028 (Choriocarcinoma), H00030 (Cervical cancer), H00041 (Kaposi's sarcoma), H00054 (Nasopharyngeal cancer) rect (1144,471) (1190,488) /dbget-bin/www_bget?hsa:329+hsa:330+hsa:331+H00107 329 (BIRC2), 330 (BIRC3), 331 (XIAP), H00107 (Other well-defined immunodeficiency syndromes, including the following seven diseases:) rect (1144,237) (1190,254) /dbget-bin/www_bget?hsa:4843+H00017 4843 (NOS2), H00017 (Esophageal cancer) rect (1144,747) (1190,764) /dbget-bin/www_bget?hsa:3592+hsa:3593+H00089 3592 (IL12A), 3593 (IL12B), H00089 (IFN-gamma/IL-12 axis, including the following five diseases:) rect (342,169) (388,186) /dbget-bin/www_bget?hsa:3716+hsa:3717+H00012+D09783 3716 (JAK1), 3717 (JAK2), H00012 (Polycythemia vera), D09783 (Tofacitinib citrate (JAN)) rect (601,169) (647,186) /dbget-bin/www_bget?hsa:6772+H00089 6772 (STAT1), H00089 (IFN-gamma/IL-12 axis, including the following five diseases:) rect (779,127) (825,144) /dbget-bin/www_bget?hsa:4261+H00093 4261 (CIITA), H00093 (Combined immunodeficiencies (CIDs), including the following nine diseases:) rect (1144,171) (1190,188) /dbget-bin/www_bget?hsa:345611 345611 (IRGM) rect (1144,126) (1190,143) /dbget-bin/www_bget?hsa:100133583+hsa:3108+hsa:3109+hsa:3111+hsa:3112+hsa:3113+hsa:3115+hsa:3117+hsa:3118+hsa:3119+hsa:3122+hsa:3123+hsa:3125+hsa:3126+hsa:3127+H00079+H00080+H00081+H00082+H00083+H00294+H00295+H00342+H00408 100133583, 3108 (HLA-DMA), 3109 (HLA-DMB), 3111 (HLA-DOA), 3112 (HLA-DOB), 3113 (HLA-DPA1), 3115 (HLA-DPB1), 3117 (HLA-DQA1), 3118 (HLA-DQA2), 3119 (HLA-DQB1), 3122 (HLA-DRA), 3123 (HLA-DRB1), 3125 (HLA-DRB3), 3126 (HLA-DRB4), 3127 (HLA-DRB5), H00079 (Asthma), H00080 (Systemic lupus erythematosus), H00081 (Hashimoto's thyroiditis), H00082 (Graves' disease), H00083 (Allograft rejection), H00294 (Dilated cardiomyopathy (DCM)), H00295 (Viral myocarditis), H00342 (Tuberculosis), H00408 (Type I diabetes mellitus) rect (465,822) (511,839) /dbget-bin/www_bget?hsa:240+D00414+D01773+D03010+D03080+D03652+D03882+D03990+D04151+D04770 240 (ALOX5), D00414 (Zileuton (USP/INN)), D01773 (Oxatomide (JAN/USAN/INN)), D03010 (Atreleuton (USAN/INN)), D03080 (Benoxaprofen (USAN/INN)), D03652 (Darbufelone mesylate (USAN)), D03882 (Docebenone (USAN/INN)), D03990 (Enazadrem phosphate (USAN)), D04151 (Fenleuton (USAN/INN)), D04770 (Lonapalene (USAN)) rect (394,217) (440,234) /dbget-bin/www_bget?hsa:8651 8651 (SOCS1) rect (624,622) (670,639) /dbget-bin/www_bget?hsa:54205 54205 (CYCS) rect (602,922) (648,939) /dbget-bin/www_bget?hsa:6774+H00016+H00107 6774 (STAT3), H00016 (Oral cancer), H00107 (Other well-defined immunodeficiency syndromes, including the following seven diseases:) rect (707,622) (753,639) /dbget-bin/www_bget?hsa:842 842 (CASP9) rect (790,622) (836,639) /dbget-bin/www_bget?hsa:836 836 (CASP3) rect (707,650) (753,667) /dbget-bin/www_bget?hsa:841+H00108 841 (CASP8), H00108 (Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases:) rect (375,693) (421,710) /dbget-bin/www_bget?hsa:2770+hsa:2771+hsa:2773+hsa:2775+H00033 2770 (GNAI1), 2771 (GNAI2), 2773 (GNAI3), 2775 (GNAO1), H00033 (Adrenal carcinoma) rect (455,693) (501,710) /dbget-bin/www_bget?hsa:23533+hsa:5290+hsa:5291+hsa:5293+hsa:5294+hsa:5295+hsa:5296+hsa:8503+H00027 23533 (PIK3R5), 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5294 (PIK3CG), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3), H00027 (Ovarian cancer) rect (559,693) (605,710) /dbget-bin/www_bget?hsa:5163 5163 (PDK1) rect (639,693) (685,710) /dbget-bin/www_bget?hsa:10000+hsa:207+hsa:208+H00027+H00420 10000 (AKT3), 207 (AKT1), 208 (AKT2), H00027 (Ovarian cancer), H00420 (Familial partial lipodystrophy (FPL), including the following four diseases:) rect (303,372) (349,389) /dbget-bin/www_bget?hsa:3655+hsa:3688 3655 (ITGA6), 3688 (ITGB1) rect (111,462) (157,479) /dbget-bin/www_bget?hsa:100137049+hsa:123745+hsa:26279+hsa:30814+hsa:391013+hsa:50487+hsa:5319+hsa:5320+hsa:5321+hsa:5322+hsa:64600+hsa:81579+hsa:8398+hsa:8399+hsa:84647+hsa:8681+H00057+D02548+D03650+D03938+D06283+D08179 100137049 (PLA2G4B), 123745 (PLA2G4E), 26279 (PLA2G2D), 30814 (PLA2G2E), 391013 (PLA2G2C), 50487 (PLA2G3), 5319 (PLA2G1B), 5320 (PLA2G2A), 5321 (PLA2G4A), 5322 (PLA2G5), 64600 (PLA2G2F), 81579 (PLA2G12A), 8398 (PLA2G6), 8399 (PLA2G10), 84647 (PLA2G12B), 8681 (JMJD7-PLA2G4B), H00057 (Parkinson's disease (PD)), D02548 (Mepacrine dihydrochloride), D03650 (Darapladib (USAN)), D03938 (Ecopladib (USAN/INN)), D06283 (Varespladib sodium (USAN)), D08179 (Mepacrine (INN)) rect (165,405) (211,422) /dbget-bin/www_bget?hsa:10319+hsa:22798+hsa:284217+hsa:3908+hsa:3909+hsa:3910+hsa:3911+hsa:3912+hsa:3913+hsa:3914+hsa:3915+hsa:3918 10319 (LAMC3), 22798 (LAMB4), 284217 (LAMA1), 3908 (LAMA2), 3909 (LAMA3), 3910 (LAMA4), 3911 (LAMA5), 3912 (LAMB1), 3913 (LAMB2), 3914 (LAMB3), 3915 (LAMC1), 3918 (LAMC2) rect (257,281) (303,298) /dbget-bin/www_bget?hsa:23643 23643 (LY96) rect (303,293) (349,310) /dbget-bin/www_bget?hsa:7099+D04043+D09573 7099 (TLR4), D04043 (Eritoran tetrasodium (USAN)), D09573 (Eritoran sodium (JAN)) rect (241,342) (287,359) /dbget-bin/www_bget?hsa:3303+hsa:3304+hsa:3305+hsa:3306+hsa:3310+hsa:3312 3303 (HSPA1A), 3304 (HSPA1B), 3305 (HSPA1L), 3306 (HSPA2), 3310 (HSPA6), 3312 (HSPA8) rect (303,323) (349,340) /dbget-bin/www_bget?hsa:7097 7097 (TLR2) rect (240,152) (286,169) /dbget-bin/www_bget?hsa:3458+H00083+H00084 3458 (IFNG), H00083 (Allograft rejection), H00084 (Graft-versus-host disease) rect (303,152) (349,169) /dbget-bin/www_bget?hsa:3459+hsa:3460+H00089+H00342+D00747+D03357+D08805 3459 (IFNGR1), 3460 (IFNGR2), H00089 (IFN-gamma/IL-12 axis, including the following five diseases:), H00342 (Tuberculosis), D00747 (Interferon gamma-1b (USAN/INN)), D03357 (Interferon gamma-1a (genetical recombination) (JAN)), D08805 (Interferon gamma-n1 (JAN)) rect (303,758) (349,775) /dbget-bin/www_bget?hsa:1234+D03210+D06297+D06557+D06670 1234 (CCR5), D03210 (Ancriviroc (USAN/INN)), D06297 (Vicriviroc maleate (USAN)), D06557 (Aplaviroc hydrochloride (USAN)), D06670 (Maraviroc (JAN/INN)) rect (241,758) (287,775) /dbget-bin/www_bget?hsa:10105 10105 (PPIF) rect (241,735) (287,752) /dbget-bin/www_bget?hsa:959+H00093 959 (CD40LG), H00093 (Combined immunodeficiencies (CIDs), including the following nine diseases:) rect (303,735) (349,752) /dbget-bin/www_bget?hsa:958+H00093 958 (CD40), H00093 (Combined immunodeficiencies (CIDs), including the following nine diseases:) rect (740,693) (786,710) /dbget-bin/www_bget?hsa:572 572 (BAD) rect (241,650) (287,667) /dbget-bin/www_bget?hsa:7124+H00079+H00080+H00083+H00084+D02597+D02598+D03441+D04358+D04687+D09813 7124 (TNF), H00079 (Asthma), H00080 (Systemic lupus erythematosus), H00083 (Allograft rejection), H00084 (Graft-versus-host disease), D02597 (Adalimumab (genetical recombination) (JAN)), D02598 (Infliximab (genetical recombination) (JAN)), D03441 (Certolizumab pegol (genetical recombination) (JAN)), D04358 (Golimumab (genetical recombination) (JAN)), D04687 (Lenalidomide (USAN/INN)), D09813 (Lenalidomide hydrate (JAN)) rect (303,650) (349,667) /dbget-bin/www_bget?hsa:7132+D00742 7132 (TNFRSF1A), D00742 (Etanercept (genetical recombination) (JAN)) rect (676,586) (722,603) /dbget-bin/www_bget?hsa:596+hsa:598+H00005+H00013+H00018+H00028+H00030+H00041+H00054 596 (BCL2), 598 (BCL2L1), H00005 (Chronic lymphocytic leukemia (CLL)), H00013 (Small cell lung cancer), H00018 (Gastric cancer), H00028 (Choriocarcinoma), H00030 (Cervical cancer), H00041 (Kaposi's sarcoma), H00054 (Nasopharyngeal cancer) rect (748,586) (794,603) /dbget-bin/www_bget?hsa:329+hsa:330+hsa:331+H00107 329 (BIRC2), 330 (BIRC3), 331 (XIAP), H00107 (Other well-defined immunodeficiency syndromes, including the following seven diseases:) rect (303,556) (349,573) /dbget-bin/www_bget?hsa:3949+H00155 3949 (LDLR), H00155 (Hypercholesterolemia, autosomal dominant) rect (1144,996) (1190,1013) /dbget-bin/www_bget?hsa:3586+H00083+H00084 3586 (IL10), H00083 (Allograft rejection), H00084 (Graft-versus-host disease) rect (1144,1017) (1190,1034) /dbget-bin/www_bget?hsa:7040+hsa:7042+hsa:7043+H00083+H00084+H00293 7040 (TGFB1), 7042 (TGFB2), 7043 (TGFB3), H00083 (Allograft rejection), H00084 (Graft-versus-host disease), H00293 (Arrhythmogenic right ventricular cardiomyopathy (ARVC)) rect (303,904) (349,921) /dbget-bin/www_bget?hsa:3587+hsa:3588 3587 (IL10RA), 3588 (IL10RB) rect (241,904) (287,921) /dbget-bin/www_bget?hsa:3586+H00083+H00084 3586 (IL10), H00083 (Allograft rejection), H00084 (Graft-versus-host disease) rect (342,921) (388,938) /dbget-bin/www_bget?hsa:3716+hsa:7297+H00107+D09783 3716 (JAK1), 7297 (TYK2), H00107 (Other well-defined immunodeficiency syndromes, including the following seven diseases:), D09783 (Tofacitinib citrate (JAN)) rect (851,619) (943,644) /kegg-bin/show_pathway?hsadd04210 hsadd04210: Apoptosis rect (410,148) (563,173) /kegg-bin/show_pathway?hsadd04630 hsadd04630: Jak-STAT signaling pathway rect (873,219) (1011,244) /kegg-bin/show_pathway?hsadd04010 hsadd04010: MAPK signaling pathway rect (442,282) (538,316) /kegg-bin/show_pathway?hsadd04620 hsadd04620: Toll-like receptor signaling pathway rect (426,843) (580,868) /kegg-bin/show_pathway?hsadd00590 hsadd00590: Arachidonic acid metabolism rect (367,588) (441,613) /kegg-bin/show_pathway?hsadd04144 hsadd04144: Endocytosis rect (410,933) (563,958) /kegg-bin/show_pathway?hsadd04630 hsadd04630: Jak-STAT signaling pathway rect (40,45) (190,70) /dbget-bin/www_bget?hsa05145 hsadd05145: Toxoplasmosis